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    CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 8555, updated on 11-May-2012

    Summary

    Official Symbol
    CDC14Bprovided by HGNC
    Official Full Name
    CDC14 cell division cycle 14 homolog B (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:1719
    Locus tag
    RP11-172F4.1
    See related
    Ensembl:ENSG00000081377; HPRD:04615; MIM:603505; Vega:OTTHUMG00000020300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
    Summary
    The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    9q22.3
    Sequence :
    Chromosome: 9; NC_000009.11 (99262395..99382112, complement)
    See CDC14B in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog (S. cerevisiae) pseudogene Neighboring gene zinc finger protein 367 Neighboring gene hyaluronan binding protein 4 Neighboring gene uncharacterized LOC100507364 Neighboring gene AhpC/TSA antioxidant enzyme domain containing 1 Neighboring gene makorin ring finger protein 1 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O60729 Q8IXJ6 SIRT2    HPRD  PubMed  
    O60729 P04637 TP53    HPRD  PubMed  
    BioGRID:114125 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114125 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    G2/M transition DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of anaphase-promoting complex activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity protein phosphatase CDC14B
    Names
    dual specificity protein phosphatase CDC14B
    NP_001070649.1
    NP_003662.1
    NP_201588.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077181.1NP_001070649.1  dual specificity protein phosphatase CDC14B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 2, resulting in a protein (isoform 3) that has an alternate N-terminus, compared to isoform 2.
      Source sequence(s)
      AK126388, AL133477, DA943563
      Consensus CDS
      CCDS43853.1
      Related
      ENSP00000364390, OTTHUMP00000215877, ENST00000375242, OTTHUMT00000356340
      Conserved Domains (1) summary
      cl00053
      Location:216323
      Blast Score: 146
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_003671.3NP_003662.1  dual specificity protein phosphatase CDC14B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment in the C-terminal region, compared to isoform 2.
      Source sequence(s)
      AF064104, AL133477
      Consensus CDS
      CCDS6721.1
      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000364388, OTTHUMP00000021730, ENST00000375240, OTTHUMT00000053279
      Conserved Domains (1) summary
      cl00053
      Location:253360
      Blast Score: 146
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_033331.2NP_201588.1  dual specificity protein phosphatase CDC14B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AF064104, AL133477
      Consensus CDS
      CCDS6722.1
      UniProtKB/Swiss-Prot
      O60729
      Related
      ENSP00000364389, OTTHUMP00000021729, ENST00000375241, OTTHUMT00000053278
      Conserved Domains (1) summary
      cl00053
      Location:253360
      Blast Score: 147
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      99262395..99382112, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      68873293..68940865, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033332.1: Suppressed sequence

      Description
      NM_033332.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL133477.16 CAI39616.1
      CAI39617.1
      CAI39619.1
    genomic AL353578.18 CAI40536.1
      CAI40537.1
      CAI40540.1
      CAI40541.1
    genomic AY675321.1 AAT70726.1
    genomic CH471174.1 EAW92658.1
      EAW92659.1
    mRNA AF023158.1 AAB88293.1
    mRNA AF064104.1 AAC16661.1
    mRNA AF064105.2 AAC16662.2
    mRNA AK126388.1 BAG54321.1
    mRNA AK225361.1 None
    mRNA BC050013.1 None
    mRNA DA943563.1 None
    mRNA EF611343.1 ABR12627.1
    other-genetic BC156666.1 AAI56667.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60729.1 GenPept UniProtKB/Swiss-Prot:O60729
    Q5JU06 GenPept UniProtKB/TrEMBL:Q5JU06

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