LMO4 LIM domain only 4 [Homo sapiens] - Gene

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Summary

Official Symbol: LMO4provided by HGNC
Official Full Name: LIM domain only 4provided by HGNC
Primary source: HGNC:6644
See related: Ensembl:ENSG00000143013; HPRD:09122; MIM:603129; Vega:OTTHUMG00000010248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]

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Genomic context

Location :: 1p22.3

Sequence :: Chromosome: 1; NC_000001.10 (87794151..87814606)

See LMO4 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LMO4 is over-expressed in highly invasive rhabdomyosarcoma, alveolar cells
Title: Differential expression of invasion promoting genes in childhood rhabdomyosarcoma.
LMO4 expression in squamous cell carcinoma of the anterior tongue
Title: LMO4 expression in squamous cell carcinoma of the anterior tongue.
data indicate that LMO4 has similar cellular effects in normal mammary epithelial cells and breast cancer cells, and also provide direct evidence for the idea that normal development and carcinogenesis share conserved molecular mechanisms
Title: Repression of Lim only protein 4-activated transcription inhibits proliferation and induces apoptosis of normal mammary epithelial cells and breast cancer cells.
LMO4 protects neurons from ischemic brain injury, in part through its requirement as an essential cofactor of PPAR gamma
Title: Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4.
LMO4 is a novel cell cycle regulator with a key role in mediating ErbB2-induced proliferation, a hallmark of ErbB2-positive disease.
Title: LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression.
Lmo4 expression coincides with the timing of the development of the somatosensory barrel field.
Title: Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control.
Results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer.
Title: LIM only 4 is overexpressed in late stage pancreas cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.
In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection
Title: Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma.
These findings reveal a novel complex between BRCA1, LMO4, and CtIP and indicate a role for LMO4 as a repressor of BRCA1 activity in breast tissue.
Title: The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.

Submit: New GeneRIF Correction See all (16)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.

Identification of nine novel Loci associated with white blood cell subtypes in a Japanese population.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006760.1	NP_009227.1	BRCA1	BIND	PubMed	The LIM domain protein LMO4 interacts with BRCA1
NP_006760.1	NP_002885.1	RBBP8	BIND	PubMed	LMO4 interacts with CtIP.
P61968	P38398	BRCA1	HPRD	PubMed
P61968	Q16531	DDB1	HPRD	PubMed
P61968	Q15811	ITSN1	HPRD	PubMed
P61968	O15066	KIF3B	HPRD	PubMed
P61968	P52294	KPNA1	HPRD	PubMed
P61968	Q86U70	LDB1	HPRD	PubMed
P61968	O43679	LDB2	HPRD	PubMed
P61968	Q12866	MERTK	HPRD	PubMed
P61968	Q02575	NHLH1	HPRD	PubMed
P61968	P48739	PITPNB	HPRD	PubMed
P61968	Q99708	RBBP8	HPRD	PubMed
P61968	O94855	SEC24D	HPRD	PubMed
P61968	O15198	SMAD9	HPRD	PubMed
P61968	O43680	TCF21	HPRD	PubMed
P61968	Q9GZM7	TINAGL1	HPRD	PubMed
P61968	Q8WW01	TSEN15	HPRD	PubMed
P61968	TRAF6 inhibitory zinc finger protein	ZNF675	HPRD	PubMed
BioGRID:114113	BioGRID:107140	BRCA1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:114113	BioGRID:107843	CSNK2B	BioGRID	PubMed	Two-hybrid
BioGRID:114113	BioGRID:115777	DEAF1	BioGRID	PubMed	Two-hybrid
BioGRID:114113	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114113	BioGRID:108014	GADD45A	BioGRID	PubMed	Two-hybrid
BioGRID:114113	BioGRID:109187	GSK3B	BioGRID	PubMed	Two-hybrid
BioGRID:114113	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114113	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114113	BioGRID:114384	LDB1	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure
BioGRID:114113	BioGRID:114562	MTA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114113	BioGRID:110868	NFYC	BioGRID	PubMed	Two-hybrid
BioGRID:114113	BioGRID:111362	PLK1	BioGRID	PubMed	Two-hybrid
BioGRID:114113	BioGRID:111867	RBBP8	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114113	BioGRID:118144	RPS6KA6	BioGRID	PubMed	Two-hybrid
BioGRID:114113	BioGRID:114160	TNFSF11	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
enhancer sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
negative regulation of protein complex assembly	IEA Inferred from Electronic Annotation more info
neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
regulation of cell activation	IEA Inferred from Electronic Annotation more info
regulation of cell fate specification	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
spinal cord association neuron differentiation	IEA Inferred from Electronic Annotation more info
spinal cord motor neuron differentiation	IEA Inferred from Electronic Annotation more info
thymus development	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
ventral spinal cord interneuron differentiation	IEA Inferred from Electronic Annotation more info
ventricular septum development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
transcription factor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: LIM domain transcription factor LMO4

Names: LIM domain transcription factor LMO4; LMO-4; breast tumor autoantigen; LIM domain only protein 4

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006769.3 → NP_006760.1 LIM domain transcription factor LMO4

Status: REVIEWED

Source sequence(s)

AC092392, AI962216, AW162477, BU580860, BU619915, U24576

Consensus CDS

CCDS713.1

UniProtKB/Swiss-Prot

P61968

Related

ENSP00000359575, OTTHUMP00000011905, ENST00000370544, OTTHUMT00000028264

Conserved Domains (2) summary

cd09386
Location:23 – 77
Blast Score: 266

LIM1_LMO4; The first LIM domain of LMO4 (LIM domain only protein 4)

cd09387
Location:87 – 141
Blast Score: 276

LIM2_LMO4; The second LIM domain of LMO4 (LIM domain only protein 4)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

87794151..87814606

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

85907757..85928201

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC092392.2 (41819..61635)	None
genomic	CH471097.2	EAW73168.1
		EAW73169.1
mRNA	AI962216.1	None
mRNA	AK292578.1	BAF85267.1
mRNA	AW162477.1	None
mRNA	BC003600.1	AAH03600.1
mRNA	BC017673.1	AAH17673.1
mRNA	BC065818.1	AAH65818.1
mRNA	BU580860.1	None
mRNA	BU619915.1	None
mRNA	U24576.1	AAB51073.1
other-genetic	DQ891447.2	ABM82373.1
other-genetic	DQ894626.2	ABM85552.1