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PEX12 ubiquitin-protein ligase peroxin 12 [ Saccharomyces cerevisiae S288c ]

Gene ID: 855041, updated on 14-Dec-2014
Gene symbol
PEX12
Gene description
ubiquitin-protein ligase peroxin 12
Primary source
SGD:S000004628
Locus tag
YMR026C
Gene type
protein coding
RNA name
ubiquitin-protein ligase peroxin 12
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PAS11
See PEX12 in MapViewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (324236..325435, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL3 Neighboring gene Csi1p Neighboring gene hypothetical protein Neighboring gene Tap42p

  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to peroxisome IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
peroxisomal importomer complex IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 
Names
ubiquitin-protein ligase peroxin 12
NP_013739.1
  • C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 

    Range
    324236..325435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182522.1NP_013739.1  ubiquitin-protein ligase peroxin 12 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_013739.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q04370
    Conserved Domains (2) summary
    smart00184
    Location:334371
    RING; Ring finger
    pfam04757
    Location:41294
    Pex2_Pex12; Pex2 / Pex12 amino terminal region