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LAS17 Las17p [ Saccharomyces cerevisiae S288c ]

Gene ID: 854353, updated on 6-Jul-2014
Gene symbol
LAS17
Gene description
Las17p
Primary source
SGD:S000005707
Locus tag
YOR181W
Gene type
protein coding
RNA name
Las17p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BEE1
See LAS17 in MapViewer
Location:
chromosome: XV
Exon count :
1
Sequence:
Chromosome: XV; NC_001147.6 (675939..677840)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Syc1p Neighboring gene putative dodecenoyl-CoA isomerase DCI1 Neighboring gene ribosomal 40S subunit protein S30B Neighboring gene Fyv12p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
actin cortical patch localization IGI
Inferred from Genetic Interaction
more info
PubMed 
actin cortical patch localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
actin filament polymerization IDA
Inferred from Direct Assay
more info
 
actin nucleation IDA
Inferred from Direct Assay
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cortical patch IDA
Inferred from Direct Assay
more info
PubMed 
actin cortical patch IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
Names
Las17p
NP_014824.1
  • Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments and a polyproline domain which can nucleate actin filaments independent of Arp2/3; mutants are defective in actin cytoskeleton dependent processes such as: endocytosis, bud site selection and cytokinesis; localizes with the Arp2/3 complex to actin cortical patches; homolog of the Wiskott-Aldrich Syndrome protein (WASP), implicated in severe immunodeficiency

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 

    Range
    675939..677840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183600.1NP_014824.1  Las17p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_014824.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q12446
    Conserved Domains (1) summary
    cd01205
    Location:23131
    Blast Score: 391
    EVH1_WASP-like; WASP family proteins EVH1 domain

Supplemental Content

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