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    SEC63 Sec63p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854428, updated on 19-May-2012
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    Summary

    Gene symbol
    SEC63
    Gene description
    Sec63p
    Primary source
    SGD:S000005780
    Locus tag
    YOR254C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PTL1
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    Genomic context

    Location :
    chromosome: XV
    Sequence :
    Chromosome: XV; NC_001147.6 (805032..807023, complement)
    See SEC63 in MapViewer

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tma16p Neighboring gene Nat5p Neighboring gene Osw1p Neighboring gene Tre2p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    2. Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Nakatogawa H, et al. Autophagy, 2012 Feb 1. PMID 22240591.
    3. The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2. Schillewaert S, et al. Mol Cell Biol, 2012 Jan. PMID 22083961.
    4. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    5. The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation. Meiringer CT, et al. J Biol Chem, 2011 Jul 15. PMID 21550981.

    See all (52) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The introduction of Sec63 improves secretory proteins in Pichia pastoris secretion 4-7 times.
      Title: Enhanced secretion of heterologous proteins in Pichia pastoris following overexpression of Saccharomyces cerevisiae chaperone proteins.
    2. the Sec63p BRL domain is required for assembly of functional endoplasmic reticulum translocons
      Title: The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:34644 BioGRID:33282 ACB1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36839 AIM11    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:33709 AIM22    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:34350 AIM39    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35958 ALG5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34405 ALG6    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34466 ALG8    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33512 APL6    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34950 APQ12    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:31630 ARC18    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33312 ART5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35832 ATG3    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32625 ATG8    BioGRID  PubMed Co-localization 
    BioGRID:34644 BioGRID:35059 ATP18    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35722 AVT4    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:32615 AVT5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36291 AXL1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35415 BCH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33662 BCK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32897 BEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31671 BER1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34429 BUB3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31123 BUD27    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31040 BUD31    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36666 CAN1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:31487 CCC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33470 CCH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31383 CCW12    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31499 CDC42    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35376 CIK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34460 CKA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:34644 BioGRID:33931 CNB1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31772 CNE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35773 COG5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33240 COG7    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36377 COS8    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:35835 CSE2    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:34084 CSE4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34644 BioGRID:31360 CSF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36001 CTI6    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35442 CUE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33220 CWH41    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:30996 CWH43    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34046 CYT2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31397 DCN1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31753 DEP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34699 DGK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33480 DIE2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34980 DOT5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31740 DRS2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32878 DTR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32415 EAF1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32701 ECM15    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32780 ECM33    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36142 EGD1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36627 EGD2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36095 ELP3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35743 EOS1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32473 ERD1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:35380 ERG2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31331 ERG3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35186 ERG5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35161 ERG6    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31199 ERJ5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31011 FEN2    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:31604 FKS1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:31813 FLO1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31270 FPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34710 FRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:34644 BioGRID:31738 FRT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:34644 BioGRID:33449 FYV8    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35487 GAS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31779 GEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35312 GID8    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35676 GIM3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32151 GIS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34342 GPD2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36333 GPH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36104 GPI2    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:33656 GSH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33666 GWT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34644 BioGRID:31115 HAC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33831 HOC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36499 HTD2    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:35919 HUT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31643 IKI3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36513 IRE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34151 IRS4    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32548 ITR1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:33726 KAR2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Negative Genetic; Reconstituted Complex; Synthetic Lethality; Synthetic Rescue 
    BioGRID:34644 BioGRID:34194 LAS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34644 BioGRID:33692 LAS21    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35517 LEM3    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:34058 LHS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32002 MBP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35532 MCK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34080 MDM35    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31595 MID2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34624 MKK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35345 MLH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31245 MMM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32296 MNN10    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32718 MNN2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34312 MSH2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32246 MSS116    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:35276 MUB1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34644 BioGRID:36521 NAM8    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33045 NCS6    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36429 NEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32052 NHP10    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32203 NUM1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:31971 NUR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35724 OCA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33829 OPI3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35150 OST6    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34196 PAM17    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33344 PCP1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:33031 PDE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33701 PEP8    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34421 PET127    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33380 PHB1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33483 PHB2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35082 PHO84    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:35300 PKR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36143 PMA2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31966 PMT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35153 PPZ1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36269 PRE2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31208 PRE4    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35494 PRE5    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34364 PRE6    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33383 PRE9    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36623 PTH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34117 PUT3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31958 QRI7    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35379 RAD14    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:30977 RER1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32956 RGD1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33203 RIM8    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34004 RMA1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32924 ROT2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31854 RPL35A    BioGRID  PubMed Synthetic Rescue 
