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MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 [ Homo sapiens (human) ]

Gene ID: 8550, updated on 12-May-2016
Official Symbol
MAPKAPK5provided by HGNC
Official Full Name
mitogen-activated protein kinase-activated protein kinase 5provided by HGNC
Primary source
HGNC:HGNC:6889
See related
Ensembl:ENSG00000089022 HPRD:09467; MIM:606723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MK5; MK-5; PRAK; MAPKAP-K5
Summary
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Orthologs
Location:
12q24.13
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (111842228..111901619)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112280032..112331228)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family member 10 Neighboring gene aldehyde dehydrogenase 2 family (mitochondrial) Neighboring gene microRNA 6761 Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene ribosomal protein S2 pseudogene 41 Neighboring gene transmembrane protein 116 Neighboring gene ADAM metallopeptidase domain 1A (pseudogene) Neighboring gene ADAM metallopeptidase domain 1B (pseudogene) Neighboring gene solute carrier family 25 member 3 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
    Signaling mediated by p38-alpha and p38-beta
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
p53 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stress-induced premature senescence IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
MAP kinase-activated protein kinase 5
Names
MAPK-activated protein kinase 5
MAPKAP kinase 5
MAPKAPK-5
p38-regulated/activated protein kinase
NP_003659.2
NP_620777.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003668.3NP_003659.2  MAP kinase-activated protein kinase 5 isoform 1

    See identical proteins and their annotated locations for NP_003659.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript.
    Source sequence(s)
    AK122767, AL110301, BC041049, BG502445
    Consensus CDS
    CCDS44976.1
    UniProtKB/Swiss-Prot
    Q8IW41
    Related
    ENSP00000449667, OTTHUMP00000241666, ENST00000550735, OTTHUMT00000405015
    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  2. NM_139078.2NP_620777.1  MAP kinase-activated protein kinase 5 isoform 2

    See identical proteins and their annotated locations for NP_620777.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an extra 6 nt segment in the coding region when compared to variant 1. It encodes an isoform (2) longer by 2 aa, as compared to isoform 1.
    Source sequence(s)
    AK122767, AL110301, BC000833, BC041049, BG502445
    Consensus CDS
    CCDS44975.1
    UniProtKB/Swiss-Prot
    Q8IW41
    Related
    ENSP00000449381, OTTHUMP00000241669, ENST00000551404, OTTHUMT00000405019
    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    111842228..111901619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538911.1XP_011537213.1  

    See identical proteins and their annotated locations for XP_011537213.1

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  2. XM_011538915.1XP_011537217.1  

    See identical proteins and their annotated locations for XP_011537217.1

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  3. XM_011538910.1XP_011537212.1  

    See identical proteins and their annotated locations for XP_011537212.1

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  4. XM_011538914.1XP_011537216.1  

    See identical proteins and their annotated locations for XP_011537216.1

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  5. XM_011538916.1XP_011537218.1  

    See identical proteins and their annotated locations for XP_011537218.1

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  6. XM_011538909.1XP_011537211.1  

    See identical proteins and their annotated locations for XP_011537211.1

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  7. XM_011538917.1XP_011537219.1  

    Conserved Domains (2) summary
    smart00220
    Location:26274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:15274
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011538918.1XP_011537220.1  

    Conserved Domains (2) summary
    smart00220
    Location:26235
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:15235
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011538919.1XP_011537221.1  

    Conserved Domains (2) summary
    smart00220
    Location:4211
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2211
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011538913.1XP_011537215.1  

    See identical proteins and their annotated locations for XP_011537215.1

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  11. XM_011538912.1XP_011537214.1  

    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  12. XM_011538920.1XP_011537222.1  

    See identical proteins and their annotated locations for XP_011537222.1

    Conserved Domains (1) summary
    cl21453
    Location:1124
    PKc_like; Protein Kinases, catalytic domain
  13. XM_011538921.1XP_011537223.1  

    See identical proteins and their annotated locations for XP_011537223.1

    Conserved Domains (1) summary
    cl21453
    Location:1124
    PKc_like; Protein Kinases, catalytic domain
  14. XM_011538922.1XP_011537224.1  

    See identical proteins and their annotated locations for XP_011537224.1

    Conserved Domains (1) summary
    cl21453
    Location:1124
    PKc_like; Protein Kinases, catalytic domain
  15. XM_005253979.2XP_005254036.2  

    Conserved Domains (1) summary
    cl21453
    Location:171
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_944807.1 RNA Sequence

  2. XR_944806.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    112247967..112299159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)