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    UBP10 Ubp10p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855535, updated on 31-Jan-2012
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    Summary

    Gene symbol
    UBP10
    Gene description
    Ubp10p
    Primary source
    SGD:S000005130
    Locus tag
    YNL186W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DOT4
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    Genomic context

    Sequence :
    Chromosome: XIV; NC_001146.8 (289498..291876)
    See UBP10 in MapViewer

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Kar1p Neighboring gene Swt21p Neighboring gene Mrpl19p Neighboring gene Npr1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Echtenkamp FJ, et al. Mol Cell, 2011 Jul 22. PMID 21777812.
    2. Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Fasolo J, et al. Genes Dev, 2011 Apr 1. PMID 21460040.
    3. Histone chaperone Chz1p regulates H2B ubiquitination and subtelomeric anti-silencing. Wan Y, et al. Nucleic Acids Res, 2010 Mar. PMID 20008511.
    4. Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Chandrasekharan MB, et al. Proc Natl Acad Sci U S A, 2009 Sep 29. PMID 19805358.
    5. Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation. Qin S, et al. Nucleic Acids Res, 2009 Apr. PMID 19188254.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_014213.1 NP_010510.1 HTB1    BIND  PubMed Ubp10 interacts with ubiquitinated H2B. 
    NP_014213.1 NC_001138.4     BIND  PubMed Ubp10 interacts with ChrVI-R telomere. 
    NP_014213.1 NC_001144.3     BIND  PubMed Ubp10 interacts with 5S rDNA. 
    NP_014213.1 NC_001144.3     BIND  PubMed Ubp10 interacts with 25S rDNA. 
    BioGRID:35647 BioGRID:33074 ATG1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:6258 ATL2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35647 BioGRID:33662 BCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:31446 CBF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:32859 CDC28    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:36765 CHZ1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35647 BioGRID:36484 CIC1    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:34460 CKA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:31166 CMK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:35713 DBP2    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:34054 DHR2    BioGRID  PubMed Affinity Capture-MS; PCA 
    BioGRID:35647 BioGRID:31398 DIP2    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:33952 DOA1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35647 BioGRID:33773 ESS1    BioGRID  PubMed Protein-peptide 
    BioGRID:35647 BioGRID:33297 FMP48    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:32682 FUS3    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:36524 GAR1    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:31159 GCN20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:33784 GEA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:35647 BioGRID:35364 HSC82    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:35923 HSP82    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:32276 HTB1    BioGRID  PubMed Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:35647 BioGRID:32700 HTB2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35647 BioGRID:33650 IME2    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:31369 KIN2    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:36517 KSP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:33287 KSS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:31149 LOC1    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:34595 MCA1    BioGRID  PubMed Dosage Lethality; Phenotypic Suppression 
    BioGRID:35647 BioGRID:35738 MKT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:32028 MPS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:32946 MRPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:34601 NOC2    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:31832 NOP6    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:36147 PHO85    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:33188 PKP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:36669 PRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:34897 PRK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:34120 PRP40    BioGRID  PubMed Protein-peptide 
    BioGRID:35647 BioGRID:33816 PTK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:36030 RAD53    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:33189 RAD6    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35647 BioGRID:33096 RCK1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:35647 BioGRID:35823 RLP7    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:35591 RPA49    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:30952 RRP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:36303 RRP9    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:31047 RSA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:34018 SBA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:35647 BioGRID:32420 SEM1    BioGRID  PubMed Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:35647 BioGRID:33591 SET2    BioGRID  PubMed Protein-peptide 
    BioGRID:35647 BioGRID:32279 SIR4    BioGRID  PubMed Affinity Capture-MS; Phenotypic Enhancement; Synthetic Rescue; Two-hybrid 
    BioGRID:35647 BioGRID:34287 SKM1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:35394 SKY1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:32529 SNF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:33965 SNU114    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:31240 SOF1    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:32573 SPS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:35647 BioGRID:33665 SRS2    BioGRID  PubMed Two-hybrid 
    BioGRID:35647 BioGRID:36137 SSN3    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:31419 STM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:33575 SWE1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:33075 TOS3    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:33595 TPK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:35647 UBP10    BioGRID  PubMed PCA 
    BioGRID:35647 BioGRID:31160 UBP6    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35647 BioGRID:35401 UBP8    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35647 BioGRID:33333 UTP22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:31137 WWM1    BioGRID  PubMed Protein-peptide 
    BioGRID:35647 BioGRID:36568 YCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:35675 YCK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:35647 BioGRID:33502 YGR251W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35647 BioGRID:36033 YPL150W    BioGRID  PubMed Biochemical Activity 
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    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin thiolesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin silencing at telomere IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Ubp10p
    NP_014213.2
    • Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8

      Range
      289498..291876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183024.2 → NP_014213.2  Ubp10p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P53874
      Conserved Domains (2) summary
      cl02553
      Location:362 – 731
      Blast Score: 458
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam13423
      Location:363 – 708
      Blast Score: 94
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006947.3 DAA10367.2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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