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PAH1 phosphatidate phosphatase PAH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855201, updated on 13-Apr-2024

Summary

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Gene symbol
PAH1
Gene description
phosphatidate phosphatase PAH1
Primary source
SGD:S000004775
Locus tag
YMR165C
See related
AllianceGenome:SGD:S000004775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SMP2
Summary
Enables phosphatidate phosphatase activity and transcription cis-regulatory region binding activity. Involved in several processes, including lipid droplet organization; triglyceride biosynthetic process; and vacuole fusion, non-autophagic. Located in several cellular components, including lipid droplet; nuclear membrane; and vacuole. Is extrinsic component of membrane. Used to study lipid metabolism disorder and myoglobinuria. Orthologous to human LPIN1 (lipin 1); LPIN2 (lipin 2); and LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (590040..592628, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene Mss11p Neighboring gene Mme1p Neighboring gene mismatch repair ATPase MLH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutant phosphatidate phosphatase Pah1-W637A exhibits altered phosphorylation, membrane association, and enzyme function in yeast. Park Y, et al. J Biol Chem, 2022 Feb. PMID 35026226, Free PMC Article
  2. Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer. Kwiatek JM, et al. J Lipid Res, 2020 Aug. PMID 32540926, Free PMC Article
  3. A conserved tryptophan within the WRDPLVDID domain of yeast Pah1 phosphatidate phosphatase is required for its in vivo function in lipid metabolism. Park Y, et al. J Biol Chem, 2017 Dec 1. PMID 29066621, Free PMC Article
  4. An evolutionarily conserved phosphatidate phosphatase maintains lipid droplet number and endoplasmic reticulum morphology but not nuclear morphology. Pillai AN, et al. Biol Open, 2017 Nov 15. PMID 28954739, Free PMC Article
  5. Pah1p negatively regulates the expression of V-ATPase genes as well as vacuolar acidification. Sherr GL, et al. Biochem Biophys Res Commun, 2017 Sep 23. PMID 28756231

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphatidate phosphatase Pah1 contains a novel RP domain that regulates its phosphorylation and function in yeast lipid synthesis.
    Title: Phosphatidate phosphatase Pah1 contains a novel RP domain that regulates its phosphorylation and function in yeast lipid synthesis.
  2. Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
    Title: Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
  3. Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
    Title: Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
  4. Mutant phosphatidate phosphatase Pah1-W637A exhibits altered phosphorylation, membrane association, and enzyme function in yeast.
    Title: Mutant phosphatidate phosphatase Pah1-W637A exhibits altered phosphorylation, membrane association, and enzyme function in yeast.
  5. Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
    Title: Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
  6. NLIP and HAD-like Domains of Pah1 and Lipin 1 Phosphatidate Phosphatases Are Essential for Their Catalytic Activities.
    Title: NLIP and HAD-like Domains of Pah1 and Lipin 1 Phosphatidate Phosphatases Are Essential for Their Catalytic Activities.
  7. Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer.
    Title: Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer.
  8. The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
    Title: The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
  9. Results indicate that phosphatidate phosphatase PAH1 (Pah1) is phosphorylated by the serine/threonine protein kinase YCK1 (YCK1)-encoded casein kinase I (CKI), regulating Pah1 catalytic activity and phosphorylation.
    Title: Yck1 casein kinase I regulates the activity and phosphorylation of Pah1 phosphatidate phosphatase from Saccharomyces cerevisiae.
  10. the TORC1-Nem1/Spo7-Pah1 axis is a master regulator of not only macroautophagy but also microautophagy in budding yeast
    Title: The TORC1-Nem1/Spo7-Pah1/lipin axis regulates microautophagy induction in budding yeast.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid droplet organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasmid maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidate phosphatase PAH1
NP_013888.1
  • Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    590040..592628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182669.1 → NP_013888.1  TPA: phosphatidate phosphatase PAH1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013888.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZY7, P32567
    UniProtKB/TrEMBL
    A0A8H4BXI3, G2WKL8
    Conserved Domains (1) summary
    COG5083
    Location:1 → 609
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32567.1

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