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TKL1 transketolase TKL1 [ Saccharomyces cerevisiae S288c ]

Gene ID: 856188, updated on 12-Apr-2014
Gene symbol
TKL1
Gene description
transketolase TKL1
Primary source
SGD:S000006278
Locus tag
YPR074C
Gene type
protein coding
RNA name
transketolase TKL1
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Location :
chromosome: XVI
Sequence :
Chromosome: XVI; NC_001148.4 (692796..694838, complement)
See TKL1 in MapViewer

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core subunit NOT5 Neighboring gene Ltp1p Neighboring gene Opy2p Neighboring gene hypothetical protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transketolase activity IEA
Inferred from Electronic Annotation
more info
 
transketolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transketolase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
metabolic process IEA
Inferred from Electronic Annotation
more info
 
pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
PubMed 
pentose-phosphate shunt TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Names
transketolase TKL1
NP_015399.1
  • Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4

    Range
    692796..694838, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184171.1NP_015399.1  transketolase TKL1 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_015399.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P23254
    Conserved Domains (4) summary
    cd07033
    Location:360528
    Blast Score: 495
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    TIGR00232
    Location:9664
    Blast Score: 2967
    tktlase_bact; transketolase, bacterial and yeast
    cd02012
    Location:14276
    Blast Score: 1055
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:546656
    Blast Score: 216
    Transketolase_C; Transketolase, C-terminal domain

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