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    SCARF1 scavenger receptor class F, member 1 [ Homo sapiens ]

    Gene ID: 8578, updated on 12-May-2012
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    Summary

    Official Symbol
    SCARF1provided by HGNC
    Official Full Name
    scavenger receptor class F, member 1provided by HGNC
    Primary source
    HGNC:16820
    See related
    Ensembl:ENSG00000074660; HPRD:06386; MIM:607873; Vega:OTTHUMG00000090555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREC; SREC1; SREC-I; KIAA0149; MGC47738
    Summary
    The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17p13.3
    Sequence :
    Chromosome: 17; NC_000017.10 (1537152..1549041, complement)
    See SCARF1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100306951 Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene solute carrier family 43, member 2 Neighboring gene Rab interacting lysosomal protein Neighboring gene PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I). Hölzl MA, et al. Cell Immunol, 2011. PMID 21190681.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. Berwin B, et al. J Biol Chem, 2004 Dec 3. PMID 15371419.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    5. SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. Ishii J, et al. J Biol Chem, 2002 Oct 18. PMID 12154095.

    See all (8) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. GP2 is a binding partner of the scavenger receptor expressed on endothelial cells I (SREC-I) but not of SR-AI and SR-BI. Dendritic cells express SREC-I and also bind and internalize GP2.
      Title: The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).
    2. SRECI binds to SRECII and has a similar tissue distribution pattern
      Title: SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain.
    3. Characterization of the gene and its regulation by a novel transcription factor, endothelial zinc protein-2
      Title: Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q14162 P27797 CALR    HPRD  PubMed  
    Q14162 Q96GP6 SCARF2    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    scavenger receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cholesterol catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    scavenger receptor class F member 1
    Names
    scavenger receptor class F member 1
    acetyl LDL receptor
    endothelial cells scavenger receptor
    scavenger receptor expressed by endothelial cells 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003693.2 → NP_003684.2  scavenger receptor class F member 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AW263037, BC039735
      Consensus CDS
      CCDS11007.1
      UniProtKB/Swiss-Prot
      Q14162
      Related
      ENSP00000263071, OTTHUMP00000115659, ENST00000263071, OTTHUMT00000207081

    2. NM_145350.1 → NP_663325.1  scavenger receptor class F member 1 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal segment in the coding region, which leads to a translation frameshift, as compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AB052948, AW263037, BC039735
      Consensus CDS
      CCDS45564.1
      UniProtKB/Swiss-Prot
      Q14162
      Related
      ENSP00000458174, ENST00000571272

    3. NM_145352.2 → NP_663327.2  scavenger receptor class F member 1 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (5) lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AC130343, BC039735
      Consensus CDS
      CCDS11008.1
      UniProtKB/Swiss-Prot
      Q14162
      Related
      ENSP00000323964, ENST00000348987

    RNA

    1. NR_028075.1 RNA Sequence

      Description
      Transcript Variant: This variant (2) uses an alternate splice site resulting in a frameshift, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB052947, AC130343, AK291810, AW263037, BC039735

    2. NR_028076.1 RNA Sequence

      Description
      Transcript Variant: This variant (4) retains an extra segment in the coding region which introduces an earlier stop codon, as compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB052947, AB052949, AC130343, AK291810, AW263037, BC039735

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      1537152..1549041, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      1436503..1448415, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB052946.1 BAC02692.1
    genomic AC130343.7 (83371..88439) None
    genomic CH471108.2 EAW90596.1
      EAW90597.1
      EAW90598.1
      EAW90599.1
      EAW90600.1
    mRNA AB052947.1 BAC02693.1
    mRNA AB052948.1 BAC02694.1
    mRNA AB052949.1 BAC02695.1
    mRNA AB052950.1 BAC02696.1
    mRNA AK291810.1 BAF84499.1
    mRNA AK298737.1 BAG60884.1
    mRNA AK308904.1 None
    mRNA AK310174.1 None
    mRNA AK311370.1 None
    mRNA AW263037.1 None
    mRNA BC039735.1 AAH39735.1
    mRNA D63483.1 BAA09770.1
    mRNA D86864.1 BAA24070.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14162.3 GenPept UniProtKB/Swiss-Prot:Q14162
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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