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RUVBL1 RuvB-like 1 (E. coli) [ Homo sapiens (human) ]

Gene ID: 8607, updated on 9-Jun-2013

Summary

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Official Symbol: RUVBL1provided by HGNC
Official Full Name: RuvB-like 1 (E. coli)provided by HGNC
Primary source: HGNC:10474
See related: Ensembl:ENSG00000175792; HPRD:09143; MIM:603449; Vega:OTTHUMG00000159658
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RVB1; TIH1; ECP54; TIP49; INO80H; NMP238; PONTIN; TIP49A; Pontin52

Genomic context

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Location :: 3q21

Sequence :: Chromosome: 3; NC_000003.11 (127799800..127842671, complement)

See RUVBL1 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pontin-positivity seems to be a negative predictor for response to adjuvant therapy in colorectal cancer patients and may help to identify patients with adverse outcome in advanced tumor stages.
Title: Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma.
Two coexisting conformations, compact and stretched, are revealed by analysis of cryo-electron microscopy structures of the RuvBL1-RuvBL2 complex.
Title: Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1-RuvBL2 complex.
First insight into the mechanism of action of pontin and reptin in the assembly of macromolecular complexes.
Title: Mechanism of the AAA+ ATPases pontin and reptin in the biogenesis of H/ACA RNPs.
DNA unwinding of the human RuvBL proteins can be auto-inhibited by domain II, which is not present in the homologous bacterial helicase RuvB.
Title: Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex.
Pontin is methylated by G9a/GLP methyltransferases in hypoxic condition and potentiates HIF-1alpha-mediated activation by increasing the recruitment of p300 coactivator to a subset of HIF-1alpha target promoters.
Title: Hypoxia-induced methylation of a pontin chromatin remodeling factor.
These results indicate that EHF-mediated RUVBL1 expression allows colon tumour cells to avoid p53-mediated apoptosis.
Title: A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis.
S100A9 and NMP238 expression is associated with concurrent chemoradiotherapy sensitivity in cervical carcinoma.
Title: [Significance and expression of S100A9 and NMP238 in cervical carcinoma tissues with different concurrent chemoradiotherapy sensitivities].
RUVBL1 and RUVBL2 control the abundance of Phosphatidylinositol 3-kinase (PI3K)-related protein kinases (PIKKs), and stimulate the formation of PIKK-containing molecular complexes, such as those involved in nonsense-mediated mRNA decay.
Title: AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.
Several experimental approaches were used to investigate the molecular architecture of the RuvBL1-RuvBL2 complex and the role of the ATPase-insert domain (domain II) for its assembly and stability.
Title: Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexes.
Reptin and Pontin protein levels are strictly controlled by a posttranslational mechanism involving proteasomal degradation of newly synthesized proteins.
Title: Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism.

