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    SPT5 Spt5p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854999, updated on 6-May-2012
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    Summary

    Gene symbol
    SPT5
    Gene description
    Spt5p
    Primary source
    SGD:S000004470
    Locus tag
    YML010W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: XIII
    Sequence :
    Chromosome: XIII; NC_001145.3 (247677..250868)
    See SPT5 in MapViewer

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Erv25p Neighboring gene Rad33p Neighboring gene Mrpl39p Neighboring gene Erg6p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I. Mayer A, et al. Mol Cell Biol, 2012 Apr. PMID 22290438.
    2. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. Friederichs JM, et al. PLoS Genet, 2011 Nov. PMID 22125491.
    3. The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2. Schillewaert S, et al. Mol Cell Biol, 2012 Jan. PMID 22083961.
    4. FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation. Stevens JR, et al. PLoS One, 2011. PMID 22022426.
    5. Rpa43 and its partners in the yeast RNA polymerase I transcription complex. Beckouët F, et al. FEBS Lett, 2011 Nov 4. PMID 21983101.

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Chromatin immunoprecipitation (ChIP) revealed that the Spt5 C-terminal region is required for normal recruitment of pre-mRNA cleavage factor I (CFI) to the 3' ends of Saccharomyces cerevisiae genes.
      Title: The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I.
    2. Spt5p plays both positive and negative roles in transcription by Pol I.
      Title: The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively.
    3. Spt5 is recruited to the rDNA early in transcription and propose that it plays an important role in ribosomal RNA synthesis through direct binding to the Pol I complex.
      Title: Yeast transcription elongation factor Spt5 associates with RNA polymerase I and RNA polymerase II directly.
    4. Data provide evidence implicating the yeast DSIF complex (Spt4/5) and RNA polymerase II phosphorylation by Kin28 and Ctk1 in the recruitment of Rpd3S to active genes.
      Title: DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.
    5. She2p interacts in vivo with the elongating forms of RNA polymerase II (pol II) via the transcription elongation factor Spt4-Spt5
      Title: Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud.
    6. suppression of spt5 can result from loss of histone H3 lysines 4 or 36 methylation, or reduced recruitment of Chd1 or the Rpd3S complex
      Title: Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription.
    7. Spt5 CTR suppresses Rad26-independent TCR by serving as a platform for assembly of a multiple protein suppressor complex that is associated with Pol II.
      Title: The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair.
    8. Data show that Bur1 phosphorylates the Spt5 C-terminal repeat domain (CTD) both in vivo and in isolated elongation complexes in vitro.
      Title: Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.
    9. Spt5 C-terminal domain is a substrate of BUR kinase and a platform for the association of proteins that promote both transcription elongation and histone modification in transcribed regions
      Title: Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.
    10. Structural and evolutionary perspective of Spt4-Spt5 complex and suggests that it is an ancient, core component of the transcription elongation machinery.
      Title: Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation.
    Submit: New GeneRIF Correction See all (12)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_013703.1 NP_011577.1 SPT4    BIND  PubMed Spt5 interacts with Spt4 
    BioGRID:35159 BioGRID:32931 ABD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32891 AIM4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35135 AMD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33738 BBC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:107140 BRCA1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35159 BioGRID:35876 BRE5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:30969 BUD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31446 CBF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31745 CCR4    BioGRID  PubMed Dosage Rescue 
    BioGRID:35159 BioGRID:31065 CDC39    BioGRID  PubMed Dosage Rescue 
    BioGRID:35159 BioGRID:31676 CDC73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33121 CEG1    BioGRID  PubMed Affinity Capture-MS; Synthetic Lethality 
    BioGRID:35159 BioGRID:35957 CET1    BioGRID  PubMed Affinity Capture-MS; Synthetic Lethality 
    BioGRID:35159 BioGRID:31387 CFT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36917 CHD1    BioGRID  PubMed Affinity Capture-Western; Synthetic Rescue 
    BioGRID:35159 BioGRID:34955 CKA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34460 CKA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33227 CKB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34441 CKB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36580 CRP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34084 CSE4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33997 CTK1    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality; Synthetic Rescue 
    BioGRID:35159 BioGRID:34272 CTR9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32025 DBP10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33172 DBP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31544 DBP9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35947 DIM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36833 DOT6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35002 DSN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33205 DST1    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:35159 BioGRID:33978 ELF1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:35159 BioGRID:32422 ESF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33773 ESS1    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:35159 BioGRID:35456 FCP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35159 BioGRID:32186 FIN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:35159 BioGRID:32336 GCN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33503 GCN5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-RNA 
    BioGRID:35159 BioGRID:33727 HCA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32710 HHF1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35159 BioGRID:32711 HHT1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:35159 BioGRID:34252 HRP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:35159 BioGRID:34392 HTZ1    BioGRID  PubMed Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:35159 BioGRID:31643 IKI3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35111 IMD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36342 JIP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31954 KIN28    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35159 BioGRID:35695 KRE33    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34194 LAS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34518 LEO1    BioGRID  PubMed Affinity Capture-MS; Synthetic Rescue 
    BioGRID:35159 BioGRID:36125 LGE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31149 LOC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31177 LSB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32613 MAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33739 MPS3    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35159 BioGRID:34123 MRT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33705 MTR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36227 NHP6A    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:35159 BioGRID:32795 NHP6B    BioGRID  PubMed Affinity Capture-MS; Synthetic Lethality 
    BioGRID:35159 BioGRID:36088 NOG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32040 NOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31913 NOP14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35762 NOP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33346 NOP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32489 NPL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35588 NRD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35159 BioGRID:33140 NSA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36918 PAB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32973 PAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Rescue 
