DCLK3 doublecortin-like kinase 3 [Homo sapiens] - Gene

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Summary

Official Symbol: DCLK3provided by HGNC
Official Full Name: doublecortin-like kinase 3provided by HGNC
Primary source: HGNC:19005
Locus tag: hCG_16695
See related: Ensembl:ENSG00000163673; MIM:613167; Vega:OTTHUMG00000155805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLR; DCK3; DCDC3C; DCAMKL3; KIAA1765

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Genomic context

Location :: 3p22.2

Sequence :: Chromosome: 3; NC_000003.11 (36753913..36781352, complement)

See DCLK3 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase DCLK3

Names: serine/threonine-protein kinase DCLK3; CLICK-I,II-related; doublecortin and CaM kinase-like 3; doublecortin-like and CAM kinase-like 3; doublecortin domain-containing protein 3C

NP_208382.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033403.1 → NP_208382.1 serine/threonine-protein kinase DCLK3

Status: VALIDATED

Source sequence(s)

AB051552, AC105749, AK122988, DB075681, DR000236

Consensus CDS

CCDS43064.1

UniProtKB/TrEMBL

B3KVM3

UniProtKB/Swiss-Prot

Q9C098

Related

ENSP00000394484, OTTHUMP00000208673, ENST00000416516, OTTHUMT00000341727

Conserved Domains (2) summary

cd05123
Location:362 – 612
Blast Score: 629

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:356 – 613
Blast Score: 854

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

36753913..36781352, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

36694656..36722087, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC105749.2 (76496..129214)	None
genomic	CH471055.1	EAW64476.1
mRNA	AB051552.1	BAB21856.1
mRNA	AK122988.1	BAG53835.1
mRNA	DB075681.1	None
mRNA	DR000236.1	None