Submit: New GeneRIF Correction See all (27)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Rev, p19	rev	HIV-1 Rev interacting protein, RuvB-like 1 (RUVBL1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with RUVBL1 is increased by RRE	PubMed
Tat, p14	tat	The core of the p400/TRRAP complex, consists of BAF53A, P400, RUVBL1, RUVBL2, TRRAP, are identified to interact with HIV-1 Tat in Jurkat cell	PubMed
pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with RuvB-like 1 (RUVBL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_003698.1	NC_000011.8	CD82	BIND	PubMed	RUVBL1 (pontin) interacts with the CD82 (KAI1) promoter.
NP_003698.1		KAT5	BIND	PubMed	HTATIP (Tip60) interacts with RUVBL1 (pontin).
NP_003698.1	NC_000019.8	KLK3	BIND	PubMed	RUVBL1 (pontin) interacts with the KLK3 (PSA) promoter.
Q9Y265	O96019	ACTL6A	HPRD	PubMed
Q9Y265	P35222	CTNNB1	HPRD	PubMed
Q9Y265	Q9P2H0	KIAA1377	HPRD	PubMed
Q9Y265	Q9NV56	MRGBP	HPRD	PubMed
Q9Y265	P00747	PLG	HPRD	PubMed
Q9Y265	Q9Y230	RUVBL2	HPRD	PubMed
Q9Y265	P20226	TBP	HPRD	PubMed
BioGRID:114166	BioGRID:106575	ACTB	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:114166	BioGRID:106586	ACTG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:106601	ACTL6A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BioGRID:114166	BioGRID:122993	ACTR5	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:114166	BioGRID:125062	ACTR8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:106862	AR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:107009	ATP6V1B2	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:107074	BCL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:125706	C12orf45	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:123217	C2orf44	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114166	BioGRID:107243	CAD	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:120937	CAND1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:107276	CAPNS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:120526	CCDC87	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:107433	CDC42	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:107459	CDK9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:107487	CENPA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:116183	COPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:114166	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:116454	DDX42	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:108080	DKC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114166	BioGRID:121004	DMAP1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BioGRID:114166	BioGRID:108116	DNASE2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:117415	DPCD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:126855	E2F7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:971788	EBNA-LP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:121676	EP400	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:114166	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:108399	FBL	BioGRID	PubMed	Reconstituted Complex
BioGRID:114166	BioGRID:117646	FBXO25	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:108516	FDFT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109040	GNAS	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:116452	GPN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109127	GRK5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:109269	H2AFZ	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109315	HDAC1	BioGRID	PubMed	Biochemical Activity; Negative Genetic
BioGRID:114166	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109318	HDGF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109341	HINT1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114166	BioGRID:120635	HJURP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109351	HLA-B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109537	HSPA1L	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109544	HSPA8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:109701	IGF1R	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:120041	ING3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114166	BioGRID:120076	INO80	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:114166	BioGRID:123646	INO80B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:125928	INO80C	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:120238	INO80D	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:129701	INO80E	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:114353	IQGAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114166	BioGRID:109954	KCND3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:121617	KIAA1377	BioGRID	PubMed	Two-hybrid
BioGRID:114166	BioGRID:110035	KPNB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:119354	LEF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:113852	LZTR1	BioGRID	PubMed	Two-hybrid
BioGRID:114166	BioGRID:115710	MCRS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:121122	MEPCE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:124936	METTL18	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:117403	METTL21B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:110438	MLH1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:110455	MME	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:116134	MORF4L1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:115001	MORF4L2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:120548	MRGBP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:108757	MTOR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
BioGRID:114166	BioGRID:110811	NEDD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:110864	NFRKB	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:114166	BioGRID:124011	NTPCR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:117807	NUFIP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114166	BioGRID:203509	Nhp2l1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:114055	OFD1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114166	BioGRID:115252	PAN2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:111126	PCBP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:111127	PCBP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:119851	PCBP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:119818	PELO	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:120343	PIH1D1	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:114166	BioGRID:111404	PMS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:111657	PSMA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:111675	PSMC3	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:111679	PSMC6	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:114513	PSTPIP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:228650	Prpf8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:111849	RARA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:112022	RORA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:122783	RPAP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:114166	RUVBL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114166	BioGRID:116067	RUVBL2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
BioGRID:114166	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112478	SMARCA1	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:112479	SMARCA2	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:114045	SMARCA5	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:121244	SMARCAD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112485	SMARCC2	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:115574	SMNDC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112540	SOX2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:116058	SRCAP	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:112595	SRI	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112325	SRSF2	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:117619	STAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:108354	STOM	BioGRID	PubMed	Reconstituted Complex
BioGRID:114166	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112743	TAF9	BioGRID	PubMed	Reconstituted Complex
BioGRID:114166	BioGRID:112771	TBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:114166	BioGRID:115223	TELO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112871	TERC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114166	BioGRID:112874	TERT	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:114166	BioGRID:118931	TFPT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112938	TK1	BioGRID	PubMed	Two-hybrid
BioGRID:114166	BioGRID:120115	TMED9	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:113900	TRRAP	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:114166	BioGRID:115030	TTI1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:123164	TTI2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:115791	UBD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:113177	UBE2I	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114166	BioGRID:123263	UBXN6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:119509	UCHL5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:1678002	UL27	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:113867	USP9X	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:112804	VPS72	BioGRID	PubMed	Co-fractionation
BioGRID:114166	BioGRID:113761	YEATS4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:113360	YY1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
BioGRID:114166	BioGRID:1205538	gag-pol	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:1205542	rev	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114166	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex
BioGRID:114166	BioGRID:97916	tubgcp3	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
C-MYC pathway, organism-specific biosystem
C-MYC pathway
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Chromosome Maintenance, organism-specific biosystem (from REACTOME)
Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem (from REACTOME)
Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystemEukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophas...
Extension of Telomeres, organism-specific biosystem (from REACTOME)
Extension of Telomeres, organism-specific biosystemTelomerase acts as reverse transcriptase in the elongation of telomeres (Smogorzewska and de Lange 2004).
Gastric cancer network 1, organism-specific biosystem (from WikiPathways)
Gastric cancer network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
Nucleosome assembly, organism-specific biosystem (from REACTOME)
Nucleosome assembly, organism-specific biosystemThe formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A).
Telomere Extension By Telomerase, organism-specific biosystem (from REACTOME)
Telomere Extension By Telomerase, organism-specific biosystemHumans, like most eukaryotic organisms, add direct repeats to the telomere using a specialized DNA polymerase called telomerase. Telomerase is a ribonucleoprotein (RNP) complex minimally composed of...
Telomere Maintenance, organism-specific biosystem (from REACTOME)
Telomere Maintenance, organism-specific biosystemTelomeres are protein-DNA complexes at the ends of linear chromosomes that are important for genome stability. Telomeric DNA in humans, as in many eukaryotic organisms, consists of tandem repeats (B...
Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
Validated targets of C-MYC transcriptional activation, organism-specific biosystem
Validated targets of C-MYC transcriptional activation
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

