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    RPN8 Rpn8p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854435, updated on 4-Feb-2012
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    Summary

    Gene symbol
    RPN8
    Gene description
    Rpn8p
    Primary source
    SGD:S000005787
    Locus tag
    YOR261C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: XV; NC_001147.6 (815915..816931, complement)
    See RPN8 in MapViewer

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rpt4p Neighboring gene Gcd1p Neighboring gene hypothetical protein Neighboring gene Dse3p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4. Mitchell L, et al. PLoS One, 2011. PMID 21984913.
    2. Novel interactions between actin and the proteasome revealed by complex haploinsufficiency. Haarer B, et al. PLoS Genet, 2011 Sep. PMID 21966278.
    3. The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle. Sakata E, et al. Mol Cell, 2011 Jun 10. PMID 21658604.
    4. Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. Gomez TA, et al. BMC Biol, 2011 May 31. PMID 21627799.
    5. A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Ziv I, et al. Mol Cell Proteomics, 2011 May. PMID 21427232.

    See all (44) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:34651 BioGRID:31107 ACT1    BioGRID  PubMed Synthetic Haploinsufficiency 
    BioGRID:34651 BioGRID:32027 ARP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:35876 BRE5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:32323 CIA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:34084 CSE4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:32415 EAF1    BioGRID  PubMed Dosage Lethality 
    BioGRID:34651 BioGRID:36200 EAF3    BioGRID  PubMed Dosage Growth Defect 
    BioGRID:34651 BioGRID:36712 EAF5    BioGRID  PubMed Dosage Lethality 
    BioGRID:34651 BioGRID:33837 EAF6    BioGRID  PubMed Dosage Growth Defect 
    BioGRID:34651 BioGRID:35690 EAF7    BioGRID  PubMed Dosage Lethality 
    BioGRID:34651 BioGRID:36392 ECM29    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:34651 BioGRID:32570 FPR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:34242 HRT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:32967 HSM3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:34651 BioGRID:36695 HYP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:33776 LSM8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:32836 MEC1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34651 BioGRID:31309 MLH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:36811 MOT2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:34651 BioGRID:35750 MSK1    BioGRID  PubMed Two-hybrid 
    BioGRID:34651 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34651 BioGRID:33484 NAS6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:34651 BioGRID:32018 NAT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:34604 NPT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:36744 PRE1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:34747 PRE10    BioGRID  PubMed Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:36269 PRE2    BioGRID  PubMed Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:33756 PRE3    BioGRID  PubMed Negative Genetic 
    BioGRID:34651 BioGRID:31208 PRE4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:35494 PRE5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:34364 PRE6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:32656 PRE7    BioGRID  PubMed Positive Genetic 
    BioGRID:34651 BioGRID:35051 PRE8    BioGRID  PubMed Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:33383 PRE9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:34553 PUP1    BioGRID  PubMed Affinity Capture-Western; Positive Genetic 
    BioGRID:34651 BioGRID:33504 PUP2    BioGRID  PubMed Affinity Capture-Western; Negative Genetic 
    BioGRID:34651 BioGRID:36692 RAD23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:36924 RAD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:35589 RAD50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:36030 RAD53    BioGRID  PubMed Dosage Rescue 
    BioGRID:34651 BioGRID:33096 RCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:36458 RPN1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:34651 BioGRID:36634 RPN10    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:34651 BioGRID:31152 RPN11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; PCA; Phenotypic Suppression; Positive Genetic; Reconstituted Complex; Two-hybrid 
    BioGRID:34651 BioGRID:31210 RPN12    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:34651 BioGRID:31680 RPN13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:33241 RPN14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:34651 BioGRID:34917 RPN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:36755 RPN3    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:34651 BioGRID:31914 RPN5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; PCA; Two-hybrid 
    BioGRID:34651 BioGRID:31965 RPN6    BioGRID  PubMed Affinity Capture-MS; Co-purification; PCA; Positive Genetic 
    BioGRID:34651 BioGRID:36274 RPN7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Rescue 
    BioGRID:34651 BioGRID:32485 RPN9    BioGRID  PubMed Affinity Capture-MS; PCA; Two-hybrid 
    BioGRID:34651 BioGRID:33991 RPT1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Rescue 
    BioGRID:34651 BioGRID:32047 RPT2    BioGRID  PubMed Affinity Capture-MS; Synthetic Rescue 
    BioGRID:34651 BioGRID:32456 RPT3    BioGRID  PubMed Affinity Capture-MS; Positive Genetic 
    BioGRID:34651 BioGRID:34649 RPT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:34513 RPT5    BioGRID  PubMed Affinity Capture-MS; Positive Genetic 
    BioGRID:34651 BioGRID:33200 RPT6    BioGRID  PubMed Affinity Capture-MS; Positive Genetic 
    BioGRID:34651 BioGRID:33235 SCL1    BioGRID  PubMed Negative Genetic 
    BioGRID:34651 BioGRID:32420 SEM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:35369 SPG5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:32573 SPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:35004 SQT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:31160 UBP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:32658 URA7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34651 BioGRID:36525 YNG2    BioGRID  PubMed Dosage Lethality 
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    General gene information

    Homology

    • Homologs of the RPN8 gene: The RPN8 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice, and P.falciparum.

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Rpn8p
    NP_014904.1
    • Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6

      Range
      815915..816931, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183680.1 → NP_014904.1  Rpn8p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q08723
      Conserved Domains (2) summary
      cd08062
      Location:6 – 303
      Blast Score: 1069
      MPN_RPN7_8; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
      PLN03246
      Location:6 – 299
      Blast Score: 802
      PLN03246; 26S proteasome regulatory subunit; Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006948.2 DAA11028.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q08723.3 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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