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    PFS2 Pfs2p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855399, updated on 8-Jan-2012
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    Summary

    Gene symbol
    PFS2
    Gene description
    Pfs2p
    Primary source
    SGD:S000005261
    Locus tag
    YNL317W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: XIV; NC_001146.8 (40619..42016)
    See PFS2 in MapViewer

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Hxt14p Neighboring gene Pha2p Neighboring gene Atp11p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Ghazy MA, et al. Nucleic Acids Res, 2012 Feb 1. PMID 21993299.
    2. Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Fasolo J, et al. Genes Dev, 2011 Apr 1. PMID 21460040.
    3. The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing. Ghazy MA, et al. Mol Cell Biol, 2009 Apr. PMID 19188448.
    4. Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. McClellan AJ, et al. Cell, 2007 Oct 5. PMID 17923092.
    5. Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Collins SR, et al. Mol Cell Proteomics, 2007 Mar. PMID 17200106.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_014082.1 NP_013216.1 CFT2    BIND  PubMed Cft2 (Ydh1) interacts with Pfs2. 
    NP_014082.1 NP_012626.1 FIP1    BIND  PubMed Psf2 interacts with Fip1 as part of the yeast CFII-PFI (CPF) complex. 
    NP_014082.1 NP_013777.1 RNA14    BIND  PubMed Psf2 interacts with Rna14. 
    BioGRID:35522 BioGRID:34850 CCT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:33821 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:32241 CCT6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:32353 CFT1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35522 BioGRID:31387 CFT2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:35522 BioGRID:34640 CLP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:35522 BioGRID:33847 FIP1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:35522 BioGRID:31735 GIP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:36877 GLC7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:33727 HCA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:33439 HGH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:35364 HSC82    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35522 BioGRID:35923 HSP82    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35522 BioGRID:34074 MPE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:34134 PAP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35522 BioGRID:34357 PSK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:35522 BioGRID:31784 PTA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:35522 BioGRID:33404 PTI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:33232 PUF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:32247 REF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:35236 RNA14    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:35522 BioGRID:35614 SSU72    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:35522 BioGRID:31419 STM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:31792 SWD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:34114 SWD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:32266 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:32866 TYR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:32689 YBL010C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:36460 YHI9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:32441 YRA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35522 BioGRID:31545 YSH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:35522 BioGRID:36273 YTH1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Homology

    • Homologs of the PFS2 gene: The PFS2 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice.

    Pathways from BioSystems

    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    contributes_to RNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    mRNA cleavage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mRNA cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mRNA cleavage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mRNA polyadenylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mRNA polyadenylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    mRNA cleavage and polyadenylation specificity factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    mRNA cleavage and polyadenylation specificity factor complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Pfs2p
    NP_014082.1
    • Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8

      Range
      40619..42016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183155.1 → NP_014082.1  Pfs2p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P42841
      Conserved Domains (1) summary
      cd00200
      Location:93 – 377
      Blast Score: 429
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006947.3 DAA10244.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P42841.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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