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MCH5 riboflavin transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 854483, updated on 11-Apr-2024

Summary

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Gene symbol
MCH5
Gene description
riboflavin transporter
Primary source
SGD:S000005833
Locus tag
YOR306C
See related
AllianceGenome:SGD:S000005833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables riboflavin transmembrane transporter activity. Involved in riboflavin transport. Located in plasma membrane. Orthologous to several human genes including SLC16A10 (solute carrier family 16 member 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (889867..891432, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bil1p Neighboring gene Rrg7p Neighboring gene Sly41p Neighboring gene U4/U6-U5 snRNP complex subunit SNU66

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The monocarboxylate transporter homolog Mch5p catalyzes riboflavin (vitamin B2) uptake in Saccharomyces cerevisiae. Reihl P, et al. J Biol Chem, 2005 Dec 2. PMID 16204239
  2. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
  3. Disruption and basic functional analysis of six novel ORFs of chromosome XV from Saccharomyces cerevisiae. Lafuente MJ, et al. Yeast, 1999 Jul. PMID 10407273
  4. Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity. Wu MJ, et al. Biometals, 2012 Jun. PMID 22403011
  5. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae
    Title: The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae.
  2. S. cerevisiae has a mechanism to sense riboflavin and avert riboflavin deficiency by increasing the expression of the plasma membrane transporter MCH5
    Title: The monocarboxylate transporter homolog Mch5p catalyzes riboflavin (vitamin B2) uptake in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables riboflavin transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in riboflavin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in riboflavin transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
riboflavin transporter
NP_014951.4
  • Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    889867..891432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183726.4 → NP_014951.4  TPA: riboflavin transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014951.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W306, Q08777
    UniProtKB/TrEMBL
    A0A8H4BWK5, C7GNV4, G2WNH3, N1NYX5
    Conserved Domains (1) summary
    cd17352
    Location:106 → 510
    MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08777.2

Gene LinkOut

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