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SBH2 Arf family guanine nucleotide exchange factor SBH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856740, updated on 13-Apr-2024

Summary

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Gene symbol
SBH2
Gene description
Arf family guanine nucleotide exchange factor SBH2
Primary source
SGD:S000002127
Locus tag
YER019C-A
See related
AllianceGenome:SGD:S000002127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SEB2
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in nuclear inner membrane. Part of Ssh1 translocon complex. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (194273..194539, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene kinetochore-associated Ndc80 complex subunit SPC25 Neighboring gene inositol phosphosphingolipid phospholipase Neighboring gene guanine nucleotide-binding protein subunit alpha Neighboring gene proteasome regulatory particle lid subunit RPN3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The beta-subunit of the protein-conducting channel of the endoplasmic reticulum functions as the guanine nucleotide exchange factor for the beta-subunit of the signal recognition particle receptor. Helmers J, et al. J Biol Chem, 2003 Jun 27. PMID 12750387
  2. Mechanism of polypeptide translocation into the endoplasmic reticulum. Corsi AK, et al. J Biol Chem, 1996 Nov 29. PMID 8939984
  3. Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome. Becker T, et al. Science, 2009 Dec 4. PMID 19933108, Free PMC Article
  4. Kluyveromyces lactis SSO1 and SEB1 genes are functional in Saccharomyces cerevisiae and enhance production of secreted proteins when overexpressed. Toikkanen JH, et al. Yeast, 2004 Sep. PMID 15449305
  5. Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit. Toikkanen J, et al. Yeast, 1996 Apr. PMID 8740416

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ssh1 translocon complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Arf family guanine nucleotide exchange factor SBH2
NP_010936.1
  • Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    194273..194539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180031.1 → NP_010936.1  TPA: Arf family guanine nucleotide exchange factor SBH2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLR8, P52871, Q53X22
    UniProtKB/TrEMBL
    A0A6A5Q0H4, A6ZQW8, B3LS32, C7GKJ8, C8Z720, G2WCQ2, N1P3Y4
    Conserved Domains (1) summary
    pfam03911
    Location:45 → 81
    Sec61_beta; Sec61beta family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52871.1

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