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    BNR1 Bnr1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854647, updated on 21-May-2012
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    Summary

    Gene symbol
    BNR1
    Gene description
    Bnr1p
    Primary source
    SGD:S000001421
    Locus tag
    YIL159W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: IX
    Sequence :
    Chromosome: IX; NC_001141.2 (41825..45952)
    See BNR1 in MapViewer

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Pot1p Neighboring gene Aim20p Neighboring gene Coa1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    2. Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses. Gilmore JM, et al. Mol Cell Proteomics, 2012 Apr. PMID 22199229.
    3. Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation. Liu W, et al. Mol Biol Cell, 2012 Feb. PMID 22160598.
    4. The myosin passenger protein Smy1 controls actin cable structure and dynamics by acting as a formin damper. Chesarone-Cataldo M, et al. Dev Cell, 2011 Aug 16. PMID 21839918.
    5. Cortical actin dynamics driven by formins and myosin V. Yu JH, et al. J Cell Sci, 2011 May 1. PMID 21486946.

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. During polarization, cells change from fast to slow cable dynamics through spatio-temporal regulation of Bni1, Bnr1 and Myo2.
      Title: Cortical actin dynamics driven by formins and myosin V.
    2. Bnr1p has two separable regions that each contribute to its bud neck localization
      Title: The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures.
    3. Yeast expressing the nonlocalized actin nucleating/assembly formin homology (FH) 1-FH2 domains of Bnr1p or Bni1p as the sole formin grow well.
      Title: Polarized growth in budding yeast in the absence of a localized formin.
    4. BNI1 and BNR1 contribute to Bud6p-dependent microtubule-cortex interactions by controlling Bud6p localisation.
      Title: Dissecting the involvement of formins in Bud6p-mediated cortical capture of microtubules in S. cerevisiae.
    5. Bni1 and Bnr1 are regulated by Bud6
      Title: Differential activities and regulation of Saccharomyces cerevisiae formin proteins Bni1 and Bnr1 by Bud6.
    6. different formin isoforms have roles in maintaining stable and dynamic axes in the same yeast cell
      Title: Stable and dynamic axes of polarity use distinct formin isoforms in budding yeast.
    7. Bnr1 was confined to the bud neck and did not exchange with a cytoplasmic pool.
      Title: Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_012107.1 NP_013959.1 FUS2    BIND  PubMed Fus2 interacts with Bnr1. 
    BioGRID:34833 BioGRID:31060 ABP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:34631 ABP140    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:31107 ACT1    BioGRID  PubMed Reconstituted Complex; Synthetic Haploinsufficiency 
    BioGRID:34833 BioGRID:32812 AIM3    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:35267 AIP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:34639 APC5    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:31630 ARC18    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:32027 ARP2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34833 BioGRID:33738 BBC1    BioGRID  PubMed Negative Genetic; Two-hybrid 
    BioGRID:34833 BioGRID:33662 BCK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:36749 BIM1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34833 BioGRID:36930 BMH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:35569 BNI1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Reconstituted Complex; Synthetic Growth Defect; Synthetic Lethality; Synthetic Rescue 
    BioGRID:34833 BioGRID:31798 BUD14    BioGRID  PubMed Phenotypic Suppression; Synthetic Rescue 
    BioGRID:34833 BioGRID:31583 BUD6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:34833 BioGRID:34125 CAP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:31825 CDC13    BioGRID  PubMed Synthetic Rescue 
    BioGRID:34833 BioGRID:31182 CDC14    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:34833 BioGRID:31575 CDC25    BioGRID  PubMed Two-hybrid 
    BioGRID:34833 BioGRID:35540 CLA4    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement 
    BioGRID:34833 BioGRID:31265 COF1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:36625 CTF8    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:31740 DRS2    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:30956 FUS1    BioGRID  PubMed Protein-peptide; Two-hybrid 
    BioGRID:34833 BioGRID:34353 GAL11    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:30970 GBP2    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:32559 GIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:36877 GLC7    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34833 BioGRID:32710 HHF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:35797 HHF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:35204 HOF1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:34833 BioGRID:35923 HSP82    BioGRID  PubMed Synthetic Lethality; Two-hybrid 
    BioGRID:34833 BioGRID:32276 HTB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:32700 HTB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:32127 IPT1    BioGRID  PubMed Positive Genetic 
    BioGRID:34833 BioGRID:34321 IRA2    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:33726 KAR2    BioGRID  PubMed Positive Genetic 
    BioGRID:34833 BioGRID:31063 KIN82    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:34576 LAS17    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:35209 MSN2    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:34006 MYO3    BioGRID  PubMed Phenotypic Enhancement; Two-hybrid 
    BioGRID:34833 BioGRID:35285 MYO5    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Two-hybrid 
    BioGRID:34833 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34833 BioGRID:31467 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34833 BioGRID:35765 OCA2    BioGRID  PubMed Positive Genetic 
    BioGRID:34833 BioGRID:36918 PAB1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:33701 PEP8    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34833 BioGRID:31461 PEX13    BioGRID  PubMed Two-hybrid 
    BioGRID:34833 BioGRID:34517 PFY1    BioGRID  PubMed Dosage Rescue; Phenotypic Enhancement; Two-hybrid 
    BioGRID:34833 BioGRID:34009 PGM1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:35280 PGM2    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:34873 RHO3    BioGRID  PubMed Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:34833 BioGRID:34186 RHO4    BioGRID  PubMed Reconstituted Complex; Synthetic Rescue; Two-hybrid 
    BioGRID:34833 BioGRID:32781 RPG1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:33128 RPS2    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:32449 RVS167    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:31102 SEC53    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:32420 SEM1    BioGRID  PubMed Positive Genetic 
    BioGRID:34833 BioGRID:32692 SLA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:35596 SLA2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34833 BioGRID:36461 SLT2    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement 
    BioGRID:34833 BioGRID:34053 SMY1    BioGRID  PubMed Phenotypic Suppression; Reconstituted Complex; Synthetic Rescue; Two-hybrid 
    BioGRID:34833 BioGRID:32983 SNF5    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:35688 SRV2    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:36075 SSE1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:31710 SST2    BioGRID  PubMed Two-hybrid 
    BioGRID:34833 BioGRID:32010 STP4    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:33575 SWE1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:34833 BioGRID:32772 TAT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:34385 TLG2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34833 BioGRID:35744 TPM1    BioGRID  PubMed Dosage Rescue; Phenotypic Enhancement 
    BioGRID:34833 BioGRID:34853 TPM2    BioGRID  PubMed Dosage Rescue; Phenotypic Enhancement 
    BioGRID:34833 BioGRID:35056 TUB1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34833 BioGRID:32786 UBC4    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:32077 VPS54    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34833 BioGRID:33255 YGR012W    BioGRID  PubMed Negative Genetic 
    BioGRID:34833 BioGRID:37091 YLL017W    BioGRID  PubMed Two-hybrid 
    BioGRID:34833 BioGRID:34146 YPT52    BioGRID  PubMed Negative Genetic 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    profilin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    profilin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    formin-nucleated actin cable assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Bnr1p
    NP_012107.1
    • Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2

      Range
      41825..45952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179507.1 → NP_012107.1  Bnr1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40450
      Conserved Domains (2) summary
      smart00498
      Location:870 – 1325
      Blast Score: 791
      FH2; Formin Homology 2 Domain
      pfam02181
      Location:870 – 1265
      Blast Score: 682
      FH2; Formin Homology 2 Domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006942.2 DAA08393.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40450.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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