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    PDR11 Pdr11p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854802, updated on 4-Feb-2012
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    Summary

    Gene symbol
    PDR11
    Gene description
    Pdr11p
    Primary source
    SGD:S000001275
    Locus tag
    YIL013C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: IX; NC_001141.2 (328207..332442, complement)
    See PDR11 in MapViewer

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene Mnt3p Neighboring gene Tir3p Neighboring gene Dot5p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    2. The yeast plasma membrane ATP binding cassette (ABC) transporter Aus1: purification, characterization, and the effect of lipids on its activity. Marek M, et al. J Biol Chem, 2011 Jun 17. PMID 21521689.
    3. The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study. Kohut P, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21110944.
    4. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.
    5. Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. Tonikian R, et al. PLoS Biol, 2009 Oct. PMID 19841731.

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the entry of sterol molecules into plasma membrane is not spontaneous but requires assistance of two ABC (ATP-binding cassette) pumps--Aus1p or Pdr11p.
      Title: The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:34978 BioGRID:34416 AUS1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34978 BioGRID:36547 BZZ1    BioGRID  PubMed Two-hybrid 
    BioGRID:34978 BioGRID:31356 EMP70    BioGRID  PubMed PCA 
    BioGRID:34978 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34978 BioGRID:32283 HEM1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34978 BioGRID:32227 HMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:34978 BioGRID:35923 HSP82    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34978 BioGRID:34321 IRA2    BioGRID  PubMed Positive Genetic 
    BioGRID:34978 BioGRID:31627 RPS22B    BioGRID  PubMed Negative Genetic 
    BioGRID:34978 BioGRID:32143 RRP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34978 BioGRID:34334 RTG1    BioGRID  PubMed Negative Genetic 
    BioGRID:34978 BioGRID:33665 SRS2    BioGRID  PubMed Two-hybrid 
    BioGRID:34978 BioGRID:35706 TOM70    BioGRID  PubMed Negative Genetic 
    BioGRID:34978 BioGRID:36689 UTR2    BioGRID  PubMed Negative Genetic 
    BioGRID:34978 BioGRID:33552 YJL206C    BioGRID  PubMed Negative Genetic 
    BioGRID:34978 BioGRID:31421 YLR152C    BioGRID  PubMed Negative Genetic 
    BioGRID:34978 BioGRID:31614 YLR352W    BioGRID  PubMed Negative Genetic 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATPase activity, coupled to transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATPase activity, coupled to transmembrane movement of substances ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    ATP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Names
    Pdr11p
    NP_012252.1
    • ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2

      Range
      328207..332442, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179363.1 → NP_012252.1  Pdr11p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40550
      Conserved Domains (5) summary
      cd03232
      Location:748 – 961
      Blast Score: 729
      ABC_PDR_domain2; The pleiotropic drug resistance-like (PDR) family of ATP-binding cassette (ABC) transporters. PDR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily ...
      cd03233
      Location:45 – 255
      Blast Score: 609
      ABC_PDR_domain1; The pleiotropic drug resistance (PDR) family of ATP-binding cassette (ABC) transporters. PDR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily ...
      TIGR00956
      Location:56 – 1381
      Blast Score: 2256
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
      pfam06422
      Location:585 – 666
      Blast Score: 193
      PDR_CDR; CDR ABC transporter
      cl11417
      Location:1072 – 1283
      Blast Score: 287
      ABC2_membrane; ABC-2 type transporter
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006942.2 DAA08533.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P40550.3 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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