    BioGRID:35159 BioGRID:34134 PAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35097 POB3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35159 BioGRID:35721 POL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35577 POL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32130 PPH3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34120 PRP40    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:35159 BioGRID:35633 PSY2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:35159 BioGRID:32651 PSY4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32547 PUF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33788 RAD26    BioGRID  PubMed Dosage Rescue; Synthetic Rescue 
    BioGRID:35159 BioGRID:33806 RAD7    BioGRID  PubMed Synthetic Rescue 
    BioGRID:35159 BioGRID:33033 RAI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35725 RAS2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35159 BioGRID:32247 REF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34612 RFC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36631 RIX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35426 RKR1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35159 BioGRID:32148 RLI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35236 RNA14    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:35159 BioGRID:33204 RNA15    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:35159 BioGRID:33082 ROK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36188 RPA135    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:35159 BioGRID:34724 RPA190    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:35159 BioGRID:33610 RPA34    BioGRID  PubMed Reconstituted Complex 
    BioGRID:35159 BioGRID:34723 RPA43    BioGRID  PubMed Two-hybrid 
    BioGRID:35159 BioGRID:35591 RPA49    BioGRID  PubMed Affinity Capture-MS; Phenotypic Enhancement; Reconstituted Complex; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:35159 BioGRID:34399 RPB11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34547 RPB2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex; Synthetic Rescue 
    BioGRID:35159 BioGRID:34967 RPB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33617 RPB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32853 RPB5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32464 RPB7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34618 RPB8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33178 RPB9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36577 RPC10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36277 RPC40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31152 RPN11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31921 RPO21    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Synthetic Growth Defect 
    BioGRID:35159 BioGRID:36359 RPO26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34011 RRN3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:35159 BioGRID:32143 RRP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35407 RRP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36869 RSP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32996 RTF1    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:35159 BioGRID:35630 RTT106    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35159 BioGRID:31689 SEN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33181 SGF73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36334 SGV1    BioGRID  PubMed Biochemical Activity; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:35159 BioGRID:31186 SMC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33681 SMC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32561 SMT3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35159 BioGRID:36299 SPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33049 SPT16    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Lethality 
    BioGRID:35159 BioGRID:33308 SPT4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Dosage Rescue; Synthetic Lethality 
    BioGRID:35159 BioGRID:33361 SPT6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Lethality 
    BioGRID:35159 BioGRID:32783 SPT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36137 SSN3    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:35159 BioGRID:36257 SUA7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35211 SUB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36987 SUS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36146 SVL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32199 TAF12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36052 TAF14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32895 TAF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33139 TAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33438 TFG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33249 TFG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36805 THO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36336 TIF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:36218 TIF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33770 TMA22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32511 TOM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33595 TPK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35981 TPK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31998 TSR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:35159 BioGRID:36901 UBP3    BioGRID  PubMed Co-purification 
    BioGRID:35159 BioGRID:35401 UBP8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:35053 UFO1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:35159 BioGRID:36319 URN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:31667 VIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32322 YDR266C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33299 YGR054W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:34652 YOR262W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:32441 YRA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:35159 BioGRID:33951 YRA2    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA polymerase II core binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    core RNA polymerase II binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    core RNA polymerase II binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    core RNA polymerase II binding transcription factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription elongation from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription elongation, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription elongation from RNA polymerase II promoter IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription from RNA polymerase I promoter IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription-coupled nucleotide-excision repair IGI
    Inferred from Genetic Interaction
    more info
    		  
    Component Evidence Code Pubs
    DSIF complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription elongation factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
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    General protein information

    Names
    Spt5p
    NP_013703.1
    • Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3

      Range
      247677..250868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182366.1 → NP_013703.1  Spt5p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P27692
      Conserved Domains (5) summary
      COG5164
      Location:441 – 1059
      Blast Score: 1800
      SPT5; Transcription elongation factor [Transcription]
      TIGR00405
      Location:311 – 417
      Blast Score: 94
      L26e_arch; ribosomal protein L24p/L26e, archaeal
      cd09888
      Location:287 – 360
      Blast Score: 187
      NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
      cl00354
      Location:802 – 832
      Blast Score: 85
      KOW; KOW motif
      pfam11942
      Location:180 – 280
      Blast Score: 104
      Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006946.2 DAA09888.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27692.1 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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