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PFK2 Pfk2p [ Saccharomyces cerevisiae S288c ]

Gene ID: 855245, updated on 21-Jan-2012

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Summary

Gene symbol: PFK2
Gene description: Pfk2p
Primary source: SGD:S000004818
Locus tag: YMR205C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288c (strain: S288c)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

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Genomic context

Sequence :: Chromosome: XIII; NC_001145.3 (671887..674766, complement)

See PFK2 in MapViewer

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:35383	BioGRID:35461	AEP2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36750	AFG3	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32891	AIM4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:34718	ALA1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35617	ALG9	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32183	ARO1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33104	ARO2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33074	ATG1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32829	ATG14	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31682	ATG17	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32625	ATG8	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35524	ATP11	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33581	ATP12	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35059	ATP18	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32350	ATP5	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34129	AUR1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34230	BAS1	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:32434	BCS1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32965	BIT2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33482	BNS1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35876	BRE5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:36344	BSP1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31446	CBF5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:33427	CBP4	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32859	CDC28	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31579	CDC3	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:35641	CHS1	BioGRID	PubMed	Synthetic Growth Defect; Synthetic Lethality
BioGRID:35383	BioGRID:34441	CKB2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31166	CMK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:35383	BioGRID:31692	CNA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:31485	COA4	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35076	COX14	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33472	CRM1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36292	CTR1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31753	DEP1	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:32898	DER1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34131	DID4	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31443	DPH5	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32904	DUR1,2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36712	EAF5	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35690	EAF7	BioGRID	PubMed	Synthetic Growth Defect
BioGRID:35383	BioGRID:33193	ERV14	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36767	FIR1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35691	FPR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:33503	GCN5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:31830	GDH2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36828	GET2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36090	GLR1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33469	GPI1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32563	GRX2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33002	HAP2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34743	HAP5	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35881	HOL1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32209	HOM2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35787	IDH1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35621	IES2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32368	IPK1	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:34321	IRA2	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:32202	KGD2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31063	KIN82	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:36517	KSP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:35383	BioGRID:34518	LEO1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31709	LEU3	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33495	LSC2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33776	LSM8	BioGRID	PubMed	Two-hybrid
BioGRID:35383	BioGRID:31742	LTE1	BioGRID	PubMed	Synthetic Lethality
BioGRID:35383	BioGRID:33539	MAL11	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35532	MCK1	BioGRID	PubMed	Biochemical Activity
BioGRID:35383	BioGRID:31756	MDM10	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:34241	MED7	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31955	MSS2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33004	MTO1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36511	NMD2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35040	NUP188	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33718	NUP192	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:31790	NUP60	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31052	PAT1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32589	PAU10	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32919	PCS60	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34745	PDE2	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:36903	PET122	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33492	PFK1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; PCA; Phenotypic Enhancement; Synthetic Lethality; Two-hybrid
BioGRID:35383	BioGRID:35280	PGM2	BioGRID	PubMed	Phenotypic Suppression
BioGRID:35383	BioGRID:36147	PHO85	BioGRID	PubMed	Biochemical Activity
BioGRID:35383	BioGRID:34120	PRP40	BioGRID	PubMed	Protein-peptide
BioGRID:35383	BioGRID:32756	PRP6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:35659	PSD1	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:34357	PSK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:35383	BioGRID:31293	PSR2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:36623	PTH1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31881	PTP1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34871	QDR1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33189	RAD6	BioGRID	PubMed	Synthetic Growth Defect
BioGRID:35383	BioGRID:35316	RIM11	BioGRID	PubMed	Biochemical Activity
BioGRID:35383	BioGRID:36705	RIP1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32307	RKM4	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36679	RML2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33204	RNA15	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31911	RPC53	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36458	RPN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:36634	RPN10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:31152	RPN11	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:32035	RPN4	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34363	RPP2A	BioGRID	PubMed	Positive Genetic
BioGRID:35383	BioGRID:34681	RPS10A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:33573	RPS22A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:34513	RPT5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:33870	RSM7	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36869	RSP5	BioGRID	PubMed	Protein-peptide
BioGRID:35383	BioGRID:33466	RTA1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35999	RTC6	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32030	RTK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:35383	BioGRID:33408	RTS3	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32449	RVS167	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:31451	SAM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:32738	SCO1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33496	SDA1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33461	SER2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31897	SFA1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33359	SHY1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32011	SIT4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:31139	SMC1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33481	SMI1	BioGRID	PubMed	Synthetic Growth Defect; Synthetic Lethality
BioGRID:35383	BioGRID:32529	SNF1	BioGRID	PubMed	Biochemical Activity; Synthetic Rescue
BioGRID:35383	BioGRID:31049	SOL2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33499	SOL4	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35241	SOV1	BioGRID	PubMed	Synthetic Growth Defect
BioGRID:35383	BioGRID:36586	SPO12	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:30937	SPS22	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36897	SPT15	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:32783	SPT7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:31330	SPT8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:34959	SSM4	BioGRID	PubMed	Protein-peptide
BioGRID:35383	BioGRID:36187	SUT2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36149	SUV3	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33575	SWE1	BioGRID	PubMed	Biochemical Activity
BioGRID:35383	BioGRID:33524	TAF1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36251	TEF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:33619	TIF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:34414	TIR4	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33075	TOS3	BioGRID	PubMed	Biochemical Activity
BioGRID:35383	BioGRID:33595	TPK1	BioGRID	PubMed	Biochemical Activity
BioGRID:35383	BioGRID:36007	TRE1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32508	TSA2	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31215	UBI4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:36901	UBP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:36174	ULA1	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32658	URA7	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36319	URN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:33044	VAM7	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:31878	YDL233W	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:32180	YDR124W	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:33516	YGR266W	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34999	YIR007W	BioGRID	PubMed	Affinity Capture-MS
BioGRID:35383	BioGRID:33546	YJL213W	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:34150	YKR018C	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35815	YNL010W	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:35866	YNR040W	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36264	YPR097W	BioGRID	PubMed	Negative Genetic
BioGRID:35383	BioGRID:36766	YPT31	BioGRID	PubMed	Negative Genetic

