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PTC2 Ptc2p [ Saccharomyces cerevisiae S288c ]

Gene ID: 856823, updated on 17-Aug-2014
Gene symbol
PTC2
Gene description
Ptc2p
Primary source
SGD:S000000891
Locus tag
YER089C
Gene type
protein coding
RNA name
Ptc2p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See PTC2 in MapViewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (335946..337340, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Sbh1p Neighboring gene Dot6p Neighboring gene anthranilate synthase TRP2 Neighboring gene 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Names
Ptc2p
NP_011013.1
  • Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 

    Range
    335946..337340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178980.1NP_011013.1  Ptc2p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_011013.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P39966
    Conserved Domains (1) summary
    cd00143
    Location:24292
    Blast Score: 635
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...