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    SSU72 Ssu72p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855499, updated on 6-May-2012
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    Summary

    Gene symbol
    SSU72
    Gene description
    Ssu72p
    Primary source
    SGD:S000005166
    Locus tag
    YNL222W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: XIV
    Sequence :
    Chromosome: XIV; NC_001146.8 (229094..229714)
    See SSU72 in MapViewer

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sqs1p Neighboring gene Atg4p Neighboring gene ncRNA Neighboring gene Pop1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination. Zhang DW, et al. J Biol Chem, 2012 Mar 9. PMID 22235117.
    2. The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Ghazy MA, et al. Nucleic Acids Res, 2012 Feb. PMID 21993299.
    3. A flexible linker region in Fip1 is needed for efficient mRNA polyadenylation. Ezeokonkwo C, et al. RNA, 2011 Apr. PMID 21282348.
    4. A global protein kinase and phosphatase interaction network in yeast. Breitkreutz A, et al. Science, 2010 May 21. PMID 20489023.
    5. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.

    See all (39) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.
      Title: Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.
    2. the interactions linking Cak1 with the PAF1 complex and with Ssu72 are not direct but mediated via Ctk1 and Bur1
      Title: Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1.
    3. Ssu72 catalyzes serine-5-P dephosphorylation subsequent to addition of the 7-methylguanosine cap on pre-mRNA in a manner that facilitates the RNAP II transition into the elongation stage of the transcription cycle.
      Title: Role for the Ssu72 C-terminal domain phosphatase in RNA polymerase II transcription elongation.
    4. The mechanisms of reading the CTD code by two classes of protein phosphatases, plant CPLs and yeast Ssu72, that specifically dephosphorylate Ser(5) in vitro are reported.
      Title: Different strategies for carboxyl-terminal domain (CTD) recognition by serine 5-specific CTD phosphatases.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_014177.1 NP_013216.1 CFT2    BIND  PubMed Cft2 (Ydh1) interacts with Ssu72. 
    NP_014177.1 NP_009356.1 PTA1    BIND  PubMed Ssu72 interacts with Pta1. 
    NP_014177.1 NP_011672.1 PTI1    BIND  PubMed Pti1 interacts with Ssu72 as part of the APT complex. 
    NP_014177.1 NP_014794.1 RPB2    BIND  PubMed Ssu72 interacts with Rpb2. 
    NP_014177.1 NP_015411.1 SUA7    BIND  PubMed Sua7 (TFIIB) interacts with Ssu72. 
    NP_014177.1     BIND  PubMed Ssu72 dephosphorylates RNAPII on its Serine 5 of the CTD repeats of its Rpb1 subunit. This interaction was modeled on a demonstrated interaction between Yeast Rpb1 and Ssu72 from an unspecified species. 
    BioGRID:35614 BioGRID:31107 ACT1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35614 BioGRID:31362 ALT1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32183 ARO1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31358 ARP6    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:35292 ASC1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36357 ATG13    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32625 ATG8    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36749 BIM1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35614 BioGRID:36930 BMH1    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:35569 BNI1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:35614 BioGRID:31987 BRE1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31289 BRE2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31121 BST1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36110 BTS1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31123 BUD27    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31117 CAK1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35614 BioGRID:36540 CDC12    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35614 BioGRID:32859 CDC28    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35614 BioGRID:33066 CDC55    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:32353 CFT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:31387 CFT2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:35614 BioGRID:36169 CHL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:35376 CIK1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34441 CKB2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34640 CLP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:35614 BioGRID:35867 COQ2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36011 COX10    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:35434 COX7    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36302 CTF4    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:33997 CTK1    BioGRID  PubMed Negative Genetic; Synthetic Rescue 
    BioGRID:35614 BioGRID:35467 DSS1    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:31791 ERP1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33193 ERV14    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33773 ESS1    BioGRID  PubMed Dosage Rescue; Synthetic Growth Defect 
    BioGRID:35614 BioGRID:35456 FCP1    BioGRID  PubMed Dosage Rescue 
    BioGRID:35614 BioGRID:33847 FIP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35614 BioGRID:36491 FYV4    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:36877 GLC7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:32209 HOM2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33063 HOS2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34392 HTZ1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36272 ISR1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36310 KAR3    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:33080 KEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31954 KIN28    BioGRID  PubMed Affinity Capture-Western; Synthetic Lethality 
    BioGRID:35614 BioGRID:35972 LEA1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34518 LEO1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36125 LGE1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36516 LRP1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34373 MDM38    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34863 MET18    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34337 MET22    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33830 MOG1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34074 MPE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:32795 NHP6B    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36511 NMD2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35614 BioGRID:32040 NOP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:35614 BioGRID:33290 NQM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:36403 OPI1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34645 OSW1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34134 PAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:32280 PCF11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:35614 BioGRID:36903 PET122    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32868 PEX32    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33492 PFK1    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:35522 PFS2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:35614 BioGRID:33483 PHB2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36143 PMA2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:35856 PPG1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31784 PTA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Dosage Lethality; Reconstituted Complex; Two-hybrid 
