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    SGV1 Sgv1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 856290, updated on 21-Jan-2012
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    Summary

    Gene symbol
    SGV1
    Gene description
    Sgv1p
    Primary source
    SGD:S000006365
    Locus tag
    YPR161C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BUR1
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    Genomic context

    Sequence :
    Chromosome: XVI; NC_001148.4 (864449..866422, complement)
    See SGV1 in MapViewer

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene tRNA Neighboring gene Gph1p Neighboring gene Orc4p Neighboring gene Tif3p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation. Stevens JR, et al. PLoS One, 2011. PMID 22022426.
    2. Tension directly stabilizes reconstituted kinetochore-microtubule attachments. Akiyoshi B, et al. Nature, 2010 Nov 25. PMID 21107429.
    3. The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress. Clausing E, et al. J Biol Chem, 2010 Dec 31. PMID 21075850.
    4. Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Brooks MA, et al. Structure, 2010 Sep 8. PMID 20826334.
    5. Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. García A, et al. Mol Cell Biol, 2010 Nov. PMID 20823273.

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Bur1-Bur2 interacts with RPA and maintains genome integrity during DNA replication stress
      Title: The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress.
    2. Data show that Bur1 phosphorylates the Spt5 C-terminal repeat domain (CTD) both in vivo and in isolated elongation complexes in vitro.
      Title: Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.
    3. Spt5 C-terminal domain is a substrate of BUR kinase and a platform for the association of proteins that promote both transcription elongation and histone modification in transcribed regions
      Title: Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.
    4. The findings provide evidence that histone modifications at the 5' and 3' ends of coding regions are regulated by distinct mechanisms and reveal that the Bur1-Bur2 and Paf1 complexes repress cryptic transcription through a Set2-independent pathway.
      Title: Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes.
    5. the interactions linking Cak1 with the PAF1 complex and with Ssu72 are not direct but mediated via Ctk1 and Bur1
      Title: Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1.
    6. In vivo identified substrates for Bur1 link its role to transcriptional elongation and demonstrate a potential activation mechanism for histone H2B monoubiquitination by the Rad6/Bre1 complex.
      Title: The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS.
    7. SGV1 is required for the normal pattern of histone methylation by SET2.
      Title: The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_015487.1 NC_001134.7 GAL1    BIND  PubMed Bur1 interacts with GAL1. 
    NP_015487.1 NC_001134.7     BIND  PubMed Bur1 interacts with GAl1/10 UAS. 
    BioGRID:36334 BioGRID:35247 ABF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33625 AIM23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34596 BFR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32351 BFR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35876 BRE5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34325 BRX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36344 BSP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35231 BUB2    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:34429 BUB3    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:30969 BUD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31493 BUR2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Dosage Rescue; Phenotypic Suppression; Synthetic Growth Defect; Two-hybrid 
    BioGRID:36334 BioGRID:31117 CAK1    BioGRID  PubMed Dosage Rescue; Synthetic Growth Defect 
    BioGRID:36334 BioGRID:31446 CBF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35210 CCS1    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:36917 CHD1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:35376 CIK1    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:31725 CLN3    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:31688 CRN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36302 CTF4    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:36625 CTF8    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:33997 CTK1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36334 BioGRID:34272 CTR9    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36334 BioGRID:31544 DBP9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35002 DSN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33205 DST1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:32415 EAF1    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:36200 EAF3    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:33966 EBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33773 ESS1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:35456 FCP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:30970 GBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32265 GCD6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33062 GCN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36828 GET2    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:36430 GPA1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:33727 HCA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:36334 BioGRID:36054 HHO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32711 HHT1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:35796 HHT2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:32227 HMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35821 HRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32775 HSP26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32699 HTA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32700 HTB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35111 IMD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34838 IMP2'    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35718 INP52    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33080 KEM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35531 KRI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31149 LOC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36554 LSM12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36173 LSP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32836 MEC1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:33900 MGM101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35208 MIH1    BioGRID  PubMed Biochemical Activity 
    BioGRID:36334 BioGRID:32296 MNN10    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:36811 MOT2    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36334 BioGRID:30926 MRC1    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:36334 BioGRID:36227 NHP6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32040 NOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34361 NOP12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31913 NOP14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36037 NOP53    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32489 NPL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36736 NUG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33102 NUT1    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:32973 PAF1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36334 BioGRID:32542 PKH1    BioGRID  PubMed Positive Genetic 
    BioGRID:36334 BioGRID:34897 PRK1    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:36334 BioGRID:31466 PWP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35137 RAD52    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:36334 BioGRID:33189 RAD6    BioGRID  PubMed Biochemical Activity 
    BioGRID:36334 BioGRID:31793 RFA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Rescue 
    BioGRID:36334 BioGRID:35527 RFA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31012 RIM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35591 RPA49    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34547 RPB2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:35712 RPC19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34212 RPF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31349 RPL10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31921 RPO21    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Synthetic Growth Defect 
    BioGRID:36334 BioGRID:36875 RPS26B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32887 RPS9B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35407 RRP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34682 RRS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36869 RSP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:30988 RVS161    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32449 RVS167    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35235 SAM37    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:34161 SAP190    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31910 SAS10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:36388 SBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33461 SER2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:36334 BioGRID:33591 SET2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:34992 SGN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35368 SGS1    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:32566 SLF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:34886 SLM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35109 SML1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:30932 SPB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32412 SPC110    BioGRID  PubMed Co-purification 
    BioGRID:36334 BioGRID:33049 SPT16    BioGRID  PubMed Dosage Rescue; Synthetic Lethality 
    BioGRID:36334 BioGRID:33308 SPT4    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:36334 BioGRID:35159 SPT5    BioGRID  PubMed Biochemical Activity; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:36334 BioGRID:33361 SPT6    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:35627 SSB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33797 SSC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35614 SSU72    BioGRID  PubMed Synthetic Rescue 
    BioGRID:36334 BioGRID:31419 STM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35302 STO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:35211 SUB1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:34489 TMA46    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32173 TMA64    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31998 TSR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32428 XRS2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36334 BioGRID:31796 YAR010C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:31907 YDL156W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:33255 YGR012W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36334 BioGRID:32506 YHP1    BioGRID  PubMed Negative Genetic 
    BioGRID:36334 BioGRID:31469 YKE2    BioGRID  PubMed Negative Genetic 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II carboxy-terminal domain kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    RNA polymerase II carboxy-terminal domain kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphorylation of RNA polymerase II C-terminal domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphorylation of RNA polymerase II C-terminal domain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    phosphorylation of RNA polymerase II C-terminal domain IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    positive regulation of histone H3-K4 methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription, DNA-dependent IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
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    General protein information

    Names
    Sgv1p
    NP_015487.1
    • Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4

      Range
      864449..866422, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184258.1 → NP_015487.1  Sgv1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P23293
      Conserved Domains (2) summary
      cd07866
      Location:50 – 366
      Blast Score: 1438
      STKc_BUR1; Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Bypass UAS Requirement 1 and similar proteins.
      pfam00069
      Location:60 – 366
      Blast Score: 751
      Pkinase; Protein kinase domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006949.2 DAA11578.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P23293.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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