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PPT2 holo-[acyl-carrier-protein] synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855955, updated on 13-Apr-2024

Summary

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Gene symbol
PPT2
Gene description
holo-[acyl-carrier-protein] synthase
Primary source
SGD:S000006069
Locus tag
YPL148C
See related
AllianceGenome:SGD:S000006069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables holo-[acyl-carrier-protein] synthase activity. Involved in holo-[acyl-carrier-protein] biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (272294..272815, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Atg5p Neighboring gene ATP-binding cassette long-chain fatty acid transporter PXA1 Neighboring gene Nop53p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein. Stuible HP, et al. J Biol Chem, 1998 Aug 28. PMID 9712852
  2. The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis. Van Vranken JG, et al. Elife, 2016 Aug 19. PMID 27540631, Free PMC Article
  3. Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Qin T, et al. Nucleic Acids Res, 2014 Oct. PMID 25063300, Free PMC Article
  4. Synthetic negative genome screen of the GPN-loop GTPase NPA3 in Saccharomyces cerevisiae. Mora-García M, et al. Curr Genet, 2022 Aug. PMID 35660944
  5. Mitochondrial ER contacts are crucial for mitophagy in yeast. Böckler S, et al. Dev Cell, 2014 Feb 24. PMID 24530295

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables holo-[acyl-carrier-protein] synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables holo-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in holo-[acyl-carrier-protein] biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
holo-[acyl-carrier-protein] synthase
NP_015177.2
  • Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    272294..272815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183962.1 → NP_015177.2  TPA: holo-[acyl-carrier-protein] synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015177.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3M1, Q12036
    UniProtKB/TrEMBL
    A0A8H4BTQ1, A6ZWA6, B3LKT0, C7GJ99, G2WP35
    Conserved Domains (1) summary
    COG0736
    Location:12 → 173
    AcpS; Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12036.2

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