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General gene information

Pathways from BioSystems

Biosynthesis of secondary metabolites, organism-specific biosystem (from KEGG)
Biosynthesis of secondary metabolites, organism-specific biosystem
Biosynthesis of secondary metabolites
Fructose and mannose metabolism, organism-specific biosystem (from KEGG)
Fructose and mannose metabolism, organism-specific biosystem
Fructose and mannose metabolism
Fructose and mannose metabolism, conserved biosystem (from KEGG)
Fructose and mannose metabolism, conserved biosystem
Fructose and mannose metabolism
Galactose metabolism, organism-specific biosystem (from KEGG)
Galactose metabolism, organism-specific biosystem
Galactose metabolism
Galactose metabolism, conserved biosystem (from KEGG)
Galactose metabolism, conserved biosystem
Galactose metabolism
Glucose metabolism, organism-specific biosystem (from REACTOME)
Glucose metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycolysis, organism-specific biosystem (from REACTOME)
Glycolysis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystem (from KEGG)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystem (from KEGG)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Methane metabolism, organism-specific biosystem (from KEGG)
Methane metabolism, organism-specific biosystemMethane is metabolized principally by methanotrophs and the methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a ...
Methane metabolism, conserved biosystem (from KEGG)
Methane metabolism, conserved biosystemMethane is metabolized principally by methanotrophs and the methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a ...
Pentose phosphate pathway, organism-specific biosystem (from KEGG)
Pentose phosphate pathway, organism-specific biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...
Pentose phosphate pathway, conserved biosystem (from KEGG)
Pentose phosphate pathway, conserved biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...
glycolysis, organism-specific biosystem (from BIOCYC)
glycolysis, organism-specific biosystem
glycolysis
superpathway of glucose fermentation, organism-specific biosystem (from BIOCYC)
superpathway of glucose fermentation, organism-specific biosystem
superpathway of glucose fermentation

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
6-phosphofructokinase activity	IEA Inferred from Electronic Annotation more info
6-phosphofructokinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
ATP binding	IEA Inferred from Electronic Annotation more info
catalytic activity	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
mRNA binding	IDA Inferred from Direct Assay more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
glycolysis	IDA Inferred from Direct Assay more info	PubMed
glycolysis	IEA Inferred from Electronic Annotation more info
glycolysis	IMP Inferred from Mutant Phenotype more info	PubMed
metabolic process	IEA Inferred from Electronic Annotation more info
phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
6-phosphofructokinase complex	IEA Inferred from Electronic Annotation more info
6-phosphofructokinase complex	IMP Inferred from Mutant Phenotype more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Names: Pfk2p

NP_013932.1

EC 2.7.1.11

Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3

Range

671887..674766, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182712.1 → NP_013932.1 Pfk2p [Saccharomyces cerevisiae S288c]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P16862

Conserved Domains (2) summary

TIGR02478
Location:197 – 957
Blast Score: 2983

6PF1K_euk; 6-phosphofructokinase, eukaryotic type

cl00204
Location:196 – 947
Blast Score: 2704

PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. ...