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IPI1 Ipi1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856485, updated on 13-Apr-2024

Summary

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Gene symbol
IPI1
Gene description
Ipi1p
Primary source
SGD:S000001127
Locus tag
YHR085W
See related
AllianceGenome:SGD:S000001127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin binding activity. Involved in pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-dependent DNA replication initiation; and ribosomal large subunit biogenesis. Located in cytosol and nucleoplasm. Part of Rix1 complex. Orthologous to human TEX10 (testis expressed 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (276764..277768)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene SAM complex subunit SAM35 Neighboring gene homeodomain family transcription factor STE12 Neighboring gene Nam8p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits. Galani K, et al. J Biol Chem, 2004 Dec 31. PMID 15528184
  2. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Wu LF, et al. Nat Genet, 2002 Jul. PMID 12089522
  3. A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Nissan TA, et al. Mol Cell, 2004 Jul 23. PMID 15260980
  4. Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling. Barrio-Garcia C, et al. Nat Struct Mol Biol, 2016 Jan. PMID 26619264
  5. The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Huo L, et al. Cell Cycle, 2012 Apr 1. PMID 22421151

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study identified the Rix1 complex members (Ipi1p-Ipi2p/Rix1-Ipi3p) as pre-replicative complex components and critical determinants of replication licensing and replication-initiation frequency
    Title: The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of rixosome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of rixosome complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ipi1p
NP_011953.1
  • Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    276764..277768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179215.1 → NP_011953.1  TPA: Ipi1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011953.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZSZ4, D3DL36, P38803
    UniProtKB/TrEMBL
    A0A6A5PZN9, B3LSK2, B5VK17, C7GWU8, C8Z9M9, G2WFF9, N1P4K7
    Conserved Domains (1) summary
    pfam12333
    Location:125 → 216
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38803.1

Gene LinkOut

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