MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 [Homo sapiens] - Gene

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Summary

Official Symbol: MAPKAPK5provided by HGNC
Official Full Name: mitogen-activated protein kinase-activated protein kinase 5provided by HGNC
Primary source: HGNC:6889
See related: Ensembl:ENSG00000089022; HPRD:09467; MIM:606723; Vega:OTTHUMG00000169605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MK5; MK-5; PRAK; MAPKAP-K5
Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 12q24.13

Sequence :: Chromosome: 12; NC_000012.11 (112280279..112331228)

See MAPKAPK5 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IGF2BP1 promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 and PTEN
Title: IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.
Rheb inactivation by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
Title: Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
Title: Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
This review discusses the different characteristics of regulating the activity and subcellular localization of MK5 and RSK1 by PKA and the functional implications of these interactions.
Title: Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5.
Several binding motifs for heat shock factor are dispersed in the mouse and rat promoter, and temperature shock transiently enhanced the MAP-kinase-activated kinase 5 transcript levels.
Title: The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.
Data defined a novel MK5 interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5.
Title: Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.
results imply that MK5 is involved in Hsp27-controlled F-actin dynamics in response to activation of the cAMP-dependent protein kinase pathway.
Title: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_003659.2	NP_077734.1	PLA2G4A	BIND	PubMed	PRAK1 phosphorylates cPLA2.
Q8IW41	P15336	ATF2	HPRD	PubMed
Q8IW41	O00418	EEF2K	HPRD	PubMed
Q8IW41	P06730	EIF4E	HPRD	PubMed
Q8IW41	Q13541	EIF4EBP1	HPRD	PubMed
Q8IW41	P13807	GYS1	HPRD	PubMed
Q8IW41	P04792	HSPB1	HPRD	PubMed
Q8IW41	P05412	JUN	HPRD	PubMed
Q8IW41	P28482	MAPK1	HPRD	PubMed
Q8IW41	Q15759	MAPK11	HPRD	PubMed
Q8IW41	P53778	MAPK12	HPRD	PubMed
Q8IW41	O15264	MAPK13	HPRD	PubMed
Q8IW41	Q16539	MAPK14	HPRD	PubMed
Q8IW41	P31152	MAPK4	HPRD	PubMed
Q8IW41	Q16659	MAPK6	HPRD	PubMed
Q8IW41	P45984	MAPK9	HPRD	PubMed
Q8IW41	P02686	MBP	HPRD	PubMed
Q8IW41	P35749	MYH11	HPRD	PubMed
Q8IW41	P47712	PLA2G4A	HPRD	PubMed
Q8IW41	P04637	TP53	HPRD	PubMed
BioGRID:114120	BioGRID:109547	HSPB1	BioGRID	PubMed	Biochemical Activity
BioGRID:114120	BioGRID:109548	HSPB2	BioGRID	PubMed	Biochemical Activity
BioGRID:114120	BioGRID:107819	MAPK14	BioGRID	PubMed	Two-hybrid
BioGRID:114120	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid
BioGRID:114120	BioGRID:247522	Nedd4	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:114120	BioGRID:112057	RPL13	BioGRID	PubMed	Two-hybrid
BioGRID:114120	BioGRID:115717	TAB1	BioGRID	PubMed	Two-hybrid
BioGRID:114120	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114120	BioGRID:114010	ZNF282	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
MAP kinase kinase activity	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
p53 binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
MAPK cascade	TAS Traceable Author Statement more info	PubMed
Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
activation of MAPK activity	TAS Traceable Author Statement more info	PubMed
negative regulation of TOR signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
protein autophosphorylation	IDA Inferred from Direct Assay more info
regulation of translation	IDA Inferred from Direct Assay more info
response to stress	IDA Inferred from Direct Assay more info
signal transduction	TAS Traceable Author Statement more info	PubMed
stress-induced premature senescence	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: MAP kinase-activated protein kinase 5

Names: MAP kinase-activated protein kinase 5; MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein kinase 5; p38-regulated/activated protein kinase

NP_003659.2

EC 2.7.11.1

NP_620777.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003668.2 → NP_003659.2 MAP kinase-activated protein kinase 5 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the more frequently occurring transcript.

Source sequence(s)

AF032437, AL110301, AW780199

Consensus CDS

CCDS44976.1

UniProtKB/Swiss-Prot

Q8IW41

Related

ENSP00000409640, ENST00000428907

Conserved Domains (2) summary

smart00220
Location:26 – 304
Blast Score: 653

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:28 – 303
Blast Score: 472

PKc_like; Protein Kinases, catalytic domain
NM_139078.1 → NP_620777.1 MAP kinase-activated protein kinase 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an extra 6 nt segment in the coding region when compared to variant 1. It encodes an isoform (2) longer by 2 aa, as compared to isoform 1.

Source sequence(s)

AL110301, AW780199, BC000833

Consensus CDS

CCDS44975.1

UniProtKB/Swiss-Prot

Q8IW41

Related

ENSP00000202788, ENST00000202788

Conserved Domains (2) summary

smart00220
Location:26 – 304
Blast Score: 654

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:28 – 303
Blast Score: 472

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

112280279..112331228

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

109293619..109344645

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC003029.5 (51255..102204)	None
genomic	AF032437.1	AAC39863.1
genomic	CH471054.1	EAW97979.1
		EAW97980.1
		EAW97981.1
mRNA	AK122767.1	BAG53717.1
mRNA	AL110301.1	CAB53747.1
mRNA	AW780199.1	None
mRNA	BC000833.1	AAH00833.1
mRNA	BC041049.1	AAH41049.1
mRNA	BC047284.1	AAH47284.2