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    SSH2 slingshot homolog 2 (Drosophila) [ Homo sapiens ]

    Gene ID: 85464, updated on 11-May-2012
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    Summary

    Official Symbol
    SSH2provided by HGNC
    Official Full Name
    slingshot homolog 2 (Drosophila)provided by HGNC
    Primary source
    HGNC:30580
    See related
    Ensembl:ENSG00000141298; HPRD:09487; MIM:606779; Vega:OTTHUMG00000132752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSH-2; KIAA1725; MGC78588
    Summary
    The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    17q11.2
    Sequence :
    Chromosome: 17; NC_000017.10 (27952965..28257018, complement)
    See SSH2 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13B Neighboring gene G protein-coupled receptor kinase interacting ArfGAP 1 Neighboring gene coronin 6 Neighboring gene ribosomal protein L21 pseudogene 123 Neighboring gene RNA terminal phosphate cyclase-like 1 pseudogene Neighboring gene ribosomal protein L9 pseudogene 30 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene syntaxin 18 pseudogene Neighboring gene RNA, Ro-associated Y4 pseudogene 13

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. Song SY, et al. APMIS, 2010 May. PMID 20477815.
    2. The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. Kligys K, et al. J Biol Chem, 2007 Nov 2. PMID 17848544.
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
    4. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. Soosairajah J, et al. EMBO J, 2005 Feb 9. PMID 15660133.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.
    2. Expression of phosphatase-dead versions of SSH proteins, SSH1, SSH2 & SSH3 results in phosphorylation/inactivation of cofilin, changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in keratinocytes.
      Title: The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q76I76 P60709 ACTB    HPRD  PubMed  
    Q76I76 P23528 CFL1    HPRD  PubMed  
    BioGRID:124548 BioGRID:106575 ACTB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124548 BioGRID:198684 Cfl1    BioGRID  PubMed Biochemical Activity 
    NP_002305.1 LIMK1    BIND  PubMed The shorter isoform, SSH-2S, interacts with LIMK1. 
    NP_003397.1 YWHAZ    BIND  PubMed SSH-2S interacts with 14-3-3-zeta. 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    regulation of lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    protein phosphatase Slingshot homolog 2
    Names
    protein phosphatase Slingshot homolog 2
    SSH-2L
    hSSH-2L
    slingshot 2
    SSH-like protein 2
    NP_203747.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033389.2 → NP_203747.2  protein phosphatase Slingshot homolog 2

      Status: REVIEWED

      Source sequence(s)
      AB099290, BC008941
      Consensus CDS
      CCDS11253.1
      UniProtKB/Swiss-Prot
      Q76I76
      Related
      ENSP00000269033, OTTHUMP00000163634, ENST00000269033, OTTHUMT00000256116
      Conserved Domains (3) summary
      cd00127
      Location:308 – 443
      Blast Score: 391
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:250 – 303
      Blast Score: 174
      DEK_C; DEK C terminal domain
      cd11652
      Location:3 – 236
      Blast Score: 1012
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      27952965..28257018, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      24162366..24466605, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC023389.13 None
    genomic AC087510.7 None
    genomic AC104564.11 None
    genomic AC104982.7 (1545..97770) None
    genomic CH471159.1 EAW51209.1
      EAW51210.1
      EAW51211.1
      EAW51212.1
      EAW51213.1
    mRNA AB051512.1 BAB21816.1
    mRNA AB072358.1 BAB84117.1
    mRNA AB072359.1 BAB84118.1
    mRNA AB099290.1 BAC97813.1
    mRNA AF484838.1 AAL92027.1
    mRNA AK091432.1 BAG52360.1
    mRNA AK094204.1 None
    mRNA AK094429.1 None
    mRNA AK296413.1 BAG59076.1
    mRNA AK308887.1 None
    mRNA BC008941.2 AAH08941.1
    mRNA BC011636.2 AAH11636.2
    mRNA BC068223.1 AAH68223.1
    other-genetic BC166670.1 AAI66670.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76I76.1 GenPept UniProtKB/Swiss-Prot:Q76I76
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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