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MDL2 ATP-binding cassette permease MDL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855858, updated on 13-Apr-2024

Summary

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Gene symbol
MDL2
Gene description
ATP-binding cassette permease MDL2
Primary source
SGD:S000006191
Locus tag
YPL270W
See related
AllianceGenome:SGD:S000006191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ABC-type oligopeptide transporter activity. Involved in cellular response to hydrogen peroxide. Located in mitochondrial inner membrane. Colocalizes with vacuolar membrane. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MDL2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (30482..32803)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pbi1p Neighboring gene F1F0 ATP synthase subunit epsilon Neighboring gene Kar9p Neighboring gene phosphatidylinositol phospholipase C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily. Dean M, et al. Yeast, 1994 Mar. PMID 7912468
  2. Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters. Park K, et al. FEBS Lett, 2014 Sep 17. PMID 25128661
  3. Role of the ABC transporter Mdl1 in peptide export from mitochondria. Young L, et al. Science, 2001 Mar 16. PMID 11251115
  4. Proteome-wide signatures of function in highly diverged intrinsically disordered regions. Zarin T, et al. Elife, 2019 Jul 2. PMID 31264965, Free PMC Article
  5. Identification new potential multidrug resistance proteins of Saccharomyces cerevisiae. Grechko VM, et al. J Microbiol Methods, 2020 Sep. PMID 32795632

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modes of insertion into the mitochondrial membrane of individual segments of Mdl1 and Mdl2 differ and is dependent on domain sequence context.
    Title: Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ABC-type oligopeptide transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ABC-type oligopeptide transporter activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligopeptide export from mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligopeptide export from mitochondrion ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-binding cassette permease MDL2
NP_015053.2
  • Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    30482..32803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184084.1 → NP_015053.2  TPA: ATP-binding cassette permease MDL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015053.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3A0, P33311, Q08983
    UniProtKB/TrEMBL
    A0A6V8S377, A6ZVY6, B3LKG3, G2WNR6
    Conserved Domains (1) summary
    TIGR00958
    Location:1 → 685
    3a01208; Conjugate Transporter-2 (CT2) Family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33311.3

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