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PLA2G4C phospholipase A2 group IVC [ Homo sapiens (human) ]

Gene ID: 8605, updated on 8-May-2016
Official Symbol
PLA2G4Cprovided by HGNC
Official Full Name
phospholipase A2 group IVCprovided by HGNC
Primary source
HGNC:HGNC:9037
See related
Ensembl:ENSG00000105499 HPRD:04673; MIM:603602; Vega:OTTHUMG00000183185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPLA2-gamma
Summary
This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Orthologs
Location:
19q13.3
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (48047843..48110853, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48551100..48614109, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene epididymal sperm binding protein 1 Neighboring gene calcium binding protein 5 Neighboring gene DNA ligase 1 Neighboring gene chromosome 19 open reading frame 68 Neighboring gene caspase recruitment domain family member 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
Tat tat HIV-1 Tat upregulates phospholipase A2, group IVC (PLA2G4C) expression in Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

  • Acyl chain remodelling of PC, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PC, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylcholine (PC) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid compos...
  • Acyl chain remodelling of PE, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PE, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid ...
  • Acyl chain remodelling of PI, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PI, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylinositol (PI) is hydrolyzed by phospholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid comp...
  • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
    Arachidonic acid metabolism, organism-specific biosystem
    Arachidonic acid metabolism
  • Arachidonic acid metabolism, conserved biosystem (from KEGG)
    Arachidonic acid metabolism, conserved biosystem
    Arachidonic acid metabolism
  • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
    Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Choline metabolism in cancer, conserved biosystem (from KEGG)
    Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
  • Ether lipid metabolism, organism-specific biosystem (from KEGG)
    Ether lipid metabolism, organism-specific biosystem
    Ether lipid metabolism
  • Ether lipid metabolism, conserved biosystem (from KEGG)
    Ether lipid metabolism, conserved biosystem
    Ether lipid metabolism
  • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
    Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
  • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
    Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
    Glycerophospholipid metabolism, organism-specific biosystem
    Glycerophospholipid metabolism
  • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
    Glycerophospholipid metabolism, conserved biosystem
    Glycerophospholipid metabolism
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • Hydrolysis of LPC, organism-specific biosystem (from REACTOME)
    Hydrolysis of LPC, organism-specific biosystemLysophosphatidylcholine (LPC) is hydrolyzed by phospholipases to produce glycerophosphocholine (GPCho) which is in turn hydrolyzed by glycerophosphocholine phosphodiesterase to produce choline (Cho) ...
  • Hydrolysis of LPE, organism-specific biosystem (from REACTOME)
    Hydrolysis of LPE, organism-specific biosystemLysophosphatidylethanolamine (LPE) is hydrolyzed by phospholipases to produce glycerophosphoethanolamine (GPETA) which is in turn hydrolyzed by glycerophosphocholine phosphodiesterase to produce etha...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Linoleic acid metabolism, organism-specific biosystem (from KEGG)
    Linoleic acid metabolism, organism-specific biosystem
    Linoleic acid metabolism
  • Linoleic acid metabolism, conserved biosystem (from KEGG)
    Linoleic acid metabolism, conserved biosystem
    Linoleic acid metabolism
  • Long-term depression, organism-specific biosystem (from KEGG)
    Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • Long-term depression, conserved biosystem (from KEGG)
    Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
    Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Ovarian steroidogenesis, conserved biosystem (from KEGG)
    Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • VEGF signaling pathway, organism-specific biosystem (from KEGG)
    VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGF signaling pathway, conserved biosystem (from KEGG)
    VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • alpha-Linolenic acid metabolism, organism-specific biosystem (from KEGG)
    alpha-Linolenic acid metabolism, organism-specific biosystem
    alpha-Linolenic acid metabolism
  • alpha-Linolenic acid metabolism, conserved biosystem (from KEGG)
    alpha-Linolenic acid metabolism, conserved biosystem
    alpha-Linolenic acid metabolism
  • phospholipases, organism-specific biosystem (from BIOCYC)
    phospholipases, organism-specific biosystem
    phospholipases
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ42247, FLJ44164, DKFZp586C0423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
lysophospholipase activity TAS
Traceable Author Statement
more info
 
phosphatidylcholine 1-acylhydrolase activity TAS
Traceable Author Statement
more info
 
phospholipase A2 activity TAS
Traceable Author Statement
more info
 
phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
glycerophospholipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
parturition NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytosolic phospholipase A2 gamma
Names
phospholipase A2, group IVC (cytosolic, calcium-independent)
NP_001152794.1
NP_001152795.1
NP_003697.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016021.1 RefSeqGene

    Range
    5001..68010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159322.1NP_001152794.1  cytosolic phospholipase A2 gamma isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC010458, AC011466, AK295400
    Consensus CDS
    CCDS59403.1
    UniProtKB/Swiss-Prot
    Q9UP65
    Related
    ENSP00000472546, OTTHUMP00000271126, ENST00000599111, OTTHUMT00000465548
    Conserved Domains (1) summary
    cd07202
    Location:19539
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
  2. NM_001159323.1NP_001152795.1  cytosolic phospholipase A2 gamma isoform 3

    See identical proteins and their annotated locations for NP_001152795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC010458, AC011466, AK022440
    Consensus CDS
    CCDS54286.1
    UniProtKB/Swiss-Prot
    Q9UP65
    Related
    ENSP00000346228, OTTHUMP00000271127, ENST00000354276, OTTHUMT00000465549
    Conserved Domains (1) summary
    cd07202
    Location:4527
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
  3. NM_003706.2NP_003697.2  cytosolic phospholipase A2 gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_003697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AC010458, AC011466, BC063416
    Consensus CDS
    CCDS12710.1
    UniProtKB/Swiss-Prot
    Q9UP65
    UniProtKB/TrEMBL
    A0A024QZH0
    Related
    ENSP00000469473, OTTHUMP00000271128, ENST00000599921, OTTHUMT00000465551
    Conserved Domains (1) summary
    cd07202
    Location:4529
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    48047843..48110853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527431.1XP_011525733.1  

    Conserved Domains (1) summary
    cd07202
    Location:4511
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
  2. XM_011527434.1XP_011525736.1  

    Conserved Domains (1) summary
    cl11396
    Location:10350
    Patatin_and_cPLA2; Patatins and Phospholipases
  3. XM_011527432.1XP_011525734.1  

    Conserved Domains (1) summary
    cl11396
    Location:4425
    Patatin_and_cPLA2; Patatins and Phospholipases
  4. XM_011527433.1XP_011525735.1  

    See identical proteins and their annotated locations for XP_011525735.1

    Conserved Domains (1) summary
    cl11396
    Location:4253
    Patatin_and_cPLA2; Patatins and Phospholipases

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    48553058..48616286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)