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    NOP53 Nop53p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855957, updated on 5-Feb-2012
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    Summary

    Gene symbol
    NOP53
    Gene description
    Nop53p
    Primary source
    SGD:S000006067
    Locus tag
    YPL146C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: XVI; NC_001148.4 (276162..277529, complement)
    See NOP53 in MapViewer

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ppt2p Neighboring gene Pxa1p Neighboring gene Kes1p Neighboring gene Poc4p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S pre-rRNA processing. Sahasranaman A, et al. EMBO J, 2011 Sep 16. PMID 21926967.
    2. Dynamics of the putative RNA helicase Spb4 during ribosome assembly in Saccharomyces cerevisiae. García-Gómez JJ, et al. Mol Cell Biol, 2011 Oct. PMID 21825077.
    3. Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells. Schwer B, et al. Nucleic Acids Res, 2011 Aug. PMID 21558325.
    4. Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Fasolo J, et al. Genes Dev, 2011 Apr 1. PMID 21460040.
    5. Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Scherrer T, et al. Genome Biol, 2011. PMID 21232131.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. protein A-tagged Nop53p coprecipitated the 27S and 7S pre-rRNAs, and His-Nop53p also bound directly 5.8S rRNA in vitro, which is consistent with a role for Nop53p in pre-rRNA processing
      Title: Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae.
    2. Nop53p is a late-acting factor in the nuclear maturation of 60S ribosomal subunits, which is required for normal acquisition of export competence.
      Title: Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast.
    3. Deletion or mutations within NOP53 cause significant growth defects and display significant 60 S subunit deficiencies, an imbalance in the 40 S:60 S ratio, and defects in progression beyond the 27 S stage of 25 S rRNA maturation during 60 S biogenesis.
      Title: Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:36037 BioGRID:33634 ALB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:32159 ARX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34456 ASE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:33074 ATG1    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:36005 CBC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:31446 CBF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:36484 CIC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:31166 CMK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:32207 CPR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:36348 DPB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:33966 EBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:32422 ESF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:35067 FPR3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:31707 FPR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:32682 FUS3    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:36037 BioGRID:35364 HSC82    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34044 MIF2    BioGRID  PubMed Two-hybrid 
    BioGRID:36037 BioGRID:33705 MTR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:35974 NIP7    BioGRID  PubMed Two-hybrid 
    BioGRID:36037 BioGRID:36088 NOG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:35715 NOP15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:35762 NOP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34698 NOP58    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:36037 BioGRID:31957 NSE4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:36736 NUG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:35221 NUP116    BioGRID  PubMed Co-purification 
    BioGRID:36037 BioGRID:31777 OAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:35101 ORC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34285 PAP2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:36037 BioGRID:36147 PHO85    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:36465 PIH1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:36037 BioGRID:33131 PRP43    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:32026 PRP9    BioGRID  PubMed Two-hybrid 
    BioGRID:36037 BioGRID:36155 RAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34515 RIO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:36037 BioGRID:36631 RIX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34212 RPF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34462 RPL3    BioGRID  PubMed Co-fractionation 
    BioGRID:36037 BioGRID:33573 RPS22A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:35728 RPS7B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:34011 RRN3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:36037 BioGRID:32472 RRP17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:31018 RRP43    BioGRID  PubMed Reconstituted Complex 
    BioGRID:36037 BioGRID:34404 RRP6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:36037 BioGRID:36869 RSP5    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:31739 SAW1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:33496 SDA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:36334 SGV1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:32529 SNF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:31147 SPB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:31419 STM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:33595 TPK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:33971 TPK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:31998 TSR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:31693 TSR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:33333 UTP22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36037 BioGRID:36568 YCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:35675 YCK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:36037 BioGRID:31025 YCR043C    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Homology

    • Homologs of the NOP53 gene: The NOP53 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice.

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Nop53p
    NP_015179.1
    • Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4

      Range
      276162..277529, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183960.1 → NP_015179.1  Nop53p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q12080
      Conserved Domains (1) summary
      pfam07767
      Location:17 – 268
      Blast Score: 292
      Nop53; Nop53 (60S ribosomal biogenesis)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006949.2 DAA11289.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q12080.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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