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EAF5 Eaf5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856696, updated on 13-Apr-2024

Summary

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Gene symbol
EAF5
Gene description
Eaf5p
Primary source
SGD:S000000744
Locus tag
YEL018W
See related
AllianceGenome:SGD:S000000744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in DNA repair. Located in cytosol and nucleus. Part of NuA4 histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (121471..122310)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative indolepyruvate decarboxylase family protein Neighboring gene SUMO ligase MMS21 Neighboring gene proteolipid ATPase Neighboring gene Gtt3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Nourani A, et al. Mol Cell Biol, 2001 Nov. PMID 11604499, Free PMC Article
  2. Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins. Tanaka S. Genetics, 2021 Mar 3. PMID 33683348, Free PMC Article
  3. NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Ginsburg DS, et al. Mol Cell Biol, 2009 Dec. PMID 19822662, Free PMC Article
  4. Structure of the NuA4 histone acetyltransferase complex. Ji L, et al. Proc Natl Acad Sci U S A, 2022 Nov 29. PMID 36417436, Free PMC Article
  5. Structure and flexibility of the yeast NuA4 histone acetyltransferase complex. Zukin SA, et al. Elife, 2022 Oct 20. PMID 36263929, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vitro binding assays showed that Eaf3/5/7 specifically stimulates NuA4 binding to di- and trimethylated histone H3 Lys-36 and that this binding is important for NuA4 occupancy in transcribed ORFs.
    Title: The Eaf3/5/7 Subcomplex Stimulates NuA4 Interaction with Methylated Histone H3 Lys-36 and RNA Polymerase II.
  2. Eaf5 and Eaf7 form a subcomplex. Eaf7 interacts with NuA4 through Eaf5.
    Title: Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Eaf5p
NP_010897.1
  • Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    121471..122310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178833.1 → NP_010897.1  TPA: Eaf5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010897.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLN1, P39995
    UniProtKB/TrEMBL
    A0A6A5PY18, A6ZQT1, B3LRZ8, B5VHB9, C7GX25, C8Z6Y1, G2WCL4, N1PA76
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5Y81_H.1
P39995.1

Gene LinkOut

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