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TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [ Homo sapiens (human) ]

Gene ID: 85461, updated on 8-May-2016
Official Symbol
TANC1provided by HGNC
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by HGNC
Primary source
HGNC:HGNC:29364
See related
Ensembl:ENSG00000115183 HPRD:18146; MIM:611397; Vega:OTTHUMG00000153945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TANC; ROLSB
Orthologs
Location:
2q24.2
Exon count:
34
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (158968634..159232663)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (159825146..160089170)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transfer RNA-Glu (CTC) 7-1 Neighboring gene olfactory receptor family 7 subfamily E member 90 pseudogene Neighboring gene basic transcription factor 3-like 4 pseudogene 2 Neighboring gene glutathione S-transferase mu 3 pseudogene 2 Neighboring gene uncharacterized LOC105373716 Neighboring gene microRNA 6888 Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene uncharacterized LOC101929461 Neighboring gene bromodomain adjacent to zinc finger domain 2B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.
NHGRI GWA Catalog
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13360, FLJ41166, KIAA1728

Gene Ontology Provided by GOA

Process Evidence Code Pubs
dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein TANC1
Names
TPR domain, ankyrin-repeat and coiled-coil-containing
rolling pebbles homolog B
tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145909.1NP_001139381.1  protein TANC1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC009307, AC010093, AL833258, BC037329, BC150597, DA226268
    UniProtKB/Swiss-Prot
    Q9C0D5
    UniProtKB/TrEMBL
    B9EK39
    Conserved Domains (5) summary
    cd00204
    Location:11001223
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11081200
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:12821359
    TPR_11; TPR repeat
    cl21476
    Location:761862
    alkPPc; Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. ...
    sd00006
    Location:12841309
    TPR; TPR repeat [structural motif]
  2. NM_033394.2NP_203752.2  protein TANC1 isoform 1

    See identical proteins and their annotated locations for NP_203752.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC009307, AC010093, AK128859, AL833258, BC037329, BC150597, BX648327
    Consensus CDS
    CCDS42766.1
    UniProtKB/Swiss-Prot
    Q9C0D5
    UniProtKB/TrEMBL
    B9EK39
    Related
    ENSP00000263635, OTTHUMP00000204699, ENST00000263635, OTTHUMT00000333135
    Conserved Domains (4) summary
    cd00204
    Location:11081231
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11161208
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13381401
    TPR_11; TPR repeat
    sd00006
    Location:12921317
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    158968634..159232663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512055.1XP_011510357.1  

    Conserved Domains (4) summary
    cd00204
    Location:11001223
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11081200
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13301393
    TPR_11; TPR repeat
    sd00006
    Location:12841309
    TPR; TPR repeat [structural motif]
  2. XM_011512058.1XP_011510360.1  

    UniProtKB/Swiss-Prot
    Q9C0D5
    Conserved Domains (4) summary
    cd00204
    Location:10021125
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10101102
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:12321295
    TPR_11; TPR repeat
    sd00006
    Location:11861211
    TPR; TPR repeat [structural motif]
  3. XM_006712812.2XP_006712875.1  

    Conserved Domains (4) summary
    cd00204
    Location:10731196
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10811173
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13031366
    TPR_11; TPR repeat
    sd00006
    Location:12571282
    TPR; TPR repeat [structural motif]
  4. XM_011512048.1XP_011510350.1  

    Conserved Domains (4) summary
    cd00204
    Location:11321255
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11401232
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13621425
    TPR_11; TPR repeat
    sd00006
    Location:13161341
    TPR; TPR repeat [structural motif]
  5. XM_011512051.1XP_011510353.1  

    See identical proteins and their annotated locations for XP_011510353.1

    Conserved Domains (4) summary
    cd00204
    Location:11261249
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11341226
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13561419
    TPR_11; TPR repeat
    sd00006
    Location:13101335
    TPR; TPR repeat [structural motif]
  6. XM_011512053.1XP_011510355.1  

    See identical proteins and their annotated locations for XP_011510355.1

    Conserved Domains (4) summary
    cd00204
    Location:11261249
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11341226
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13561419
    TPR_11; TPR repeat
    sd00006
    Location:13101335
    TPR; TPR repeat [structural motif]
  7. XM_006712810.2XP_006712873.1  

