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ERV2 flavin-linked sulfhydryl oxidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856152, updated on 4-Feb-2024

Summary

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Gene symbol
ERV2
Gene description
flavin-linked sulfhydryl oxidase
Primary source
SGD:S000006241
Locus tag
YPR037C
See related
AllianceGenome:SGD:S000006241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables flavin-linked sulfhydryl oxidase activity. Involved in regulation of protein folding in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ERV2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (646448..647038, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit H Neighboring gene Spo24p Neighboring gene Irc16p Neighboring gene Tip41p Neighboring gene translation initiation factor eIF5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase. Wang W, et al. Biochemistry, 2007 Mar 20. PMID 17298084, Free PMC Article
  2. A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p. Gross E, et al. Nat Struct Biol, 2002 Jan. PMID 11740506
  3. Flavin-linked Erv-family sulfhydryl oxidases release superoxide anion during catalytic turnover. Daithankar VN, et al. Biochemistry, 2012 Jan 10. PMID 22148553, Free PMC Article
  4. Identification and characterisation of eroA and ervA, encoding two putative thiol oxidases from Aspergillus niger. Harvey AR, et al. Gene, 2010 Aug 1. PMID 20438816
  5. Structural determinants of substrate access to the disulfide oxidase Erv2p. Vala A, et al. J Mol Biol, 2005 Dec 9. PMID 16288914

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin-dependent sulfhydryl oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiol oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiol oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of protein folding in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
flavin-linked sulfhydryl oxidase
NP_015362.1
  • Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    646448..647038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184134.1 → NP_015362.1  TPA: flavin-linked sulfhydryl oxidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015362.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W448, Q12284
    UniProtKB/TrEMBL
    A0A6A5Q7A7, A6ZWT1, B3LL99, B5VTJ5, C7GQA0, C8ZJ62, G2WPL6, N1NW13
    Conserved Domains (1) summary
    COG5054
    Location:1 → 180
    ERV1; Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12284.1

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