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    PIAS1 protein inhibitor of activated STAT, 1 [ Homo sapiens ]

    Gene ID: 8554, updated on 12-May-2012
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    Summary

    Official Symbol
    PIAS1provided by HGNC
    Official Full Name
    protein inhibitor of activated STAT, 1provided by HGNC
    Primary source
    HGNC:2752
    See related
    Ensembl:ENSG00000033800; HPRD:16029; MIM:603566; Vega:OTTHUMG00000172645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GBP; ZMIZ3; DDXBP1; GU/RH-II; MGC141878; MGC141879
    Summary
    This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    15q
    Sequence :
    Chromosome: 15; NC_000015.9 (68346572..68480413)
    See PIAS1 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene calmodulin-like 4 Neighboring gene ceroid-lipofuscinosis, neuronal 6, late infantile, variant

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Protein phosphatase 1α interacting proteins in the human brain. Esteves SL, et al. OMICS, 2012 Jan-Feb. PMID 22321011.
    2. The expression of protein inhibitor of activated signal transducers and activators of transcription 3 in the evolutionary process of gastric cancer. Liu LM, et al. Eur J Intern Med, 2011 Oct. PMID 21925039.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein independent of its SUMO ligase activity. Song YJ, et al. Mol Cells, 2011 Sep. PMID 21717107.
    5. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.

    See all (104) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein independent of its SUMO ligase activity.
      Title: PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein independent of its SUMO ligase activity.
    2. There are differences in the PIAS3 expression from different stages of gastric precancerous conditions/lesions to GC, which may reveal a close relationship between expression reduction or loss of PIAS3 and gastric tumorigenesis.
      Title: The expression of protein inhibitor of activated signal transducers and activators of transcription 3 in the evolutionary process of gastric cancer.
    3. PIAS1 determines the level of JNK activity in human endometrial stromal cells , couples ROS signaling to the SUMO pathway, and promotes oxidative cell death.
      Title: The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death.
    4. Ubc9 and PIAS1 potentiated SF-1-mediated transactivation of human CYP17, CYP11A1, and CYP11B1 but not CYP11B2 promoters.
      Title: Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1.
    5. PIAS1 is a common partner for two cancer-related nuclear factors, c-Myb and FLASH.
      Title: PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.
    6. FOXL2 interacts with PIAS1 and UBC9, and sumoylated in both human and mouse
      Title: The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.
    7. Pias1-dependent SUMOylation influences Gli protein activity
      Title: SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.
    8. Data show that regulation of SATB1 sumoylation and caspase cleavage is controlled by SATB1 phosphorylation; specifically, PIAS1 interaction with SATB1 is inhibited by phosphorylation.
      Title: Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
    10. PIAS1 staining of the colon cancer tissue microarrays indicated a strong correlation of normal colon cells, and adenomas, with high expression of both PIAS1 and IRF-1
      Title: Substantially reduced expression of PIAS1 is associated with colon cancer development.
    Submit: New GeneRIF Correction See all (33)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAC36702.1 NP_004355.2 CEBPA    BIND  PubMed C/EBP-alpha interacts with PIAS1. 
    AAC36702.1 AAC51130.1 CEBPE    BIND  PubMed C/EBP-epsilon interacts with PIAS1. 
    NP_057250.1 Q14790 CASP8    BIND  PubMed CASP8 (caspase-8) interacts with PIAS-1. 
    NP_057250.1 NP_001312.1 CSRP2    BIND  PubMed CRP2 interacts with PIAS1. 
    NP_057250.1 NP_000116.2 ESR1    BIND  PubMed ER-alpha interacts with PIAS1. 
    NP_057250.1 NP_941977.1 HTNVsSgp1    BIND  PubMed Hantaan virus nucleocapsid protein interacts with PIAS1. 
    NP_057250.1 NP_003343.1 SUMO1    BIND  PubMed SUMO-1 interacts with PIAS1. 
    NP_057250.1 NP_000537.2 TP53    BIND  PubMed PIAS1 interacts with p53. This interaction was modeled on a demonstrated interaction between human PIAS1 and p53 from an unspecified species. 
    NP_057250.1 NP_003336.1 UBE2I    BIND  PubMed Ubc9 interacts with PIAS1. 
    NP_057250.1 P17881     BIND  PubMed Seoul virus nucleocapsid protein interacts with PIAS1. 
    NP_057250.1     BIND  PubMed PIAS1 interacts with A/T-rich double-stranded DNA. 
    O75925 P10275 AR    HPRD  PubMed  
    O75925 O15169 AXIN1    HPRD  PubMed  
    O75925 Q14790 CASP8    HPRD  PubMed  
    O75925 P49715 CEBPA    HPRD  PubMed  
    O75925 Q15744 CEBPE    HPRD  PubMed  
    O75925 O15111 CHUK    HPRD  PubMed  
    O75925 Q92793 CREBBP    HPRD  PubMed  
    O75925 Q16527 CSRP2    HPRD  PubMed  
    O75925 Q6PJP8 DCLRE1A    HPRD  PubMed  
    O75925 Q9NR30 DDX21    HPRD  PubMed  
    O75925 Q05193 DNM1    HPRD  PubMed  
    O75925 Q9Y6K1 DNMT3A    HPRD  PubMed  
    O75925 P41970 ELK3    HPRD  PubMed  
    O75925 P03372 ESR1    HPRD  PubMed  
    O75925 Q92731 ESR2    HPRD  PubMed  
    O75925 P43694 GATA4    HPRD  PubMed  
    O75925 O00222 GRM8    HPRD  PubMed  
    O75925 P05412 JUN    HPRD  PubMed  
    O75925 Q9UIS9 MBD1    HPRD  PubMed  
    O75925 Q00987 MDM2    HPRD  PubMed  
    O75925 P28360 MSX1    HPRD  PubMed  
    O75925 Q8N4C6 NIN    HPRD  PubMed  
    O75925 P24468 NR2F2    HPRD  PubMed  
    O75925 P08235 NR3C2    HPRD  PubMed  
    O75925 Q13285 NR5A1    HPRD  PubMed  
    O75925 P06401 PGR    HPRD  PubMed  
    O75925 O75925 PIAS1    HPRD  PubMed  
    O75925 O75928 PIAS2    HPRD  PubMed  
    O75925 Q8N2W9 PIAS4    HPRD  PubMed  
    O75925 O75400 PRPF40A    HPRD  PubMed  
    O75925 Q05397 PTK2    HPRD  PubMed  
    O75925 P18031 PTPN1    HPRD  PubMed  
    O75925 Q04206 RELA    HPRD  PubMed  
    O75925 Q9UPW6 SATB2    HPRD  PubMed  
    O75925 SERPINE1 mRNA binding protein 1 SERBP1    HPRD  PubMed  
    O75925 P12757 SKIL    HPRD  PubMed  
    O75925 Q15797 SMAD1    HPRD  PubMed  
    O75925 Q13485 SMAD4    HPRD  PubMed  
    O75925 O15105 SMAD7    HPRD  PubMed  
    O75925 Q8TAD8 SNIP1    HPRD  PubMed  
    O75925 Q02447 SP3    HPRD  PubMed  
    O75925 P42224 STAT1    HPRD  PubMed  
    O75925 Q9UMX1 SUFU    HPRD  PubMed  
    O75925 P63165 SUMO1    HPRD  PubMed  
    O75925 P20226 TBP    HPRD  PubMed  
    O75925 P04637 TP53    HPRD  PubMed  
    O75925 O15350 TP73    HPRD  PubMed  
    O75925 P63279 UBE2I    HPRD  PubMed  
    O75925 P36508 ZNF76    HPRD  PubMed  
    BioGRID:114124 BioGRID:106710 AKT1    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:106862 AR    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:107140 BRCA1    BioGRID  PubMed Biochemical Activity; Co-localization 
    BioGRID:114124 BioGRID:107775 CREB1    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:107848 CSRP2    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:115263 DCLRE1A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114124 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114124 BioGRID:108125 DNMT3A    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:108126 DNMT3B    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:114124 BioGRID:108403 ESR1    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:109014 GLUL    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:109337 HIC1    BioGRID  PubMed Biochemical Activity 
    BioGRID:114124 BioGRID:109928 JUN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114124 BioGRID:115138 MAML1    BioGRID  PubMed Biochemical Activity 
    BioGRID:114124 BioGRID:110322 MBD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:110432 MITF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114124 BioGRID:110684 MX1    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114124 BioGRID:111464 PPARG    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:114124 BioGRID:111493 PPP1CA    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:111865 RBBP6    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:112201 SAFB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114124 BioGRID:112211 SATB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:112372 SIAH1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:112373 SIAH2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:112553 SP3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:112599 SREBF2    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:120727 STAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114124 BioGRID:112649 STAT1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:113188 SUMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:114124 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS; Co-localization; Reconstituted Complex 
    BioGRID:114124 BioGRID:112496 SUMO3    BioGRID  PubMed Co-localization 
    BioGRID:114124 BioGRID:113010 TP53    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114124 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114124 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114124 BioGRID:123701 ZMIZ2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114124 BioGRID:113448 ZNF76    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem (from Pathway Interaction Database)
      Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem
      Hedgehog signaling events mediated by Gli proteins
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL6-mediated signaling events, organism-specific biosystem
      IL6-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of IFNG signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNG signaling, organism-specific biosystemAt least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of...
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
      Sumoylation by RanBP2 regulates transcriptional repression
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS1
    Names
    E3 SUMO-protein ligase PIAS1
    gu-binding protein
    AR interacting protein
    DEAD/H box-binding protein 1
    RNA helicase II-binding protein
    zinc finger, MIZ-type containing 3
    protein inhibitor of activated STAT-1
    protein inhibitor of activated STAT protein 1
    DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016166.1 → NP_057250.1  E3 SUMO-protein ligase PIAS1

