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EFT1 elongation factor 2 [ Saccharomyces cerevisiae S288c ]

Gene ID: 854301, updated on 8-May-2016
Gene symbol
EFT1
Gene description
elongation factor 2
Primary source
SGD:S000005659
Locus tag
YOR133W
Gene type
protein coding
RNA name
elongation factor 2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See EFT1 in Map Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (575098..577626)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative haloacid dehalogenase-like hydrolase Neighboring gene retromer subunit VPS17 Neighboring gene Bag7p Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
rRNA binding IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
maintenance of translational fidelity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translational elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation IEA
Inferred from Electronic Annotation
more info
 
translational elongation IEA
Inferred from Electronic Annotation
more info
 
translational elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with ribosome IDA
Inferred from Direct Assay
more info
PubMed 
Names
elongation factor 2
NP_014776.1
  • Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    575098..577626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183552.1NP_014776.1  elongation factor 2 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_014776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32324
    Conserved Domains (6) summary
    cd01885
    Location:20230
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:558730
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd03700
    Location:378472
    eEF2_snRNP_like_II; EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast ...
    cd04096
    Location:726804
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:1842
    PTZ00416; elongation factor 2; Provisional
    pfam14492
    Location:487557
    EFG_II; Elongation Factor G, domain II