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    URM1 Urm1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854809, updated on 6-May-2012
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    Summary

    Gene symbol
    URM1
    Gene description
    Urm1p
    Primary source
    SGD:S000001270
    Locus tag
    YIL008W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: IX
    Sequence :
    Chromosome: IX; NC_001141.2 (342536..342835)
    See URM1 in MapViewer

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene Faa3p Neighboring gene Nas2p Neighboring gene Yia6p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast. Chang HY, et al. G3 (Bethesda), 2011 Aug. PMID 22384331.
    2. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    3. La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast. Schenk L, et al. RNA, 2012 Mar. PMID 22271760.
    4. Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. Boettner DR, et al. Mol Biol Cell, 2011 Oct. PMID 21849475.
    5. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Petroski MD, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245332.

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. observations suggest that Urm1 activation is more similar to that of a prokaryotic sulfur carrier protein than that of a ubiquitin-like protein
      Title: Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.
    2. Urm1p, the most ancient UBL, acts as a sulphur carrier in the process of eukaryotic transfer RNA (tRNA) modification, providing a possible evolutionary link between Ubiquitin-like proteins and sulphur transfer
      Title: Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.
    3. ubiquitin-like protein Urm1 and ubiquitin-activating enzyme-like protein Uba4, as well as Tuc1 and Tuc2, were strictly required for tRNA thio-modification
      Title: Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems.
    4. Urm1 forms a dimer either in solution or in the crystal packing. The dimeric form will block the mobile C-terminal Gly-Gly, which could provide an autoprotection of this active site.
      Title: Crystal structure of the dimeric Urm1 from the yeast Saccharomyces cerevisiae.
    5. Data describe the solution NMR structure of the Urm1 (ubiquitin-related modifier-1) protein from Saccharomyces cerevisiae.
      Title: Solution structure of Urm1 and its implications for the origin of protein modifiers.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:34984 BioGRID:31843 ACK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:31107 ACT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:31382 AHP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:34984 BioGRID:32891 AIM4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:36025 AIM44    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32320 AKR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33145 ARC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35861 ARC35    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:36440 ARD1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33104 ARO2    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36562 ARP1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34984 BioGRID:34535 ARP8    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:34957 BCY1    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:32897 BEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35569 BNI1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:31987 BRE1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35549 CAF40    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:31579 CDC3    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:31676 CDC73    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:33242 CDH1    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:35540 CLA4    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:34984 BioGRID:33419 CLC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36001 CTI6    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:34447 DBP5    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34984 BioGRID:30968 DCC1    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:31148 DEG1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:31753 DEP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:34085 ELM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33453 ELP2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:36095 ELP3    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:36079 ELP4    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35492 ELP6    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:34635 ESA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:31502 EST1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:31125 GAT1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:34984 BioGRID:33226 GET1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:36828 GET2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35312 GID8    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35676 GIM3    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:36728 GIM4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35049 GIM5    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34984 BioGRID:36877 GLC7    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34984 BioGRID:36776 GLN3    BioGRID  PubMed Synthetic Rescue 
    BioGRID:34984 BioGRID:34469 GYP1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:32277 HTA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36621 IKI1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:31643 IKI3    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35474 JNM1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34984 BioGRID:36125 LGE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:34058 LHS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:34615 MCT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35943 MDL2    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35077 MSC1    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:34711 MYO2    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:34984 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34984 BioGRID:35707 NCS2    BioGRID  PubMed Affinity Capture-MS; Positive Genetic; Two-hybrid 
    BioGRID:34984 BioGRID:33045 NCS6    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:34984 BioGRID:34213 NUP133    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33320 PAC10    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:33628 PBS2    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:34438 PEP12    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35726 PHO23    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:34403 PHO80    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35573 PIK1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:32680 POP8    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:33334 PRP31    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36350 PRP4    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32547 PUF6    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:32270 RAD9    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34984 BioGRID:32148 RLI1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35413 RNA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33204 RNA15    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:31631 ROM2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35511 RPD3    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33117 RPL1B    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:34225 RPL40B    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:31980 RPP1A    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32143 RRP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32996 RTF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:30988 RVS161    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:32449 RVS167    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33953 SAC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32738 SCO1    BioGRID  PubMed Positive Genetic 
    BioGRID:34984 BioGRID:36865 SCS2    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35451 SCS7    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:31536 SEC22    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33149 SEH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:34400 SIN3    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:34203 SIS2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:32566 SLF1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34984 BioGRID:34412 SLG1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:36461 SLT2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35293 SPC24    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32365 SSF2    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36419 STE20    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34984 BioGRID:30951 STE50    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33246 SWC4    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34984 BioGRID:33753 SYS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35090 TAF8    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:35200 TAP42    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32820 TEF2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:35744 TPM1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:33437 TYS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36544 UBA4    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity; Two-hybrid 
    BioGRID:34984 BioGRID:35609 URE2    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:33151 USE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36689 UTR2    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:32298 VHS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:33348 VMA21    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:33349 VOA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34984 BioGRID:36114 VPS28    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:31601 VRP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:31469 YKE2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:34984 BioGRID:34104 YKL027W    BioGRID  PubMed Negative Genetic 
    BioGRID:34984 BioGRID:36525 YNG2    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34984 BioGRID:33024 ZRT1    BioGRID  PubMed Negative Genetic 
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    General gene information

    Pathways from BioSystems

    • Sulfur relay system, organism-specific biosystem (from KEGG)
      Sulfur relay system, organism-specific biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
    • Sulfur relay system, conserved biosystem (from KEGG)
      Sulfur relay system, conserved biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    protein tag IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tag IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell budding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		  
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein urmylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA wobble position uridine thiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Urm1p
    NP_012258.1
    • Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2

      Range
      342536..342835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179358.1 → NP_012258.1  Urm1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40554
      Conserved Domains (1) summary
      cd01764
      Location:4 – 99
      Blast Score: 338
      Urm1; Urm1-like ubuitin domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006942.2 DAA08538.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40554.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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