      Status: REVIEWED

      Source sequence(s)
      AF167160
      Consensus CDS
      CCDS45290.1
      UniProtKB/Swiss-Prot
      O75925
      Related
      ENSP00000249636, OTTHUMP00000248945, ENST00000249636, OTTHUMT00000419642
      Conserved Domains (3) summary
      pfam14324
      Location:131 – 286
      Blast Score: 443
      PINIT; PINIT domain
      cl02640
      Location:11 – 45
      Blast Score: 96
      SAP; SAP domain
      cl15348
      Location:331 – 379
      Blast Score: 209
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      68346572..68480413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      45180222..45311150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC107871.10 (4779..76712) None
    genomic AC135628.8 (75180..137087) None
    genomic CH471082.1 EAW77804.1
      EAW77805.1
    mRNA AF077951.1 AAC36702.1
    mRNA AF167160.1 AAD49722.1
    mRNA AK094641.1 BAG52901.1
    mRNA AK314515.1 BAG37114.1
    mRNA AY826819.1 AAX18639.1
    mRNA BC053685.1 None
    mRNA BC104646.1 None
    mRNA BC118587.1 AAI18588.1
    mRNA BC121797.1 AAI21798.1
    mRNA EF487997.1 ABP49565.1
    mRNA EF487998.1 ABP49566.1
    mRNA FJ997900.1 ACR77525.1
    mRNA U78524.1 AAB58488.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75925.2 GenPept UniProtKB/Swiss-Prot:O75925
    Q1XBU8 GenPept UniProtKB/TrEMBL:Q1XBU8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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