    BioGRID:34644 BioGRID:31269 RPL8B    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:36634 RPN10    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32035 RPN4    BioGRID  PubMed Synthetic Rescue 
    BioGRID:34644 BioGRID:31110 RPO41    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31978 RPS16B    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32502 RPS17B    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:35103 RPS1B    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34188 RPS21A    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36451 RPS27B    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31997 RPS29B    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33991 RPT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:34644 BioGRID:31619 RSC2    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32996 RTF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34334 RTG1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33027 RTG2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33708 RTT101    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31249 RTT109    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34611 RUD3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33953 SAC1    BioGRID  PubMed Negative Genetic; Positive Genetic 
    BioGRID:34644 BioGRID:35235 SAM37    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35441 SAP30    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36832 SBH1    BioGRID  PubMed Co-purification; Negative Genetic 
    BioGRID:34644 BioGRID:35392 SCJ1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:33235 SCL1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33125 SCS3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35451 SCS7    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34908 SDS3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35013 SEC11    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32549 SEC20    BioGRID  PubMed Co-localization 
    BioGRID:34644 BioGRID:31699 SEC39    BioGRID  PubMed Co-localization 
    BioGRID:34644 BioGRID:31638 SEC61    BioGRID  PubMed Affinity Capture-Western; Co-purification; Dosage Rescue; Negative Genetic; PCA 
    BioGRID:34644 BioGRID:36087 SEC62    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Dosage Rescue; PCA; Two-hybrid 
    BioGRID:34644 BioGRID:34644 SEC63    BioGRID  PubMed Two-hybrid 
    BioGRID:34644 BioGRID:32871 SEC66    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Dosage Rescue; Negative Genetic; PCA 
    BioGRID:34644 BioGRID:31558 SEC72    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Negative Genetic; PCA 
    BioGRID:34644 BioGRID:32132 SED1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34162 SET3    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:30971 SGF29    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36863 SHO1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:34369 SIL1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:34644 BioGRID:32566 SLF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32024 SLM3    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34696 SLY41    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35100 SMA2    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:33481 SMI1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32529 SNF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36435 SOD2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32059 SOK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33767 SPC1    BioGRID  PubMed Negative Genetic; PCA 
    BioGRID:34644 BioGRID:35112 SPC2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36698 SPF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35136 SRC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32977 SSH1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:32142 SSS1    BioGRID  PubMed Co-purification 
    BioGRID:34644 BioGRID:33873 STE24    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32363 SUM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36123 SUR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31632 SUR4    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32926 SWC5    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:33575 SWE1    BioGRID  PubMed Biochemical Activity 
    BioGRID:34644 BioGRID:32182 SWF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32457 SXM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35736 TCB2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35322 TIF34    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34644 BioGRID:34385 TLG2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31224 TPO1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:31845 TRM8    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34511 TRS33    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32166 TRS85    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36544 UBA4    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32786 UBC4    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35193 UBC7    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34644 BioGRID:31941 UBP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35156 UBX2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:31855 UFD2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32298 VHS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32103 VMS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36439 VPS29    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33606 VPS35    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36346 VPS4    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32136 VPS41    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:34152 VPS51    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36729 WBP1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:32841 YBR141C    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32916 YBR219C    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32917 YBR220C    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:36568 YCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:34644 BioGRID:31062 YCR090C    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32290 YDR239C    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:34068 YET1    BioGRID  PubMed Affinity Capture-Western; Synthetic Growth Defect 
    BioGRID:34644 BioGRID:31989 YET3    BioGRID  PubMed Affinity Capture-Western; Negative Genetic; Synthetic Growth Defect 
    BioGRID:34644 BioGRID:36382 YHL042W    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:36573 YHR140W    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:33715 YJL043W    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33706 YJL049W    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33685 YJL070C    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33600 YJL160C    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:33808 YJR054W    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:34104 YKL027W    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32808 YMC2    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:32881 YPC1    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:34679 YPK9    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:35949 YPL264C    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:36259 YPR089W    BioGRID  PubMed Negative Genetic 
    BioGRID:34644 BioGRID:33951 YRA2    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:32755 YRO2    BioGRID  PubMed PCA 
    BioGRID:34644 BioGRID:32815 YSA1    BioGRID  PubMed Positive Genetic 
    BioGRID:34644 BioGRID:36589 YSP1    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    Pathways from BioSystems

    • Protein export, organism-specific biosystem (from KEGG)
      Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • Protein export, conserved biosystem (from KEGG)
      Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    SRP-dependent cotranslational protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cytosol to ER transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    posttranslational protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    posttranslational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Sec62/Sec63 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Sec63p
    NP_014897.1
    • Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6

      Range
      805032..807023, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183673.1 → NP_014897.1  Sec63p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P14906
      Conserved Domains (3) summary
      COG5407
      Location:1 – 621
      Blast Score: 1966
      SEC63; Preprotein translocase subunit Sec63 [Intracellular trafficking and secretion]
      cd06257
      Location:125 – 185
      Blast Score: 171
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00973
      Location:268 – 430
      Blast Score: 139
      Sec63; Sec63 Brl domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006948.2 DAA11021.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14906.2 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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