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    REV3 Rev3p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855936, updated on 6-Feb-2012
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    Summary

    Gene symbol
    REV3
    Gene description
    Rev3p
    Primary source
    SGD:S000006088
    Locus tag
    YPL167C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PSO1
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    Genomic context

    Sequence :
    Chromosome: XVI; NC_001148.4 (232593..237107, complement)
    See REV3 in MapViewer

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mex67p Neighboring gene hypothetical protein Neighboring gene Atg29p Neighboring gene Set6p Neighboring gene Mlh3p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA. Saugar I, et al. Nucleic Acids Res, 2012 Jan. PMID 21911365.
    2. Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. Boettner DR, et al. Mol Biol Cell, 2011 Oct. PMID 21849475.
    3. 3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro. Monti P, et al. DNA Repair (Amst), 2011 Aug 15. PMID 21676659.
    4. Lesion bypass by S. cerevisiae Pol ζ alone. Stone JE, et al. DNA Repair (Amst), 2011 Aug 15. PMID 21622032.
    5. Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast. Gangavarapu V, et al. MBio, 2011. PMID 21586645.

    See all (92) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. in addition to extending aberrant termini created by other DNA polymerases, Pol zeta has the potential to be the sole DNA polymerase involved in translesion synthesis
      Title: Lesion bypass by S. cerevisiae Pol ζ alone.
    2. Results imply that about 30% of starvation-associated base substitutions and frameshifts arise by some unknown mechanism that does not involve Pol zeta or NHEJ.
      Title: Evaluation of the roles of Pol zeta and NHEJ in starvation-associated spontaneous mutagenesis in the yeast Saccharomyces cerevisiae.
    3. The L979F Pol zeta, and perhaps wild-type Pol zeta, which also generates clustered mutations at a lower but significant rate, performs short patches of processive, error-prone DNA synthesis.
      Title: Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta.
    4. mismatch repair system promotes Polzeta-dependent mutagenesis by inhibiting an alternative, error-free pathway that depends on homologous recombination
      Title: The mismatch repair system promotes DNA polymerase zeta-dependent translesion synthesis in yeast.
    5. a specific subset of the Pol zeta-dependent mutational events requires oxidative metabolism
      Title: The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae.
    6. Strains deficient in Pol zeta (Rev3) show little bypass of the T-T (6-4) photoadduct or the abasic sites.
      Title: The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer.
    7. RAD6 and its epistasis group members have roles in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae
      Title: Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae.
    8. Physical association of Rev1 with DNA polymerase zeta is mediated through the carboxyl terminus of Rev1 and the polymerase domain of Rev3.
      Title: Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions.
    9. error-prone REV3 pathway determines spontaneous mutagenesis in Saccharomyces cerevisiae
      Title: Error-free RAD52 pathway and error-prone REV3 pathway determines spontaneous mutagenesis in Saccharomyces cerevisiae.
    10. DNA polymerase zeta and Rev1 proteins function in the mitochondria
      Title: Saccharomyces cerevisiae polymerase zeta functions in mitochondria.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:36016 BioGRID:32269 ADR1    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:34020 APN1    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression; Synthetic Growth Defect 
    BioGRID:36016 BioGRID:32679 APN2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:36930 BMH1    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:33440 BUB1    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:35041 CAC2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36016 BioGRID:32038 CDC7    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:33419 CLC1    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:34408 DNL4    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:32496 DOT1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:32972 DPB3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:32177 DPB4    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:32947 DUT1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:34435 EXO1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:36016 BioGRID:33503 GCN5    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:35909 HFI1    BioGRID  PubMed Positive Genetic 
    BioGRID:36016 BioGRID:32967 HSM3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:36891 MAG1    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:36016 BioGRID:34282 MCH4    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:34139 MEH1    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:36781 MEI4    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:35618 MGS1    BioGRID  PubMed Synthetic Lethality; Synthetic Rescue 
    BioGRID:36016 BioGRID:33163 MMS2    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:36016 BioGRID:34993 MPH1    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:36016 BioGRID:31751 NTG1    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression; Synthetic Growth Defect 
    BioGRID:36016 BioGRID:34359 NTG2    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression; Synthetic Growth Defect 
    BioGRID:36016 BioGRID:35721 POL1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:35577 POL2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:31960 POL3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:32794 POL30    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:36269 PRE2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:35314 PSO2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36016 BioGRID:31635 PSY3    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36016 BioGRID:36155 RAD1    BioGRID  PubMed Phenotypic Suppression; Synthetic Rescue 
    BioGRID:36016 BioGRID:35048 RAD10    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:36016 BioGRID:35379 RAD14    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:36016 BioGRID:34751 RAD17    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:31042 RAD18    BioGRID  PubMed Negative Genetic; Phenotypic Suppression; Synthetic Rescue 
    BioGRID:36016 BioGRID:36926 RAD24    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:36924 RAD3    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:32477 RAD30    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression; Synthetic Growth Defect 
    BioGRID:36016 BioGRID:36915 RAD4    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36016 BioGRID:31306 RAD5    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Lethality; Synthetic Rescue 
    BioGRID:36016 BioGRID:35589 RAD50    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:36841 RAD51    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:36016 BioGRID:35137 RAD52    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Phenotypic Suppression; Synthetic Growth Defect; Synthetic Lethality; Synthetic Rescue 
    BioGRID:36016 BioGRID:36030 RAD53    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:33090 RAD54    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:36016 BioGRID:32131 RAD55    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:36016 BioGRID:32057 RAD57    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:36016 BioGRID:33189 RAD6    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:36016 BioGRID:32270 RAD9    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:36016 BioGRID:34731 REV1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:36016 BioGRID:34852 REV7    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:36016 BioGRID:36395 RIM101    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:36588 RTT107    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:35927 RVB2    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:34437 SHE4    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:31352 SIC1    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:32469 SIZ1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:31404 SLX4    BioGRID  PubMed Phenotypic Suppression; Synthetic Growth Defect 
    BioGRID:36016 BioGRID:36861 SLX8    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:35109 SML1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:33665 SRS2    BioGRID  PubMed Phenotypic Suppression; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:36016 BioGRID:31786 SSA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36016 BioGRID:31229 SSA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36016 BioGRID:31882 SSB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36016 BioGRID:33524 TAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:36016 BioGRID:32199 TAF12    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:36052 TAF14    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:36016 BioGRID:35744 TPM1    BioGRID  PubMed Negative Genetic 
    BioGRID:36016 BioGRID:32149 UBC13    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement 
    BioGRID:36016 BioGRID:32873 UMP1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:31705 VMA6    BioGRID  PubMed Synthetic Lethality 
    BioGRID:36016 BioGRID:32428 XRS2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:36016 BioGRID:35464 YKU70    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:36016 BioGRID:35281 YKU80    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:36016 BioGRID:35952 YPL260W    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    error-free translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    error-prone translesion synthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with nuclear chromatin IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    zeta DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Rev3p
    NP_015158.1
    • Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4

      Range
      232593..237107, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183981.1 → NP_015158.1  Rev3p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P14284
      Conserved Domains (5) summary
      cd05778
      Location:664 – 892
      Blast Score: 813
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:919 – 1366
      Blast Score: 1954
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:12 – 221
      Blast Score: 183
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam00136
      Location:919 – 1366
      Blast Score: 881
      DNA_pol_B; DNA polymerase family B
      pfam14260
      Location:1398 – 1480
      Blast Score: 192
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006949.2 DAA11267.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P14284.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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