    BioGRID:35614 BioGRID:33404 PTI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:32253 RAV2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32247 REF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:31631 ROM2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34547 RPB2    BioGRID  PubMed Reconstituted Complex; Synthetic Rescue; Two-hybrid 
    BioGRID:35614 BioGRID:31921 RPO21    BioGRID  PubMed Protein-peptide; Synthetic Rescue 
    BioGRID:35614 BioGRID:31978 RPS16B    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31619 RSC2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32996 RTF1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32342 RTT103    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32801 RXT2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34161 SAP190    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:35441 SAP30    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32522 SDC1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34908 SDS3    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33006 SEC15    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35614 BioGRID:32782 SEC18    BioGRID  PubMed Synthetic Lethality 
    BioGRID:35614 BioGRID:32221 SEC7    BioGRID  PubMed Synthetic Lethality 
    BioGRID:35614 BioGRID:34162 SET3    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36334 SGV1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35614 BioGRID:32807 SIF2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32024 SLM3    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:36861 SLX8    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:33323 SLX9    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33136 SNF4    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33124 SOH1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32454 SPT3    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:33308 SPT4    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35614 BioGRID:31330 SPT8    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36473 SRB2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36210 SRO7    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31710 SST2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:30951 STE50    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36257 SUA7    BioGRID  PubMed Affinity Capture-Western; Dosage Rescue; Phenotypic Enhancement; Reconstituted Complex; Synthetic Lethality; Synthetic Rescue 
    BioGRID:35614 BioGRID:35211 SUB1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32363 SUM1    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:31755 SWC3    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32926 SWC5    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34114 SWD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:32391 SWR1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34574 SYC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:31024 TAF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:35586 TEX1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31033 THR4    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32166 TRS85    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:35128 VPS71    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:32537 VPS72    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31601 VRP1    BioGRID  PubMed Positive Genetic 
    BioGRID:35614 BioGRID:34444 WHI2    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:30976 YCL002C    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36906 YER156C    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36546 YHR113W    BioGRID  PubMed Two-hybrid 
    BioGRID:35614 BioGRID:34063 YKL069W    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31556 YLR290C    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:36201 YME1    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:34327 YOL075C    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31529 YPT6    BioGRID  PubMed Negative Genetic 
    BioGRID:35614 BioGRID:31545 YSH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35614 BioGRID:36273 YTH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35614 BioGRID:35422 ZRC1    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    • Homologs of the SSU72 gene: The SSU72 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.

    Pathways from BioSystems

    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    contributes_to RNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoprotein phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    phosphoric ester hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    snoRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    termination of RNA polymerase II transcription, exosome-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    termination of RNA polymerase II transcription, exosome-dependent IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    termination of RNA polymerase II transcription, poly(A)-coupled IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    termination of RNA polymerase II transcription, poly(A)-coupled IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    mRNA cleavage and polyadenylation specificity factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
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    General protein information

    Names
    Ssu72p
    NP_014177.1
    • Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8

      Range
      229094..229714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183060.1 → NP_014177.1  Ssu72p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P53538
      Conserved Domains (1) summary
      cl02161
      Location:8 – 206
      Blast Score: 911
      Ssu72; Ssu72-like protein
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006947.3 DAA10334.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53538.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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