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CASK calcium/calmodulin dependent serine protein kinase [ Homo sapiens (human) ]

Gene ID: 8573, updated on 25-May-2016
Official Symbol
CASKprovided by HGNC
Official Full Name
calcium/calmodulin dependent serine protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:1497
See related
Ensembl:ENSG00000147044 HPRD:02164; MIM:300172; Vega:OTTHUMG00000021378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMG; FGS4; LIN2; TNRC8; CAGH39; CAMGUK; MICPCH; MRXSNA
Summary
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Orthologs
Location:
Xp11.4
Exon count:
28
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (41514934..41923078, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (41374187..41782415, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 3, X-linked Neighboring gene gem nuclear organelle associated protein 7 pseudogene Neighboring gene nyctalopin Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene Neighboring gene ribosomal protein S15a pseudogene 39 Neighboring gene G protein-coupled receptor 34 Neighboring gene G protein-coupled receptor 82 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) pseudogene 4 Neighboring gene uncharacterized LOC105373187 Neighboring gene uncharacterized LOC105373186

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
FG syndrome 4
MedGen: C1845546 OMIM: 300422 GeneReviews: Not available
Compare labs
Mental retardation and microcephaly with pontine and cerebellar hypoplasia
MedGen: C2677903 OMIM: 300749 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-06-28)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-06-28)

ClinGen Genome Curation PagePubMed
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Dopamine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Dopamine Neurotransmitter Release Cycle, organism-specific biosystemDopamine neurotransmitter cycle occurs in dopaminergic neurons. Dopamine is synthesized and loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and fused w...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Nephrin interactions, organism-specific biosystem (from REACTOME)
    Nephrin interactions, organism-specific biosystemNephrin is a member of the Super-IgG-Molecule family and is most prominently expressed in kidney podocytes. It is a major if not the most important structural component of the slit diaphragm, a modif...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Neurotransmitter Release Cycle, organism-specific biosystemNeurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotr...
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
  • Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
    Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
  • Syndecan interactions, organism-specific biosystem (from REACTOME)
    Syndecan interactions, organism-specific biosystemSyndecans are type I transmembrane proteins, with an N-terminal ectodomain that contains several consensus sequences for glycosaminoglycan (GAG) attachment and a short C-terminal cytoplasmic domain. ...
  • Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-1-mediated signaling events, organism-specific biosystem
    Syndecan-1-mediated signaling events
  • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-2-mediated signaling events, organism-specific biosystem
    Syndecan-2-mediated signaling events
  • Syndecan-3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-3-mediated signaling events, organism-specific biosystem
    Syndecan-3-mediated signaling events
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22219, FLJ31914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
guanylate kinase activity TAS
Traceable Author Statement
more info
PubMed 
neurexin family protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GDP metabolic process IEA
Inferred from Electronic Annotation
more info
 
GMP metabolic process IEA
Inferred from Electronic Annotation
more info
 
calcium ion import IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of keratinocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear lamina IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
peripheral plasma membrane protein CASK
Names
calcium/calmodulin-dependent serin protein kinase
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase
hCASK
protein lin-2 homolog
trinucleotide repeat containing 8
NP_001119526.1
NP_001119527.1
NP_003679.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016754.1 RefSeqGene

    Range
    5001..413101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126054.2NP_001119526.1  peripheral plasma membrane protein CASK isoform 2

    See identical proteins and their annotated locations for NP_001119526.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (2) contains an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AB208859, AL445239, BC117311, DN993605
    Consensus CDS
    CCDS48095.1
    UniProtKB/Swiss-Prot
    O14936
    Related
    ENSP00000398007, OTTHUMP00000226872, ENST00000442742, OTTHUMT00000379057
    Conserved Domains (7) summary
    cd12081
    Location:593654
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:714879
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:710883
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:405454
    L27; L27 domain
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  2. NM_001126055.2NP_001119527.1  peripheral plasma membrane protein CASK isoform 3

    See identical proteins and their annotated locations for NP_001119527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and use an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AB208859, AF035582, AK313399, AL445239, BC117311
    Consensus CDS
    CCDS48094.1
    UniProtKB/Swiss-Prot
    O14936
    Related
    ENSP00000400526, OTTHUMP00000023159, ENST00000421587, OTTHUMT00000056282
    Conserved Domains (7) summary
    cd12081
    Location:587648
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:713878
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:482562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:709882
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:399448
    L27; L27 domain
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  3. NM_003688.3NP_003679.2  peripheral plasma membrane protein CASK isoform 1

    See identical proteins and their annotated locations for NP_003679.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AB208859, AF032119, AL445239, BC117311, DN993605
    Consensus CDS
    CCDS14257.1
    UniProtKB/Swiss-Prot
    O14936
    Related
    ENSP00000367408, OTTHUMP00000023160, ENST00000378166, OTTHUMT00000056283
    Conserved Domains (7) summary
    cd12081
    Location:616677
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:737902
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:733906
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:405454
    L27; L27 domain
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    41514934..41923078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724566.2XP_006724629.1  

    See identical proteins and their annotated locations for XP_006724629.1

    Conserved Domains (7) summary
    cd12081
    Location:575636
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:701866
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:482562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:697870
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:399448
    L27; L27 domain
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  2. XM_005272686.3XP_005272743.1  

    See identical proteins and their annotated locations for XP_005272743.1

    Conserved Domains (7) summary
    cd12081
    Location:610671
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:736901
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:482562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:732905
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:399448
    L27; L27 domain
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  3. XM_011543996.1XP_011542298.1  

    Conserved Domains (7) summary
    cd12081
    Location:581642
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:707872
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:703876
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:405454
    L27; L27 domain
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  4. XM_011543995.1XP_011542297.1  

    See identical proteins and their annotated locations for XP_011542297.1

    Conserved Domains (7) summary
    cd12081
    Location:593654
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:719884
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:715888
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:405454
    L27; L27 domain
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  5. XM_011543994.1XP_011542296.1  

    See identical proteins and their annotated locations for XP_011542296.1

    Conserved Domains (7) summary
    cd12081
    Location:604665
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:730895
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:726899
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:405454
    L27; L27 domain
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  6. XM_011543993.1XP_011542295.1  

    See identical proteins and their annotated locations for XP_011542295.1

    Conserved Domains (7) summary
    cd12081
    Location:616677
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:12282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:742907
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:738911
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:405454
    L27; L27 domain
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
  7. XM_011543997.1XP_011542299.1  

    Conserved Domains (7) summary
    cd12081
    Location:425486
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00220
    Location:191
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00071
    Location:551716
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:297377
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:547720
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:214263
    L27; L27 domain
    cl21453
    Location:1122
    PKc_like; Protein Kinases, catalytic domain

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    41406782..41814790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)