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LAS17 actin-binding protein LAS17 [ Saccharomyces cerevisiae S288c ]

Gene ID: 854353, updated on 16-Jan-2016
Gene symbol
LAS17
Gene description
actin-binding protein LAS17
Primary source
SGD:S000005707
Locus tag
YOR181W
Gene type
protein coding
RNA name
actin-binding protein LAS17
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BEE1
See LAS17 in MapViewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (675939..677840)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene cleavage polyadenylation factor subunit SYC1 Neighboring gene putative dodecenoyl-CoA isomerase DCI1 Neighboring gene ribosomal 40S subunit protein S30B Neighboring gene Fyv12p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
actin cortical patch assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
actin cortical patch localization IGI
Inferred from Genetic Interaction
more info
PubMed 
actin cortical patch localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
actin cortical patch IDA
Inferred from Direct Assay
more info
PubMed 
actin cortical patch IEA
Inferred from Electronic Annotation
more info
 
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
Names
actin-binding protein LAS17
NP_014824.1
  • Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    675939..677840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183600.1NP_014824.1  actin-binding protein LAS17 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_014824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q12446
    Conserved Domains (1) summary
    cd01205
    Location:23123
    EVH1_WASP-like; WASP family proteins EVH1 domain