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    UAF30 Uaf30p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854470, updated on 21-Jan-2012
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    Summary

    Gene symbol
    UAF30
    Gene description
    Uaf30p
    Primary source
    SGD:S000005821
    Locus tag
    YOR295W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: XV; NC_001147.6 (869208..869894)
    See UAF30 in MapViewer

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Rrs1p Neighboring gene hypothetical protein Neighboring gene Tim18p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Magtanong L, et al. Nat Biotechnol, 2011 May 15. PMID 21572441.
    2. The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Bernstein KA, et al. Mol Biol Cell, 2011 May. PMID 21372173.
    3. A global protein kinase and phosphatase interaction network in yeast. Breitkreutz A, et al. Science, 2010 May 21. PMID 20489023.
    4. Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae. Libuda DE, et al. Genetics, 2010 Apr. PMID 20139344.
    5. Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. Batisse J, et al. J Biol Chem, 2009 Dec 11. PMID 19840948.

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The results show that Uaf30p is a key targeting factor for the UAF complex that facilitates activation of a large proportion of rDNA genes in the tandem array.
      Title: Transcription of multiple yeast ribosomal DNA genes requires targeting of UAF to the promoter by Uaf30.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:34683 BioGRID:31107 ACT1    BioGRID  PubMed Synthetic Haploinsufficiency 
    BioGRID:34683 BioGRID:33145 ARC1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:36749 BIM1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34683 BioGRID:36231 BRR1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:34955 CKA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34683 BioGRID:34460 CKA2    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:36302 CTF4    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34683 BioGRID:34479 DIA2    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34683 BioGRID:35305 ECM16    BioGRID  PubMed Negative Genetic 
    BioGRID:34683 BioGRID:32687 FMT1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:35691 FPR1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:36728 GIM4    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:34683 BioGRID:32205 GIR2    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:36877 GLC7    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34683 BioGRID:32277 HTA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34683 BioGRID:32276 HTB1    BioGRID  PubMed Negative Genetic 
    BioGRID:34683 BioGRID:33845 JSN1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:36056 KAP120    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:34683 BioGRID:33080 KEM1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:32495 LRS4    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:31742 LTE1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34683 BioGRID:34110 MAK11    BioGRID  PubMed Negative Genetic 
    BioGRID:34683 BioGRID:33116 MRM2    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34683 BioGRID:32674 NCL1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:34361 NOP12    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:34952 NOT3    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:34683 BioGRID:31898 NRP1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:31247 ORC3    BioGRID  PubMed Dosage Rescue 
    BioGRID:34683 BioGRID:32642 PTH2    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:34021 RAD27    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34683 BioGRID:31414 RMP1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:35511 RPD3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:34683 BioGRID:32629 RPS8A    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:31409 RRN5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34683 BioGRID:31488 RSA3    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:32420 SEM1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:35368 SGS1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34683 BioGRID:36420 SHU1    BioGRID  PubMed Dosage Growth Defect; Phenotypic Suppression 
    BioGRID:34683 BioGRID:31352 SIC1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34683 BioGRID:32807 SIF2    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:34683 BioGRID:33043 SKI8    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:34683 BioGRID:35394 SKY1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:32561 SMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34683 BioGRID:30946 SRO9    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:33665 SRS2    BioGRID  PubMed Phenotypic Suppression; Synthetic Growth Defect 
    BioGRID:34683 BioGRID:33763 SUI2    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:32225 SUP35    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:36026 TGS1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:34398 TOP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34683 BioGRID:31845 TRM8    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:31836 UGA4    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:34683 BioGRID:34118 URB1    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:32670 YBL028C    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:35675 YCK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:34683 BioGRID:33501 YGR250C    BioGRID  PubMed Positive Genetic 
    BioGRID:34683 BioGRID:31469 YKE2    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:34683 BioGRID:35804 YNL022C    BioGRID  PubMed Positive Genetic 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA polymerase I upstream control element sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription of nuclear large rRNA transcript from RNA polymerase I promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    RNA polymerase I upstream activating factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Uaf30p
    NP_014938.1
    • Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6

      Range
      869208..869894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183714.1 → NP_014938.1  Uaf30p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q08747
      Conserved Domains (3) summary
      COG5531
      Location:1 – 228
      Blast Score: 492
      COG5531; SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]
      cl02489
      Location:120 – 195
      Blast Score: 283
      SWIB; SWIB/MDM2 domain
      pfam08766
      Location:6 – 51
      Blast Score: 79
      DEK_C; DEK C terminal domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006948.2 DAA11060.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q08747.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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