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    TRA1 Tra1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 856499, updated on 21-May-2012
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    Summary

    Gene symbol
    TRA1
    Gene description
    Tra1p
    Primary source
    SGD:S000001141
    Locus tag
    YHR099W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: VIII
    Sequence :
    Chromosome: VIII; NC_001140.6 (302761..313995)
    See TRA1 in MapViewer

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Sfb3p Neighboring gene Gep4p Neighboring gene Big1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1. Kvas S, et al. BMC Genet, 2012 Mar 22. PMID 22439631.
    2. Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4. Lin L, et al. Proc Natl Acad Sci U S A, 2012 Feb 7. PMID 22308403.
    3. Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses. Gilmore JM, et al. Mol Cell Proteomics, 2012 Apr. PMID 22199229.
    4. Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes. Chittuluru JR, et al. Nat Struct Mol Biol, 2011 Oct 9. PMID 21984211.
    5. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Lee KK, et al. Mol Syst Biol, 2011 Jul 5. PMID 21734642.

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Tra1 recruitment at Gcn4-dependent and Rap1-dependent promoters requires the same regions of Tra1, and separate regions of Tra1 contribute to the HAT activity and stability of the SAGA and NuA4 HAT modules.
      Title: Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.
    2. findings demonstrate the importance of the FATC domain in the structure/function of Tra1
      Title: Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.
    3. Genetic interactions have been identified which link Tra1 protein to gene expression, mitochondrial function, and membrane sorting/protein trafficking.
      Title: Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_011967.1 NP_010907.1 GCN4    BIND  PubMed Gcn4 interacts with Tra1. 
    BioGRID:36532 BioGRID:32503 ADA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:32269 ADR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:32891 AIM4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:33675 ARP4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:36532 BioGRID:34319 ATG34    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:33817 CBF1    BioGRID  PubMed PCA 
    BioGRID:36532 BioGRID:36917 CHD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:36001 CTI6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:32415 EAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:36200 EAF3    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:36712 EAF5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:36532 BioGRID:33837 EAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35690 EAF7    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:31122 EPL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure 
    BioGRID:36532 BioGRID:34635 ESA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:36532 BioGRID:35755 FKH2    BioGRID  PubMed PCA 
    BioGRID:36532 BioGRID:34353 GAL11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:36532 BioGRID:35915 GAL4    BioGRID  PubMed Affinity Capture-Western; FRET; PCA; Two-hybrid 
    BioGRID:36532 BioGRID:36723 GCN4    BioGRID  PubMed Affinity Capture-Western; PCA 
    BioGRID:36532 BioGRID:33503 GCN5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:34024 HAP4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:36532 BioGRID:35805 HDA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36532 BioGRID:35909 HFI1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:36532 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:36532 BioGRID:33176 HSF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:32277 HTA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:36532 BioGRID:32699 HTA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:36532 BioGRID:34392 HTZ1    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:36517 KSP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35216 MCM1    BioGRID  PubMed PCA 
    BioGRID:36532 BioGRID:31542 MCM5    BioGRID  PubMed Dosage Rescue 
    BioGRID:36532 BioGRID:36242 MED1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:36099 MOT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35001 MSL1    BioGRID  PubMed Two-hybrid 
    BioGRID:36532 BioGRID:34071 MSN4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35256 NAM7    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36532 BioGRID:32229 NGG1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:32052 NHP10    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36532 BioGRID:36511 NMD2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36532 BioGRID:31832 NOP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35620 RAP1    BioGRID  PubMed Co-localization 
    BioGRID:36532 BioGRID:33096 RCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:32751 REB1    BioGRID  PubMed PCA 
    BioGRID:36532 BioGRID:31921 RPO21    BioGRID  PubMed Co-localization 
    BioGRID:36532 BioGRID:32355 RSC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:32600 RTG3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:33659 SAP185    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:31660 SFP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:36532 BioGRID:36133 SGF11    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:30971 SGF29    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:33181 SGF73    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:32561 SMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:34678 SNF2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36532 BioGRID:32291 SNU56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:36897 SPT15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:34269 SPT20    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Lethality 
    BioGRID:36532 BioGRID:32454 SPT3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:32783 SPT7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification 
    BioGRID:36532 BioGRID:31330 SPT8    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:35644 SRP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:36987 SUS1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:36532 BioGRID:33246 SWC4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:36532 BioGRID:32200 SWI5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:32218 TAF10    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:36532 BioGRID:32199 TAF12    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:36532 BioGRID:32895 TAF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:33139 TAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35405 TAF7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35414 TAF9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:36532 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35401 UBP8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Growth Defect 
    BioGRID:36532 BioGRID:33315 UPF3    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36532 BioGRID:36319 URN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:35717 YAF9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:36532 BioGRID:35163 YAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36532 BioGRID:36525 YNG2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:36532 BioGRID:33698 ZAP1    BioGRID  PubMed PCA 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone acetylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    ASTRA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NuA4 histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SLIK (SAGA-like) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Tra1p
    NP_011967.1
    • Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6

      Range
      302761..313995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179229.1 → NP_011967.1  Tra1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P38811
      Conserved Domains (3) summary
      COG5032
      Location:1232 – 3744
      Blast Score: 2863
      TEL1; Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular ...
      cd05163
      Location:3371 – 3676
      Blast Score: 808
      TRRAP; TRansformation/tRanscription domain-Associated Protein (TRRAP), pseudokinase domain; The TRRAP catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
      pfam02260
      Location:3712 – 3744
      Blast Score: 104
      FATC; FATC domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006934.2 DAA06793.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38811.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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