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    UBX4 Ubx4p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855089, updated on 4-Feb-2012
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    Summary

    Gene symbol
    UBX4
    Gene description
    Ubx4p
    Primary source
    SGD:S000004671
    Locus tag
    YMR067C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CUI1
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    Genomic context

    Sequence :
    Chromosome: XIII; NC_001145.3 (404323..405573, complement)
    See UBX4 in MapViewer

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Kar5p Neighboring gene Sov1p Neighboring gene Avo2p Neighboring gene Nat4p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    2. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Magtanong L, et al. Nat Biotechnol, 2011 May 15. PMID 21572441.
    3. Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Verma R, et al. Mol Cell, 2011 Jan 7. PMID 21211725.
    4. A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Finnigan GC, et al. Genetics, 2011 Mar. PMID 21196517.
    5. A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. Tran JR, et al. J Biol Chem, 2011 Feb 18. PMID 21148305.

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The observation that Ubx2 and Ubx4 are not found together in one complex with Cdc48 suggests several distinct steps in modulating the activity and localization of Cdc48 in endoplasmic reciculum
      Title: Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:35242 BioGRID:32931 ABD1    BioGRID  PubMed Positive Genetic 
    BioGRID:35242 BioGRID:33916 AIM27    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:35336 ATG16    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:35876 BRE5    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:31825 CDC13    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35242 BioGRID:31937 CDC48    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Dosage Rescue; Negative Genetic; Two-hybrid 
    BioGRID:35242 BioGRID:33405 CHO2    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:31754 CYS3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35242 BioGRID:33952 DOA1    BioGRID  PubMed Two-hybrid 
    BioGRID:35242 BioGRID:33842 EMC2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:35099 ERV41    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35242 BioGRID:32418 ESC2    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:34600 GEP3    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:33226 GET1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:36853 GLE2    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:32388 GPI8    BioGRID  PubMed Positive Genetic 
    BioGRID:35242 BioGRID:34949 GVP36    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:33666 GWT1    BioGRID  PubMed Positive Genetic 
    BioGRID:35242 BioGRID:34598 HIS3    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:35338 HLJ1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:33874 ILM1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:34321 IRA2    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:33845 JSN1    BioGRID  PubMed Two-hybrid 
    BioGRID:35242 BioGRID:33726 KAR2    BioGRID  PubMed Positive Genetic 
    BioGRID:35242 BioGRID:36429 NEM1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35242 BioGRID:32369 OMS1    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:33829 OPI3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35242 BioGRID:35080 PGA3    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:35300 PKR1    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:35306 POM152    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:35445 PPA2    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:33383 PRE9    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:31190 QCR6    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:30977 RER1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:36389 RPL8A    BioGRID  PubMed Positive Genetic 
    BioGRID:35242 BioGRID:31152 RPN11    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:32035 RPN4    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:35242 BioGRID:32047 RPT2    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:34649 RPT4    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:31536 SEC22    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:31638 SEC61    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:36087 SEC62    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:32420 SEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:32641 SHP1    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:32561 SMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35242 BioGRID:31054 SRB8    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35242 BioGRID:31882 SSB1    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:32977 SSH1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:33091 SUT1    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:33595 TPK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:35242 BioGRID:35156 UBX2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35242 BioGRID:33348 VMA21    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35242 BioGRID:32103 VMS1    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:35242 BioGRID:33349 VOA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35242 BioGRID:34133 VPS1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:35242 BioGRID:35675 YCK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:35242 BioGRID:35327 YIM1    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:35651 YNL181W    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:35969 YPL216W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35242 BioGRID:36766 YPT31    BioGRID  PubMed Negative Genetic 
    BioGRID:35242 BioGRID:33618 YUR1    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    ER-associated protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		  
    ER-associated protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sporulation resulting in formation of a cellular spore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    peripheral to membrane of membrane fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Ubx4p
    NP_013783.1
    • UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3

      Range
      404323..405573, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182565.1 → NP_013783.1  Ubx4p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P54730
      Conserved Domains (2) summary
      pfam11470
      Location:5 – 71
      Blast Score: 202
      TUG; GLUT4 regulating protein TUG
      cl00155
      Location:277 – 351
      Blast Score: 170
      UBQ; Ubiquitin-like proteins
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006946.2 DAA09965.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P54730.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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