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    DOCK7 dedicator of cytokinesis 7 [ Homo sapiens ]

    Gene ID: 85440, updated on 11-May-2012

    Summary

    Official Symbol
    DOCK7provided by HGNC
    Official Full Name
    dedicator of cytokinesis 7provided by HGNC
    Primary source
    HGNC:19190
    Locus tag
    RP4-740B20.2
    See related
    Ensembl:ENSG00000116641; HPRD:16833; Vega:OTTHUMG00000013131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIR2; KIAA1771

    Genomic context

    Location :
    1p31.3
    Sequence :
    Chromosome: 1; NC_000001.10 (62920397..63153969, complement)
    See DOCK7 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 4 Neighboring gene ubiquitin specific peptidase 1 Neighboring gene uncharacterized LOC100507664 Neighboring gene angiopoietin-like 3 Neighboring gene ribosomal protein L13a pseudogene 9 Neighboring gene ATG4 autophagy related 4 homolog C (S. cerevisiae) Neighboring gene long intergenic non-protein coding RNA 466

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96N67 P60953 CDC42    HPRD  PubMed  
    Q96N67 P61586 RHOA    HPRD  PubMed  
    Q96N67 P61981 YWHAG    HPRD  PubMed  
    BioGRID:124527 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:107070 BCL2L1    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:109143 GRB7    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:109212 GTF2A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:110438 MLH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:111508 PPP2CB    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:116283 RPP14    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:112506 SNCA    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:112540 SOX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:124527 BioGRID:113099 TSC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:124527 BioGRID:116078 USP19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124527 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rac GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of Rac GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon TAS
    Traceable Author Statement
    more info
    PubMed 
    basal part of cell TAS
    Traceable Author Statement
    more info
    PubMed 
    growth cone TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection TAS
    Traceable Author Statement
    more info
    PubMed 
    colocalizes_with signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dedicator of cytokinesis protein 7
    Names
    dedicator of cytokinesis protein 7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033407.2NP_212132.2  dedicator of cytokinesis protein 7

      Status: VALIDATED

      Source sequence(s)
      AB051558, AK055296, AK055401, AK125049, BG190976, BG205481, BG207092, BU943181, BX485492
      Consensus CDS
      CCDS30734.1
      UniProtKB/Swiss-Prot
      Q96N67
      UniProtKB/TrEMBL
      Q96NI0
      Related
      ENSP00000340742, OTTHUMP00000015338, ENST00000340370, OTTHUMT00000036806
      Conserved Domains (3) summary
      pfam11878
      Location:65159
      Blast Score: 353
      DUF3398; Domain of unknown function (DUF3398)
      cd08696
      Location:560737
      Blast Score: 896
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam06920
      Location:18992076
      Blast Score: 750
      Ded_cyto; Dedicator of cytokinesis

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      62920397..63153969, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      61032437..61265923, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC096946.2 None
    genomic AC103923.2 None
    genomic AL138847.14 CAI22995.1
      CAI22996.1
    genomic AL451044.7 CAI13104.1
      CAI13105.1
    mRNA AB051558.1 BAB21862.1
    mRNA AK022097.1 None
    mRNA AK055296.1 None
    mRNA AK055401.1 BAB70917.1
    mRNA AK055493.1 BAB70933.1
    mRNA AK055905.1 BAB71042.1
    mRNA AK091479.1 BAG52372.1
    mRNA AK125049.1 BAC86032.1
    mRNA AK292640.1 BAF85329.1
    mRNA AK299737.1 BAG61632.1
    mRNA BC016392.1 AAH16392.2
    mRNA BC018075.1 None
    mRNA BC018076.1 None
    mRNA BC041813.1 None
    mRNA BC112387.1 AAI12388.1
    mRNA BG190976.1 None
    mRNA BG205481.1 None
    mRNA BG207092.1 None
    mRNA BU943181.1 None
    mRNA BX485492.1 None
    mRNA DQ118679.1 AAZ38451.1
    mRNA DQ118680.1 AAZ38452.1
    mRNA DQ309763.1 ABC33725.1
    mRNA DQ341187.1 ABC68221.1
    other-genetic BC172250.1 AAI72250.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96N67.4 GenPept UniProtKB/Swiss-Prot:Q96N67
    Q96NI0 GenPept UniProtKB/TrEMBL:Q96NI0

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