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    SOD2 Sod2p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 856399, updated on 21-May-2012
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    Summary

    Gene symbol
    SOD2
    Gene description
    Sod2p
    Primary source
    SGD:S000001050
    Locus tag
    YHR008C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: VIII
    Sequence :
    Chromosome: VIII; NC_001140.6 (122889..123590, complement)
    See SOD2 in MapViewer

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Erg11p Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene Rpl27ap

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    2. La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast. Schenk L, et al. RNA, 2012 Mar. PMID 22271760.
    3. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Alkhaja AK, et al. Mol Biol Cell, 2012 Jan. PMID 22114354.
    4. Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae. Kang Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Oct 1. PMID 22102021.
    5. Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans. Sheng Y, et al. J Am Chem Soc, 2011 Dec 28. PMID 22077216.

    See all (53) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. surface-potential distribution of SOD2 revealed a conserved positively charged electrostatic zone in the proximity of the active site
      Title: Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae.
    2. Data find that misincorporation of iron into yeast Sod2p does not correlate with significant changes in the average oxidation state or coordination chemistry of bulk mitochondrial iron.
      Title: The interaction of mitochondrial iron with manganese superoxide dismutase.
    3. Inactivation of SOD1 and SOD2 modifies response to S-nitrosoglutathione-induced stress.
      Title: Inactivation of genes encoding superoxide dismutase modifies yeast response to S-nitrosoglutathione-induced stress.
    4. sod 2 Delta and sod 1 Deltasod 2 Delta demonstrated the highest levels of GSH in the control, suggesting that pathways which include GSH protect these double mutants against oxidative stress
      Title: Adaptative response to enhanced basal oxidative damage in sod mutants from Saccharomyces cerevisiae.
    5. the insertion of manganese into eukaryotic SOD2 molecules is driven by the protein unfolding process associated with mitochondrial import
      Title: Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae.
    6. neither MnSOD nor CuZnSOD is required for protecting the majority of mitochondrial proteins from oxidative damage during early phases of growth
      Title: Mitochondrial protein oxidation in yeast mutants lacking manganese-(MnSOD) or copper- and zinc-containing superoxide dismutase (CuZnSOD): evidence that MnSOD and CuZnSOD have both unique and overlapping functions in protecting mitochondrial proteins from oxidative damage.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:36435 BioGRID:31569 ACO1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:31107 ACT1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32320 AKR1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32814 ALG1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32984 BSD2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36435 BioGRID:30980 CDC10    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:34387 CMK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:36435 BioGRID:33752 CYR1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36435 BioGRID:32898 DER1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32972 DPB3    BioGRID  PubMed Positive Genetic 
    BioGRID:36435 BioGRID:32780 ECM33    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:34148 FCJ1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:35951 FUM1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32336 GCN2    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:33503 GCN5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:34600 GEP3    BioGRID  PubMed Positive Genetic 
    BioGRID:36435 BioGRID:32151 GIS1    BioGRID  PubMed Dosage Rescue; Phenotypic Suppression 
    BioGRID:36435 BioGRID:31773 GPB2    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:36333 GPH1    BioGRID  PubMed Dosage Rescue 
    BioGRID:36435 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:36435 BioGRID:35473 HER2    BioGRID  PubMed Positive Genetic 
    BioGRID:36435 BioGRID:35066 HMG1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:33831 HOC1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:34321 IRA2    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:36046 ISU1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:33692 LAS21    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:34074 MPE1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:36553 MSH1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36435 BioGRID:35209 MSN2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36435 BioGRID:34071 MSN4    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36435 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:36435 BioGRID:32764 ORC2    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32531 PEX29    BioGRID  PubMed PCA 
    BioGRID:36435 BioGRID:31191 PHO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:33087 PMR1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36435 BioGRID:35445 PPA2    BioGRID  PubMed Positive Genetic 
    BioGRID:36435 BioGRID:33555 PRP21    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:31881 PTP1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:35048 RAD10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:36462 RRM3    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36435 BioGRID:35078 RSC9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:31249 RTT109    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36435 BioGRID:36639 SCH9    BioGRID  PubMed Phenotypic Suppression; Synthetic Rescue 
    BioGRID:36435 BioGRID:36096 SEC16    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:34644 SEC63    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:36133 SGF11    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:30971 SGF29    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:32017 SIR2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36435 BioGRID:112506 SNCA    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36435 BioGRID:33860 SOD1    BioGRID  PubMed Dosage Rescue; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:36435 BioGRID:36435 SOD2    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:36435 BioGRID:36698 SPF1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32851 SPP381    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:30946 SRO9    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:36435 BioGRID:31792 SWD1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:33266 THG1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:33823 TOR1    BioGRID  PubMed Dosage Rescue 
    BioGRID:36435 BioGRID:32129 TPS2    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:33437 TYS1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:35193 UBC7    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:32828 VMA2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36435 BioGRID:33348 VMA21    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36435 BioGRID:32103 VMS1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36435 BioGRID:33349 VOA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36435 BioGRID:30928 YCL057C-A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:31943 YFH1    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:33687 YJL068C    BioGRID  PubMed Positive Genetic 
    BioGRID:36435 BioGRID:35281 YKU80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36435 BioGRID:31614 YLR352W    BioGRID  PubMed Negative Genetic 
    BioGRID:36435 BioGRID:35542 YNL295W    BioGRID  PubMed PCA 
    BioGRID:36435 BioGRID:35264 YTA12    BioGRID  PubMed Phenotypic Suppression 
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    General gene information

    Homology

    • Homologs of the SOD2 gene: The SOD2 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, , N.crassa, A.thaliana, and rice.

    Pathways from BioSystems

    • Peroxisome, organism-specific biosystem (from KEGG)
      Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Peroxisome, conserved biosystem (from KEGG)
      Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    age-dependent response to oxidative stress involved in chronological cell aging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    age-dependent response to reactive oxygen species involved in chronological cell aging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Sod2p
    NP_011872.1
    • Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6

      Range
      122889..123590, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179138.1 → NP_011872.1  Sod2p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P00447
      Conserved Domains (3) summary
      COG0605
      Location:25 – 233
      Blast Score: 594
      SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
      pfam00081
      Location:29 – 115
      Blast Score: 254
      Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
      pfam02777
      Location:125 – 228
      Blast Score: 407
      Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006934.2 DAA06697.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00447.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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