    See identical proteins and their annotated locations for XP_006712873.1

    UniProtKB/Swiss-Prot
    Q9C0D5
    Conserved Domains (4) summary
    cd00204
    Location:11081231
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11161208
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13381401
    TPR_11; TPR repeat
    sd00006
    Location:12921317
    TPR; TPR repeat [structural motif]
  8. XM_011512052.1XP_011510354.1  

    See identical proteins and their annotated locations for XP_011510354.1

    Conserved Domains (4) summary
    cd00204
    Location:11261249
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11341226
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13561419
    TPR_11; TPR repeat
    sd00006
    Location:13101335
    TPR; TPR repeat [structural motif]
  9. XM_011512046.1XP_011510348.1  

    Conserved Domains (4) summary
    cd00204
    Location:11361259
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11441236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13661429
    TPR_11; TPR repeat
    sd00006
    Location:13201345
    TPR; TPR repeat [structural motif]
  10. XM_011512049.1XP_011510351.1  

    Conserved Domains (4) summary
    cd00204
    Location:11291252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11371229
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13591422
    TPR_11; TPR repeat
    sd00006
    Location:13131338
    TPR; TPR repeat [structural motif]
  11. XM_011512056.1XP_011510358.1  

    Conserved Domains (4) summary
    cd00204
    Location:10481171
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10561148
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:12781341
    TPR_11; TPR repeat
    sd00006
    Location:12321257
    TPR; TPR repeat [structural motif]
  12. XM_011512047.1XP_011510349.1  

    Conserved Domains (4) summary
    cd00204
    Location:11351258
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11431235
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13651428
    TPR_11; TPR repeat
    sd00006
    Location:13191344
    TPR; TPR repeat [structural motif]
  13. XM_011512050.1XP_011510352.1  

    Conserved Domains (4) summary
    cd00204
    Location:11281251
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11361228
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13581421
    TPR_11; TPR repeat
    sd00006
    Location:13121337
    TPR; TPR repeat [structural motif]
  14. XM_011512057.1XP_011510359.1  

    Conserved Domains (4) summary
    cd00204
    Location:10301153
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10381130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:12601323
    TPR_11; TPR repeat
    sd00006
    Location:12141239
    TPR; TPR repeat [structural motif]
  15. XM_011512060.1XP_011510362.1  

    Conserved Domains (4) summary
    cd00204
    Location:9421065
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9501042
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:11721235
    TPR_11; TPR repeat
    sd00006
    Location:11261151
    TPR; TPR repeat [structural motif]
  16. XM_011512054.1XP_011510356.1  

    Conserved Domains (4) summary
    cd00204
    Location:11011224
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11091201
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13311394
    TPR_11; TPR repeat
    sd00006
    Location:12851310
    TPR; TPR repeat [structural motif]
  17. XM_005246918.3XP_005246975.1  

    Conserved Domains (4) summary
    cd00204
    Location:11181241
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11261218
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:13481411
    TPR_11; TPR repeat
    sd00006
    Location:13021327
    TPR; TPR repeat [structural motif]
  18. XM_006712814.2XP_006712877.1  

    Conserved Domains (4) summary
    cd00204
    Location:9241047
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9321024
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:11541217
    TPR_11; TPR repeat
    sd00006
    Location:11081133
    TPR; TPR repeat [structural motif]
  19. XM_011512059.1XP_011510361.1  

    Conserved Domains (4) summary
    cd00204
    Location:9441067
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9521044
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:11741237
    TPR_11; TPR repeat
    sd00006
    Location:11281153
    TPR; TPR repeat [structural motif]
  20. XM_011512062.1XP_011510364.1  

    Conserved Domains (4) summary
    cd00204
    Location:801924
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:809901
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:10311094
    TPR_11; TPR repeat
    sd00006
    Location:9851010
    TPR; TPR repeat [structural motif]
  21. XM_011512061.1XP_011510363.1  

    Conserved Domains (4) summary
    cd00204
    Location:8981021
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:906998
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:11281191
    TPR_11; TPR repeat
    sd00006
    Location:10821107
    TPR; TPR repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    159831431..160095361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)