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IMD2 IMP dehydrogenase IMD2 [ Saccharomyces cerevisiae S288c ]

Gene ID: 856626, updated on 3-Apr-2016
Gene symbol
IMD2
Gene description
IMP dehydrogenase IMD2
Primary source
SGD:S000001259
Locus tag
YHR216W
Gene type
protein coding
RNA name
IMP dehydrogenase IMD2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PUR5
See IMD2 in Map Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (554396..555967)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene acid phosphatase PHO12 Neighboring gene hypothetical protein Neighboring gene hypothetical protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
IMP dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
IMP dehydrogenase activity TAS
Traceable Author Statement
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GTP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Names
IMP dehydrogenase IMD2
NP_012088.3
  • Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    554396..555967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179347.3NP_012088.3  IMP dehydrogenase IMD2 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_012088.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38697
    Conserved Domains (3) summary
    cd00381
    Location:36492
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:122233
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:21518
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional