U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

USA1 Usa1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854979, updated on 27-Jan-2024

Summary

Go to the top of the page Help
Gene symbol
USA1
Gene description
Usa1p
Primary source
SGD:S000004491
Locus tag
YML029W
See related
AllianceGenome:SGD:S000004491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables molecular adaptor activity. Involved in mRNA splicing, via spliceosome; positive regulation of protein autoubiquitination; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum membrane. Part of Hrd1p ubiquitin ligase ERAD-L complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (217362..219878)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ndc1p Neighboring gene Rcf1p Neighboring gene thioredoxin peroxidase TSA1 Neighboring gene Yox1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. Benitez EM, et al. FEBS Lett, 2011 Oct 3. PMID 21871892
  2. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. Carroll SM, et al. J Biol Chem, 2010 Feb 19. PMID 19940128, Free PMC Article
  3. Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1. Peterson BG, et al. Elife, 2019 Nov 12. PMID 31713515, Free PMC Article
  4. Direct and essential function for Hrd3 in ER-associated degradation. Vashistha N, et al. Proc Natl Acad Sci U S A, 2016 May 24. PMID 27170191, Free PMC Article
  5. N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Zattas D, et al. Mol Biol Cell, 2013 Apr. PMID 23363603, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Usa1 has two important roles in ERAD substrate ubiquitylation
    Title: Usa1 protein facilitates substrate ubiquitylation through two separate domains.
  2. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.
    Title: Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ERAD pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Hrd1p ubiquitin ligase ERAD-L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Hrd1p ubiquitin ligase ERAD-L complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Usa1p
NP_013683.1
  • Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    217362..219878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182387.1 → NP_013683.1  TPA: Usa1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013683.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZE5, Q03714
    UniProtKB/TrEMBL
    A0A8H4FB33, B3LLM3, B5VP97, C8ZEH5
    Conserved Domains (1) summary
    cl28922
    Location:276 → 341
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03714.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous