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RAD50 MRX complex DNA-binding subunit [ Saccharomyces cerevisiae S288c ]

Gene ID: 855471, updated on 13-Aug-2016
Gene symbol
RAD50
Gene description
MRX complex DNA-binding subunit
Primary source
SGD:S000005194
Locus tag
YNL250W
Gene type
protein coding
RNA name
MRX complex DNA-binding subunit
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See RAD50 in Map Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (175410..179348)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL17/YmL30 Neighboring gene Nrd1 complex RNA-binding subunit Neighboring gene Mpa43p Neighboring gene DNA-directed RNA polymerase I subunit RPA49

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
adenylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
double-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via break-induced replication TAS
Traceable Author Statement
more info
PubMed 
double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of DNA trinucleotide repeats IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic DNA double-strand break formation TAS
Traceable Author Statement
more info
PubMed 
meiotic DNA double-strand break processing TAS
Traceable Author Statement
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance via recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Mre11 complex IEA
Inferred from Electronic Annotation
more info
 
Mre11 complex IPI
Inferred from Physical Interaction
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
MRX complex DNA-binding subunit
NP_014149.1
  • Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    175410..179348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183088.1NP_014149.1  MRX complex DNA-binding subunit [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_014149.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12753
    Conserved Domains (3) summary
    TIGR00606
    Location:21302
    rad50; rad50
    cd03240
    Location:11981300
    ABC_Rad50; ATP-binding cassette domain of Rad50
    pfam04423
    Location:665719
    Rad50_zn_hook; Rad50 zinc hook motif