My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    BLZF1 basic leucine zipper nuclear factor 1 [ Homo sapiens ]

    Gene ID: 8548, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    BLZF1provided by HGNC
    Official Full Name
    basic leucine zipper nuclear factor 1provided by HGNC
    Primary source
    HGNC:1065
    Locus tag
    RP1-206D15.1
    See related
    Ensembl:ENSG00000117475; HPRD:16367; MIM:608692; Vega:OTTHUMG00000035453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JEM1; JEM-1; JEM-1s; GOLGIN-45; MGC22497
    Help top of page

    Genomic context

    Location :
    1q24
    Sequence :
    Chromosome: 1; NC_000001.10 (169337194..169365782)
    See BLZF1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 7 Neighboring gene ATPase, Na+/K+ transporting, beta 1 polypeptide Neighboring gene NME/NM23 family member 7 Neighboring gene chromosome 1 open reading frame 114 Neighboring gene uncharacterized LOC100287813 Neighboring gene solute carrier family 19 (thiamine transporter), member 2

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142.
    3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. Ehret GB, et al. Eur J Hum Genet, 2009 Dec. PMID 19536175.
    4. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. Cheung CL, et al. Hum Mol Genet, 2009 Feb 15. PMID 19064610.
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
    2. JEM-1/Golgin-45 is a Golgi localised coiled-coil protein that directly interacts with the active form of the small GTPase rab2, suggesting a function in protein transport.
      Title: A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H2G9 Q9H8Y8 GORASP2    HPRD  PubMed  
    Q9H2G9 P61019 RAB2A    HPRD  PubMed  
    BioGRID:114118 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:114118 BioGRID:117479 GORASP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114118 BioGRID:109309 HCLS1    BioGRID  PubMed Two-hybrid 
    BioGRID:114118 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114118 BioGRID:121792 ZNF410    BioGRID  PubMed Two-hybrid 
    BioGRID:114118 BioGRID:117482 ZZZ3    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		  
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    Golgi organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Golgi to plasma membrane protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    Golgin-45
    Names
    Golgin-45
    JEM-1short protein
    cytoplasmic protein
    p45 basic leucine-zipper nuclear factor
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003666.2 → NP_003657.1  Golgin-45

      Status: VALIDATED

      Source sequence(s)
      AH010039, AK055883, BC020716, BI458959, BI460514
      Consensus CDS
      CCDS1278.1
      UniProtKB/Swiss-Prot
      Q9H2G9
      Related
      ENSP00000327541, OTTHUMP00000033501, ENST00000329281, OTTHUMT00000086110
      Conserved Domains (2) summary
      COG0419
      Location:123 – 281
      Blast Score: 91
      SbcC; ATPase involved in DNA repair [DNA replication, recombination, and repair]
      pfam08227
      Location:181 – 227
      Blast Score: 127
      DASH_Hsk3; DASH complex subunit Hsk3 like

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      169337194..169365782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      140560311..140588820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF272386.1 AAG37822.1
    genomic AF272387.1 AAG37822.1
    genomic AF272388.1 AAG37822.1
    genomic AF273875.1 AAG37821.1
      AAG37822.1
    genomic AF273875.1 AAG37821.1
      AAG37822.1
    genomic AF288162.1 (3756..3995) None
    genomic AL021068.2 (90443..99573) None
    genomic AL356852.11 CAI19239.1
      CAI19240.1
      CAI19241.1
      CAI19242.1
    genomic CH471067.1 EAW90837.1
      EAW90838.1
      EAW90839.1
    mRNA AF288161.1 AAG37835.1
    mRNA AK055883.1 None
    mRNA AK223533.1 BAD97253.1
    mRNA AK291725.1 BAF84414.1
    mRNA AK307151.1 None
    mRNA BC020716.1 AAH20716.1
    mRNA BI458959.1 None
    mRNA BI460514.1 None
    mRNA U79751.1 AAB63110.1
    other-genetic DQ891380.2 ABM82306.1
    other-genetic DQ894557.2 ABM85483.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53EV6 GenPept UniProtKB/TrEMBL:Q53EV6
    Q5T532 GenPept UniProtKB/TrEMBL:Q5T532
    Q5T534 GenPept UniProtKB/TrEMBL:Q5T534
    Q9H2G9.2 GenPept UniProtKB/Swiss-Prot:Q9H2G9
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...