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UBC6 E2 ubiquitin-conjugating protein UBC6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856837, updated on 11-Apr-2024

Summary

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Gene symbol
UBC6
Gene description
E2 ubiquitin-conjugating protein UBC6
Primary source
SGD:S000000902
Locus tag
YER100W
See related
AllianceGenome:SGD:S000000902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DOA2
Summary
Enables ubiquitin-protein transferase activity. Involved in protein monoubiquitination; protein polyubiquitination; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum membrane. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (359562..360314)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP9 Neighboring gene ribose phosphate diphosphokinase subunit PRS2 Neighboring gene Ast2p Neighboring gene ribosomal 40S subunit protein S8B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein. Mayer TU, et al. EMBO J, 1998 Jun 15. PMID 9628862, Free PMC Article
  2. The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum. Yang M, et al. J Biol Chem, 1997 Jan 17. PMID 8999888
  3. Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast. Jakob CA, et al. EMBO Rep, 2001 May. PMID 11375935, Free PMC Article
  4. Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase. Weber A, et al. Mol Cell, 2016 Sep 1. PMID 27570077
  5. An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme. Kreft SG, et al. J Biol Chem, 2011 Jun 10. PMID 21467040, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sequential poly-ubiquitylation by specialized conjugating enzymes Ubc6 and Ubc7 expands the versatility of a quality control ubiquitin ligase Doa10.
    Title: Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E2 ubiquitin-conjugating protein UBC6
NP_011026.3
  • Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    359562..360314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178991.3 → NP_011026.3  TPA: E2 ubiquitin-conjugating protein UBC6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011026.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM07, P33296
    UniProtKB/TrEMBL
    A0A8H8ULW7, A6ZR56, B3LRL8, B5VHM6, C7GVH2, C8Z7B8, G2WD23, N1PA51
    Conserved Domains (1) summary
    COG5078
    Location:1 → 154
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33296.1

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