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THOC5 THO complex 5 [ Homo sapiens (human) ]

Gene ID: 8563, updated on 4-May-2015
Official Symbol
THOC5provided by HGNC
Official Full Name
THO complex 5provided by HGNC
Primary source
HGNC:HGNC:19074
See related
Ensembl:ENSG00000100296; HPRD:16650; MIM:612733; Vega:OTTHUMG00000151291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fmip; PK1.3; fSAP79; C22orf19
Orthologs
See THOC5 in MapViewer
Location:
22q12.2
Exon count:
24
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (29508167..29553760, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29904156..29949749, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RFPL1 antisense RNA 1 Neighboring gene ret finger protein-like 1 Neighboring gene neurofilament, heavy polypeptide Neighboring gene nipsnap homolog 1 (C. elegans) Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 4 Neighboring gene neurofibromin 2 (merlin)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
NHGRI GWA Catalog
THOC5: a novel gene involved in HDL-cholesterol metabolism.
NHGRI GWA Catalog
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • THC complex, organism-specific biosystem (from KEGG)
    THC complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • THC complex, conserved biosystem (from KEGG)
    THC complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • TREX complex, organism-specific biosystem (from KEGG)
    TREX complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • TREX complex, conserved biosystem (from KEGG)
    TREX complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
blastocyst development IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-templated transcription, elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
primitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of stem cell division IEA
Inferred from Electronic Annotation
more info
 
stem cell division IEA
Inferred from Electronic Annotation
more info
 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
THO complex IDA
Inferred from Direct Assay
more info
PubMed 
THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
THO complex subunit 5 homolog
Names
THO complex subunit 5 homolog
Fms-interacting protein
NF2/meningioma region protein pK1.3
PP39.2
functional spliceosome-associated protein 79
hTREX90
placental protein 39.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002877.1NP_001002877.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002877.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BX381026, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/TrEMBL
    A0A024R1D6
    UniProtKB/Swiss-Prot
    Q13769
    Related
    ENSP00000380971, OTTHUMP00000199692, ENST00000397873, OTTHUMT00000322100
    Conserved Domains (2) summary
    pfam09766
    Location:96453
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)
  2. NM_001002878.1NP_001002878.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BX400943, BX404329, CN387648, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/TrEMBL
    A0A024R1D6
    UniProtKB/Swiss-Prot
    Q13769
    Related
    ENSP00000380970, ENST00000397872
    Conserved Domains (2) summary
    pfam09766
    Location:96453
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)
  3. NM_001002879.1NP_001002879.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BU187531, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/TrEMBL
    A0A024R1D6
    UniProtKB/Swiss-Prot
    Q13769
    Related
    ENSP00000380969, ENST00000397871
    Conserved Domains (2) summary
    pfam09766
    Location:96453
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)
  4. NM_003678.4NP_003669.4  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_003669.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/TrEMBL
    A0A024R1D6
    UniProtKB/Swiss-Prot
    Q13769
    Conserved Domains (2) summary
    pfam09766
    Location:96453
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    29508167..29553760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261797.1XP_005261854.1  

    See identical proteins and their annotated locations for XP_005261854.1

    Conserved Domains (2) summary
    pfam09766
    Location:96464
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)
  2. XM_005261798.1XP_005261855.1  

    See identical proteins and their annotated locations for XP_005261855.1

    Conserved Domains (2) summary
    pfam09766
    Location:96464
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)
  3. XM_005261799.1XP_005261856.1  

    See identical proteins and their annotated locations for XP_005261856.1

    Conserved Domains (2) summary
    pfam09766
    Location:96464
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)
  4. XM_006724347.1XP_006724410.1  

    See identical proteins and their annotated locations for XP_006724410.1

    Conserved Domains (2) summary
    pfam09766
    Location:96464
    FimP; Fms-interacting protein
    pfam15112
    Location:89245
    DUF4559; Domain of unknown function (DUF4559)
  5. XM_005261801.2XP_005261858.1  

    Conserved Domains (1) summary
    pfam09766
    Location:1114
    FimP; Fms-interacting protein

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    29863485..29909025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)