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SAM35 SAM complex subunit SAM35 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856483, updated on 13-Apr-2024

Summary

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Gene symbol
SAM35
Gene description
SAM complex subunit SAM35
Primary source
SGD:S000001125
Locus tag
YHR083W
See related
AllianceGenome:SGD:S000001125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FMP20; TOB38; TOM38
Summary
Involved in mitochondrial outer membrane translocase complex assembly and protein insertion into mitochondrial outer membrane. Located in mitochondrial outer membrane. Part of SAM complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (272627..273616)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Lrp1p Neighboring gene putative serine/threonine protein kinase KSP1 Neighboring gene homeodomain family transcription factor STE12 Neighboring gene Ipi1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. Milenkovic D, et al. J Biol Chem, 2004 May 21. PMID 15067005
  2. Membrane protein insertion through a mitochondrial β-barrel gate. Höhr AIC, et al. Science, 2018 Jan 19. PMID 29348211, Free PMC Article
  3. The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria. Körner C, et al. Mol Biol Cell, 2012 Jun. PMID 22496419, Free PMC Article
  4. Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. Waizenegger T, et al. EMBO Rep, 2004 Jul. PMID 15205677, Free PMC Article
  5. Assembly of the TOB complex of mitochondria. Habib SJ, et al. J Biol Chem, 2005 Feb 25. PMID 15590639

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assembly of newly synthesized Tob55 into preexisting TOB complexes depended on Tob38 but did not require Mas37
    Title: Assembly of the TOB complex of mitochondria.
  2. Tob38 has a crucial function in the biogenesis of beta-barrel proteins of mitochondria
    Title: Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial outer membrane translocase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein insertion into mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAM complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAM complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SAM complex subunit SAM35
NP_011951.1
  • Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    272627..273616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179213.1 → NP_011951.1  TPA: SAM complex subunit SAM35 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011951.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL34, P14693
    UniProtKB/TrEMBL
    A0A8H4F9V9, A6ZSZ2, N1P126
    Conserved Domains (1) summary
    pfam10806
    Location:5 → 133
    SAM35; subunit of SAM coomplex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
7E4H_B.1
7E4I_B.1
P14693.2

Gene LinkOut

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