General gene information

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Markers

D3S4244 (e-PCR)
- UniSTS:57420

PMC24527P1 (e-PCR)
- UniSTS:272258

RH26475 (e-PCR)
- UniSTS:88506

Homology

Homologs of the RUVBL1 gene: The RUVBL1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
NOT ATPase activity	IDA Inferred from Direct Assay more info	PubMed
DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
CENP-A containing nucleosome assembly at centromere	TAS Traceable Author Statement more info
DNA duplex unwinding	IDA Inferred from Direct Assay more info	PubMed
DNA recombination	IEA Inferred from Electronic Annotation more info
DNA repair	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
histone H2A acetylation	IDA Inferred from Direct Assay more info	PubMed
histone H4 acetylation	IDA Inferred from Direct Assay more info	PubMed
mitosis	IEA Inferred from Electronic Annotation more info
nucleosome assembly	TAS Traceable Author Statement more info
regulation of growth	IEA Inferred from Electronic Annotation more info
regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
spermatogenesis	TAS Traceable Author Statement more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info
Ino80 complex	IDA Inferred from Direct Assay more info	PubMed
MLL1 complex	IDA Inferred from Direct Assay more info	PubMed
NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
membrane	IEA Inferred from Electronic Annotation more info
microtubule organizing center	IEA Inferred from Electronic Annotation more info
nuclear matrix	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: ruvB-like 1

Names: ruvB-like 1; ECP-54; NMP 238; pontin 52; TAP54-alpha; INO80 complex subunit H; nuclear matrix protein 238; RuvB (E coli homolog)-like 1; 49 kDa TBP-interacting protein; TIP60-associated protein 54-alpha; 54 kDa erythrocyte cytosolic protein; TATA binding protein interacting protein 49 kDa; 49 kDa TATA box-binding protein-interacting protein

NP_003698.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003707.2 → NP_003698.1 ruvB-like 1

Status: VALIDATED

Source sequence(s)

AW069473, BC002993, DA530328

Consensus CDS

CCDS3047.1

UniProtKB/Swiss-Prot

Q9Y265

Related

ENSP00000318297, OTTHUMP00000216127, ENST00000322623, OTTHUMT00000356728

Conserved Domains (2) summary

cd00009
Location:40 – 123
Blast Score: 122

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

pfam06068
Location:14 – 416
Blast Score: 1774

TIP49; TIP49 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p10 Primary Assembly

Range

127799800..127842671, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

125180247..125223118, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018914.1 Alternate CHM1_1.0

Range

127775389..127818258, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01020888.1 (28555..68717)	None
genomic	ABBA01020889.1	None
genomic	AC069419.20 (16018..58857)	None
genomic	AF380344.1	AAM45570.1
genomic	AMYH01013461.1 (22737..65606)	None
genomic	CH471052.2	EAW79323.1
mRNA	AB012122.1	BAA28169.1
mRNA	AB451224.1	BAG70038.1
mRNA	AB451347.1	BAG70161.1
mRNA	AF070735.1	AAC77819.1
mRNA	AF099084.1	AAD04427.1
mRNA	AJ010058.1	CAA08986.1
mRNA	AK092163.1	BAG52489.1
mRNA	AK222563.1	BAD96283.1
mRNA	AK222575.1	BAD96295.1
mRNA	AK312290.1	BAG35217.1
mRNA	AW069473.1	None
mRNA	BC002993.1	AAH02993.1
mRNA	BC012886.1	AAH12886.1
mRNA	BT007057.1	AAP35706.1
mRNA	DA530328.1	None
mRNA	DQ469310.1	ABF13334.1
mRNA	Y18418.1	CAB46271.1
other-genetic	DQ891448.2	ABM82374.1
other-genetic	DQ894627.2	ABM85553.1