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TFC8 transcription factor TFIIIC subunit TFC8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856100, updated on 13-Apr-2024

Summary

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Gene symbol
TFC8
Gene description
transcription factor TFIIIC subunit TFC8
Primary source
SGD:S000005928
Locus tag
YPL007C
See related
AllianceGenome:SGD:S000005928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA binding activity, bending; RNA polymerase III type 1 promoter sequence-specific DNA binding activity; and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (542082..543848, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rqc2p Neighboring gene DNA helicase Neighboring gene sphingolipid transporter Neighboring gene Aep3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly. Mylona A, et al. Mol Cell, 2006 Oct 20. PMID 17052456
  2. Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC. Mylona A, et al. Protein Expr Purif, 2006 Feb. PMID 16115780
  3. The two DNA-binding domains of yeast transcription factor tau as observed by scanning transmission electron microscopy. Schultz P, et al. EMBO J, 1989 Dec 1. PMID 2684647, Free PMC Article
  4. A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein. Deprez E, et al. Mol Cell Biol, 1999 Dec. PMID 10567530, Free PMC Article
  5. On the subunit composition, stoichiometry, and phosphorylation of the yeast transcription factor TFIIIC/tau. Conesa C, et al. J Biol Chem, 1993 Aug 25. PMID 7688737

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor TFIIIC subunit TFC8
NP_015318.1
  • Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    542082..543848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183821.1 → NP_015318.1  TPA: transcription factor TFIIIC subunit TFC8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015318.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W405, Q12308
    UniProtKB/TrEMBL
    A0A8H4F9U3, A6ZWN9, B3LL55, B5VTF5, C7GV51, C8ZJ19, N1NXE3
    Conserved Domains (2) summary
    sd00039
    Location:88 → 122
    7WD40; WD40 repeat [structural motif]
    pfam12660
    Location:515 → 585
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12308.1

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